Detailed view for Smp_058730

Basic information

TDR Targets ID: 283334
Schistosoma mansoni, tubby tubby-like
Source Database / ID:  GeneDB

pI: 7.5768 | Length (AA): 510 | MW (Da): 57837 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01167   Tub family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
128 217 5lx8 (A) 98 187 28.00 0.39 0.34 0.528771 -0.88
256 510 1c8z (A) 248 505 62.00 0 1 1.2732 -0.84

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128355)

Species Accession Gene Product
Arabidopsis thaliana AT1G76900   tubby-like F-box protein 1
Arabidopsis thaliana AT3G06380   tubby-like F-box protein 9
Arabidopsis thaliana AT5G18680   Tubby-like F-box protein 11
Arabidopsis thaliana AT2G47900   Tubby-like F-box protein 3
Brugia malayi Bm1_15255   hypothetical protein
Caenorhabditis elegans CELE_F10B5.4   Protein TUB-1
Drosophila melanogaster Dmel_CG9398   king tubby
Echinococcus granulosus EgrG_000698200   tubby protein
Echinococcus multilocularis EmuJ_000698200   tubby protein
Homo sapiens ENSG00000166402   tubby bipartite transcription factor
Homo sapiens ENSG00000078246   tubby like protein 3
Loa Loa (eye worm) LOAG_13477   hypothetical protein
Loa Loa (eye worm) LOAG_14384   hypothetical protein
Mus musculus ENSMUSG00000001521   tubby-like protein 3
Mus musculus ENSMUSG00000031028   tubby candidate gene
Oryza sativa 4337480   Os04g0687900
Oryza sativa 4344218   Os07g0667000
Oryza sativa 4338909   Os05g0437900
Oryza sativa 4351582   Os12g0163400
Oryza sativa 4344429   Os08g0103300
Oryza sativa 4332845   Os03g0351400
Oryza sativa 4325075   Os01g0866800
Onchocerca volvulus OVOC11413   Tubby protein homolog
Schistosoma japonicum Sjp_0101840   Tubby protein homolog, putative
Schistosoma japonicum Sjp_0092170   Tubby protein homolog, putative
Schistosoma mansoni Smp_058730   tubby tubby-like
Schmidtea mediterranea mk4.009187.00   Tubby protein homolog 1
Schmidtea mediterranea mk4.001593.00   Tubby protein homolog 1
Schmidtea mediterranea mk4.010998.01  
Schmidtea mediterranea mk4.010998.00   Tubby protein homolog 1
Schmidtea mediterranea mk4.034608.00   Tubby protein homolog 1
Trichomonas vaginalis TVAG_116270   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_058730 (Schistosoma mansoni), tubby tubby-like
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