Detailed view for Smp_008320

Basic information

TDR Targets ID: 283157
Schistosoma mansoni, pap-inositol-14-phosphatase

Source Database / ID:  GeneDB

pI: 5.0292 | Length (AA): 325 | MW (Da): 35400 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00459   Inositol monophosphatase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0004437   inositol or phosphatidylinositol phosphatase activity  
GO:0046854   phosphoinositide phosphorylation  

Metabolic Pathways

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 321 2wef (A) 6 306 42.00 0 1 1.53426 -1.12
5 299 1jp4 (A) 7 286 47.00 0 1 1.41889 -0.81
7 324 2p3n (A) 1 256 24.00 0 1 1.00936 0.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131693)

Species Accession Gene Product
Brugia malayi Bm1_41990   Inositol monophosphatase family protein
Caenorhabditis elegans CELE_ZK430.2   Protein TAG-231
Dictyostelium discoideum DDB_G0275663   3',5'-bisphosphate nucleotidase 1
Drosophila melanogaster Dmel_CG7789   CG7789 gene product from transcript CG7789-RA
Echinococcus granulosus EgrG_000670100   3'2'5' bisphosphate nucleotidase 1
Entamoeba histolytica EHI_179820   3(2),5-bisphosphate nucleotidase, putative
Echinococcus multilocularis EmuJ_000670100   3'(2'),5' bisphosphate nucleotidase 1
Homo sapiens ENSG00000162813   3'(2'), 5'-bisphosphate nucleotidase 1
Loa Loa (eye worm) LOAG_05255   hypothetical protein
Mus musculus ENSMUSG00000026617   bisphosphate 3'-nucleotidase 1
Schistosoma japonicum Sjp_0204150   ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative
Schistosoma mansoni Smp_008320   pap-inositol-14-phosphatase
Schmidtea mediterranea mk4.013688.00   3'(2'),5'-bisphosphate nucleotidase 1
Schmidtea mediterranea mk4.021372.00   3'(2'),5'-bisphosphate nucleotidase 1
Schmidtea mediterranea mk4.024877.00   3'(2'),5'-bisphosphate nucleotidase 1
Schmidtea mediterranea mk4.041504.00   3'(2'),5'-bisphosphate nucleotidase 1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Inositol monophosphatase 1 277 aa 22.9% 279 aa Compounds References
Bos taurus Inositol-1(or 4)-monophosphatase 1 277 aa 23.3% 287 aa Compounds References

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_008320 (Schistosoma mansoni), pap-inositol-14-phosphatase
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