pI: 7.0088 |
Length (AA): 923 |
MW (Da): 104349 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 12 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
248 | 562 | 4btf (A) | 149 | 453 | 22.00 | 0.000000081 | 1 | 0.480778 | 0.07 |
324 | 622 | 5ckw (B) | 97 | 402 | 15.00 | 0 | 1 | 0.311144 | 0.47 |
328 | 565 | 5jt2 (D) | 480 | 717 | 34.00 | 0.0000000045 | 0.92 | 0.471355 | 0.15 |
341 | 565 | 5uab (A) | 1121 | 1340 | 27.00 | 0 | 1 | 0.59997 | -0.97 |
342 | 601 | 4uy9 (A) | 182 | 446 | 27.00 | 0.000000000014 | 1 | 0.51219 | -0.24 |
348 | 497 | 1v0o (B) | 51 | 195 | 26.00 | 0.0088 | 0.77 | 0.445014 | 0.01 |
573 | 622 | 3hls (A) | 354 | 406 | 38.00 | 0.28 | 0.2 | 0.357671 | 0.23 |
595 | 815 | 5o5l (A) | 207 | 424 | 42.00 | 0 | 1 | 0.756637 | -0.55 |
626 | 815 | 4p2f (A) | 240 | 424 | 38.00 | 0 | 1 | 0.702051 | -0.69 |
628 | 808 | 4ni2 (A) | 472 | 649 | 44.00 | 0 | 1 | 0.7423 | -0.49 |
630 | 812 | 3et6 (A) | 470 | 650 | 47.00 | 0 | 1 | 0.732467 | -0.41 |
630 | 817 | 2wz1 (A) | 414 | 608 | 43.00 | 0 | 1 | 0.688884 | -0.52 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_131357)
Species | Accession | Gene Product |
---|---|---|
Drosophila melanogaster | Dmel_CG34357 | CG34357 gene product from transcript CG34357-RD |
Echinococcus granulosus | EgrG_000682150 | 3'partial|retinal guanylyl cyclase 2 |
Echinococcus granulosus | EgrG_000406000 | retinal guanylyl cyclase 2 |
Echinococcus granulosus | EgrG_000504700 | retinal guanylyl cyclase 2 |
Echinococcus granulosus | EgrG_000554500 | retinal guanylyl cyclase 2 |
Echinococcus multilocularis | EmuJ_000406000 | retinal guanylyl cyclase 2 |
Echinococcus multilocularis | EmuJ_000504700 | retinal guanylyl cyclase 2 |
Echinococcus multilocularis | EmuJ_000554500 | retinal guanylyl cyclase 2 |
Homo sapiens | ENSG00000101890 | guanylate cyclase 2F, retinal |
Homo sapiens | ENSG00000132518 | guanylate cyclase 2D, membrane (retina-specific) |
Mus musculus | ENSMUSG00000020890 | guanylate cyclase 2e |
Mus musculus | ENSMUSG00000074003 | guanylate cyclase 2d |
Mus musculus | ENSMUSG00000042282 | guanylate cyclase 2f |
Schistosoma japonicum | Sjp_0091130 | IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing |
Schistosoma japonicum | Sjp_0091120 | Retinal guanylyl cyclase 2 precursor, putative |
Schistosoma japonicum | Sjp_0108870 | Retinal guanylyl cyclase 1 precursor, putative |
Schistosoma japonicum | Sjp_0114400 | hypothetical protein |
Schistosoma japonicum | Sjp_0039810 | hypothetical protein |
Schistosoma mansoni | Smp_125450 | protein tyrosine kinase |
Schmidtea mediterranea | mk4.010519.00 | |
Schmidtea mediterranea | mk4.008307.00 | Guanylate cyclase |
Schmidtea mediterranea | mk4.010183.00 | Guanylate cyclase |
Schmidtea mediterranea | mk4.022429.00 | |
Schmidtea mediterranea | mk4.022429.01 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Jak1 protein | 210 aa | 25.0% | 208 aa | Compounds | References |