Detailed view for Smp_127490

Basic information

TDR Targets ID: 283484
Schistosoma mansoni, blooms syndrome DNA helicase

Source Database / ID:  GeneDB

pI: 8.5018 | Length (AA): 901 | MW (Da): 100446 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00271   Helicase conserved C-terminal domain
PF00570   HRDC domain
PF09382   RQC domain
PF16124   RecQ zinc-binding

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0005524   ATP binding  
GO:0004386   helicase activity  
GO:0003824   catalytic activity  
GO:0003676   nucleic acid binding  
GO:0000166   nucleotide binding  
GO:0043140   ATP-dependent 3'-5' DNA helicase activity  
GO:0044237   cellular metabolic process  
GO:0006281   DNA repair  
GO:0006260   DNA replication  

Metabolic Pathways

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
33 363 4k6j (A) 691 1056 11.00 0 0.11 0.41387 -0.44
176 690 2v1x (A) 104 591 20.00 0 1 0.728087 0.4
375 427 4o3m (A) 649 701 55.00 0 1 0.657324 0.1
692 822 2dgz (A) 1134 1245 19.00 0 0.37 0.193894 -0.33
717 789 1wud (A) 534 603 24.00 0 1 0.471521 -1.35
719 789 2rhf (A) 755 822 25.00 0 0.95 0.442301 -1.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_189722)

Species Accession Gene Product
Oryza sativa 4335888   Os04g0433800
Schistosoma japonicum Sjp_0132260   IPR002121,HRDC,domain-containing
Schistosoma japonicum Sjp_0006850   Bloom syndrome protein homolog, putative
Schistosoma japonicum Sjp_0132240   Bloom syndrome protein homolog, putative
Schistosoma mansoni Smp_127490   blooms syndrome DNA helicase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0019 0.2617 0.2617
0.0361 0.4032 0.8676
0.002 0.7335 1
0.002 0.5558 0.4487
0.07141 0.262215 0.262215
0.002 0.5498 0.5498
0.0391 0.4191 0.5793
0.07141 0.262215 0.262215
0.016 0.3746 0.3746
0.0027 0.2641 0.2641
0.002 0.5558 0.4487
0.0017 0.375 0.375
0.00749823 0.275642 1
0.0019 0.2617 0.2617
0.0032 0.2641 0.2641
0.0027 0.2641 0.2641
0.0379 0.4343 0.5114
0.0138 0.336 0.7864
0.002 0.5558 0.4487
0.0123 0.4639 0.8034
0.006 0.2673 1
0.0012 0.3024 0.3024
0.07141 0.262215 0.262215
0.002 0.2725 0.2996
0.0174227 0.365654 0.965959
0.002 0.5498 0.5498
0.001 0.3192 0.3192
0.0114 0.2798 0.3974
0.0229 0.3708 1
0.0281 0.2512 0.2505
0.0007 0.3695 0.3695
0.001 0.3885 0.3885
0.0379 0.4343 0.5114

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_127490 (Schistosoma mansoni), blooms syndrome DNA helicase
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