Detailed view for Smp_165420

Basic information

TDR Targets ID: 283418
Schistosoma mansoni, zinc finger protein
Source Database / ID:  GeneDB

pI: 7.4483 | Length (AA): 4034 | MW (Da): 454773 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00096   Zinc finger, C2H2 type

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0005634   nucleus  
GO:0005622   intracellular  
GO:0008270   zinc ion binding  
GO:0005488   binding  
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
91 267 5t0u (A) 293 462 29.00 0 1 0.228477 1.02
127 229 3w5k (B) 153 255 56.00 0 1 0.413633 0.47
178 207 2yu5 (A) 9 38 43.00 0.97 0.82 0.647437 -1.43
178 208 2ytt (A) 9 39 48.00 0.09 1 0.733685 -1.61
335 474 1b3u (A) 243 380 17.00 0.23 0.85 0.293305 -0.57
336 963 1b3u (A) 12 586 15.00 0 0.9 0.0627767 0.32
1341 2286 3gb8 (A) 71 1032 11.00 0 0.96 0.116607 0.47
1391 2442 1u6g (C) 104 1144 11.00 0 0.89 0.0638833 0.81
1722 2538 1qbk (B) 9 812 11.00 0 0.2 -0.0823715 1.18
1742 2658 1z3h (B) 18 958 12.00 0 1 0.0654178 0.67
1959 2127 2db0 (A) 23 197 25.00 0.72 0.88 0.251894 -0.17
3665 3728 1vcr (A) 56 183 34.00 0.71 0.07 0.113465 1.66

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_168248)

Species Accession Gene Product
Echinococcus granulosus EgrG_000942100   zinc finger protein
Echinococcus granulosus EgrG_001138700   huntingtin
Echinococcus multilocularis EmuJ_000942300   zinc finger protein
Echinococcus multilocularis EmuJ_001138700   huntingtin
Echinococcus multilocularis EmuJ_000942100   zinc finger protein
Schistosoma japonicum Sjp_0022920   ko:K02684 DNA primase small subunit, putative
Schistosoma japonicum Sjp_0054950   ko:K04533 huntingtin, putative
Schistosoma mansoni Smp_165420   zinc finger protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_165420 (Schistosoma mansoni), zinc finger protein
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