Detailed view for Smp_169380

Basic information

TDR Targets ID: 282949
Schistosoma mansoni, protein tyrosine phosphatase
Source Database / ID:  GeneDB

pI: 7.8729 | Length (AA): 1607 | MW (Da): 182008 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00041   Fibronectin type III domain
PF00102   Protein-tyrosine phosphatase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016791   phosphoric monoester hydrolase activity  
GO:0005515   protein binding  
GO:0004725   protein tyrosine phosphatase activity  
GO:0016311   dephosphorylation  
GO:0006470   protein amino acid dephosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
279 369 4wtx (A) 1570 1659 20.00 0 0.5 0.303727 -1.13
723 1103 2b3o (A) 163 516 23.00 0 1 0.283188 0.25
784 1105 2h4v (A) 829 1122 38.00 0 1 0.427073 -0.56
785 1469 2jjd (A) 120 690 32.00 0 1 0.46496 0.52
798 1104 5awx (A) 1735 1994 40.00 0 1 0.476739 -0.35
815 1469 2nlk (A) 874 1411 36.00 0 1 0.487292 0.21
1257 1472 2cjz (A) 309 535 10.00 0.16 0.26 0.295512 -0.63
1322 1466 3cm3 (A) 1019 1169 11.00 0 0.25 0.19733 -0.72

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_206393)

Species Accession Gene Product
Echinococcus granulosus EgrG_000214300   receptor type tyrosine protein phosphatase zeta
Echinococcus multilocularis EmuJ_000214300   receptor type tyrosine protein phosphatase zeta
Schistosoma japonicum Sjp_0045390   Receptor-type tyrosine-protein phosphatase kappa precursor, putative
Schistosoma japonicum Sjp_0115440   hypothetical protein
Schistosoma japonicum Sjp_0120120   hypothetical protein
Schistosoma japonicum Sjp_0088720   IPR003961,Fibronectin, type III;IPR000242,Tyrosine specific protein phosphatase;IPR008957,Fibronectin, type III-like fold,domain
Schistosoma mansoni Smp_169380   protein tyrosine phosphatase
Schmidtea mediterranea mk4.000920.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0275 0.301 0.301
0.0048 0.4176 0.4176
0.0351 0.6072 0
0.0165 0.3513 0.4019
0.0083 1 0.5
0.0116 0.6967 0.6967
0.0251 0.7407 0.7375
0.0461 0.2819 0.2813
0.0403 0.706 0.706
0.0446 0.3014 0.4674
0.022 0.257 0.6919
0.0084 0.6788 1
0.0129 0.3276 0.3276
0.0446 0.3014 0.4674
0.0156 0.6042 0.6042
0.0471 0.341 0.3405
0.0089 0.442 0.6887
0.0216 0.3372 0.387
0.0089 0.4623 0.4623
0.008 0.4641 0
0.0167 0.3197 0.351
0.0258 0.3891 0.4414
0.0178 0.5983 0.5983
0.0153 0.3082 0.3318
0.0461 0.2819 0.2813
0.0165 0.3513 0.4019
0.012 0.7362 0.7362
0.012 0.7362 0.7362
0.0343 0.706 0.706
0.0343 0.706 0.706
0.0344 0.6972 0.6972
0.0448 0.7636 0.7636
0.0011 1 1
0.037 0.706 0.706
0.0334 0.4633 0.4633
0.0251 0.7407 0.7375
0.0272 0.706 0.706
0.0178 0.5983 0.5983
0.0275 0.301 0.301
0.0338 0.7566 0.752
0.0261 0.2557 0.2988
0.0446 0.3014 0.4674
0.0378 0.586 0.586
0.0115 0.2557 0.2988
0.0009 0.5 0.5
0.0075 0.4317 0.4447
0.0261 0.3873 0.4396
0.0255 0.2557 0.2988
0.0488 0.3798 0.3794
0.0374 0.7576 0.7576
0.0156 0.6042 0.6042
0.0313 0.5953 0.7027
0.0446 0.3014 0.4674
0.043 0.5151 0.5151
0.0461 0.2819 0.2813
0.0085 0.3268 0.3432
0.0255 0.706 0.706
0.0334 0.4633 0.4633
0.0048 0.432 0.432
0.0184 0.706 0.706
0.0275 0.301 0.301
0.0111 0.334 1
0.0016 1 0.5
0.0223 0.4639 0.4639
0.0132 0.2972 0.7394
0.0241 0.3986 0.4512
0.0255 0.706 0.706
0.0142 0.2992 0.3276
0.0461 0.2819 0.2813
0.0471 0.341 0.3405
0.0374 0.7576 0.7576
0.0155 0.3568 0.706
0.0241 0.3619 0.413
0.0223 0.4639 0.4639
0.0084 0.6788 1
0.0275 0.301 0.301
0.0312 0.5397 0
0.0271 0.3613 0.7611
0.0164 0.7647 0.7647
0.0011 1 1
0.0378 0.586 0.586
0.0039 0.3299 0.3527
0.0336 0.3462 0.4786
0.0446 0.3014 0.4674
0.022 0.257 0.6919
0.0114 0.6153 0.3459
0.02 0.7068 0.706
0.0011 1 1
0.0446 0.3014 0.4674
0.0104 0.8804 1
0.0446 0.3014 0.4674
0.0266 0.2855 0.5677
0.017 0.2614 0.6652
0.0414 0.6115 0.6115
0.0089 0.442 0.6887
0.0446 0.3014 0.4674
0.0216 0.706 0.706
0.0475 0.706 0.706
0.0167 0.3197 0.351
0.0034 0.2581 0.2581
0.0414 0.6115 0.6115
0.0275 0.301 0.301

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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