Detailed view for Smp_173790
Basic information
Schistosoma mansoni, o-acyltransferase (membrane bound) domain containing protein
Source Database / ID: GeneDB
pI: 9.776 |
Length (AA): 523 |
MW (Da): 60759 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 10
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
Metabolic Pathways
Structural information
Modbase 3D models:
PDB Structures:
Expression
Orthologs
Ortholog group members (OG5_127920)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT1G12640 | lysophosphatidylcholine acyltransferase 1 |
| Arabidopsis thaliana | AT1G63050 | lysophosphatidylcholine acyltransferase |
| Brugia malayi | Bm1_34850 | MBOAT family protein |
| Brugia malayi | Bm1_34855 | MBOAT family protein |
| Candida albicans | CaO19.1881 | similar to S. cerevisiae YOR175C |
| Candida albicans | CaO19.9437 | similar to S. cerevisiae YOR175C |
| Caenorhabditis elegans | CELE_C08F8.4 | Protein MBOA-4, isoform C |
| Caenorhabditis elegans | CELE_C54G7.2 | Protein MBOA-3 |
| Caenorhabditis elegans | CELE_ZK550.1 | Protein MBOA-5 |
| Dictyostelium discoideum | DDB_G0278541 | membrane bound O-acyl transferase family protein |
| Drosophila melanogaster | Dmel_CG18445 | oysgedart |
| Echinococcus granulosus | EgrG_000975700 | o acyltransferase membrane bound domain |
| Echinococcus granulosus | EgrG_000296000 | o acyltransferase membrane bound domain |
| Echinococcus granulosus | EgrG_000724000 | o acyltransferase membrane bound domain |
| Entamoeba histolytica | EHI_086180 | membrane-bound O-acyltransferase (MBOAT ) family protein |
| Entamoeba histolytica | EHI_103460 | membrane-bound O-acyltransferase (MBOAT ) family protein |
| Entamoeba histolytica | EHI_162540 | vacuolar protein sorting 26 |
| Echinococcus multilocularis | EmuJ_000296000 | o acyltransferase (membrane bound) domain |
| Echinococcus multilocularis | EmuJ_000975700 | o acyltransferase (membrane bound) domain |
| Echinococcus multilocularis | EmuJ_000724000 | o acyltransferase (membrane bound) domain |
| Homo sapiens | 129642 | membrane bound O-acyltransferase domain containing 2 |
| Homo sapiens | 154141 | membrane bound O-acyltransferase domain containing 1 |
| Loa Loa (eye worm) | LOAG_15529 | membrane bound O-acyltransferase domain containing 1 |
| Loa Loa (eye worm) | LOAG_15679 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_11398 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_00577 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_11396 | hypothetical protein |
| Mus musculus | ENSMUSG00000038732 | membrane bound O-acyltransferase domain containing 1 |
| Mus musculus | ENSMUSG00000020646 | membrane bound O-acyltransferase domain containing 2 |
| Oryza sativa | 4330302 | Os02g0676000 |
| Onchocerca volvulus | OVOC2409 |
|
| Saccharomyces cerevisiae | YOR175C | Ale1p |
| Schistosoma japonicum | Sjp_0108640 | Membrane-bound O-acyltransferase domain-containing protein 2, putative |
| Schistosoma japonicum | Sjp_0009460 | Membrane-bound O-acyltransferase domain-containing protein 2, putative |
| Schistosoma japonicum | Sjp_0306240 | Membrane-bound O-acyltransferase domain-containing protein 1, putative |
| Schistosoma mansoni | Smp_173790 | o-acyltransferase (membrane bound) domain containing protein |
| Schistosoma mansoni | Smp_079860.2 | o-acyltransferase (membrane bound) domain containing protein |
| Schistosoma mansoni | Smp_079860.1 | o-acyltransferase (membrane bound) domain containing protein |
| Schmidtea mediterranea | mk4.011352.01 | MBOAT2 |
| Schmidtea mediterranea | mk4.000680.01 | |
| Schmidtea mediterranea | mk4.004156.01 | |
| Schmidtea mediterranea | mk4.007072.01 | |
| Schmidtea mediterranea | mk4.000012.05 | |
| Schmidtea mediterranea | mk4.000680.00 | |
| Schmidtea mediterranea | mk4.011352.00 | |
| Trichomonas vaginalis | TVAG_029540 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_115820 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_446720 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_029550 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_025150 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_313140 | porcupine, putative |
| Trichomonas vaginalis | TVAG_110690 | transmembrane protein nessy, putative |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
By sequence similarity to non orthologous druggable targets
Obtained from network model
Assayability
Assay information
Reagent availability
Bibliographic References