Detailed view for Smp_063040

Basic information

TDR Targets ID: 282744
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 4.8251 | Length (AA): 409 | MW (Da): 45542 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00022   Actin

Gene Ontology

Mouse over links to read term descriptions.
GO:0071564   GO:npBAF complex  

GO:0005515   protein binding  
GO:0043044   ATP-dependent chromatin remodeling  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 408 4b1y (B) 2 374 33.00 0 1 1.28851 -0.06
3 400 5i9e (A) 12 479 32.00 0 1 1.35381 -0.49
4 408 1d4x (A) 4 374 41.00 0 1 1.37792 -0.26
4 409 2p9p (A) 4 413 28.00 0 1 1.24107 -0.11
5 408 5i9e (D) 5 374 42.00 0 1 1.25248 0.07

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128301)

Species Accession Gene Product
Arabidopsis thaliana AT1G18450   actin-related protein 4
Babesia bovis BBOV_I004010   actin, putative
Brugia malayi Bm1_15575   actin-like protein 6B
Candida albicans CaO19.13069   potential NuA4 histone acetyltransferase complex component
Caenorhabditis elegans CELE_ZK616.4   Protein SWSN-6
Cryptosporidium hominis Chro.80259   BRG1/brm-associated factor 53A
Cryptosporidium parvum cgd8_2200   BRG1/brm-associated factor 53A like actin
Dictyostelium discoideum DDB_G0280887   actin related protein 4
Drosophila melanogaster Dmel_CG6546   Brahma associated protein 55kD
Echinococcus granulosus EgrG_001191400   actin 6a
Echinococcus multilocularis EmuJ_001191400   actin 6a
Homo sapiens ENSG00000136518   actin-like 6A
Homo sapiens ENSG00000077080   actin-like 6B
Loa Loa (eye worm) LOAG_02121   actin
Mus musculus ENSMUSG00000029712   actin-like 6B
Mus musculus ENSMUSG00000027671   actin-like 6A
Neospora caninum NCLIV_028320   actin-like family protein ARP4a, putative
Neospora caninum NCLIV_007590   actin-like family protein ARP4a, putative
Oryza sativa 4344621   Os08g0137200
Plasmodium berghei PBANKA_1020600   actin-related protein, putative
Plasmodium falciparum PF3D7_1422800   actin-related protein, putative
Plasmodium knowlesi PKNH_1335200   actin-related protein, putative
Plasmodium vivax PVX_085340   actin, putative
Plasmodium yoelii PY00021   Actin
Saccharomyces cerevisiae YJL081C   Arp4p
Schistosoma japonicum Sjp_0092370   Actin-like protein 6A, putative
Schistosoma mansoni Smp_063040   hypothetical protein
Schistosoma mansoni Smp_184940   hypothetical protein
Schmidtea mediterranea mk4.001411.03   Actin-like protein 6, acl6
Toxoplasma gondii TGME49_258050   actin like protein ALP2a
Toxoplasma gondii TGME49_253040   actin-related protein ARP4A
Theileria parva TP02_0707   actin, putative

Essentiality

Smp_063040 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZK616.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZK616.4 Caenorhabditis elegans larval arrest wormbase
YJL081C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1020600 Plasmodium berghei Essential plasmo
TGME49_253040 Toxoplasma gondii Probably essential sidik
TGME49_258050 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Xenopus laevis beta-actin 375 aa 36.1% 416 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_063040 (Schistosoma mansoni), hypothetical protein
Title for this comment
Comment