Detailed view for Smp_132860

Basic information

TDR Targets ID: 283558
Schistosoma mansoni, cript-related
Source Database / ID:  GeneDB

pI: 8.7625 | Length (AA): 427 | MW (Da): 48344 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03372   Endonuclease/Exonuclease/phosphatase family
PF10235   Microtubule-associated protein CRIPT

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 329 4gew (A) 53 360 30.00 0 1 1.09199 -0.5
47 326 5ht2 (A) 115 363 40.00 0 1 0.993838 -0.17
55 326 5j3p (A) 113 355 40.00 0 1 1.0421 -0.64
56 329 4f1h (A) 123 367 32.00 0 1 0.996186 -0.63
56 382 4ruw (A) 53 366 17.00 0 0.4 0.748308 -0.11
228 381 6n3h (A) 495 640 28.00 0.54 0.18 0.162756 1.07

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130456)

Species Accession Gene Product
Arabidopsis thaliana AT1G61780   postsynaptic-related protein
Babesia bovis BBOV_II002970   conserved hypothetical protein
Brugia malayi Bm1_41840   CRIPT protein
Caenorhabditis elegans CELE_C36B1.14   Protein C36B1.14
Drosophila melanogaster Dmel_CG4537   CG4537 gene product from transcript CG4537-RB
Echinococcus granulosus EgrG_000602600   Cysteine rich PDZ binding protein
Echinococcus multilocularis EmuJ_000602600   Cysteine rich PDZ binding protein
Homo sapiens 9419   cysteine-rich PDZ-binding protein
Loa Loa (eye worm) LOAG_02127   CRIPT protein
Mus musculus ENSMUSG00000024146   cysteine-rich PDZ-binding protein
Neospora caninum NCLIV_066200   hypothetical protein
Oryza sativa 4344850   Os08g0190800
Plasmodium berghei PBANKA_0903700   cysteine-rich PDZ-binding protein, putative
Plasmodium falciparum PF3D7_1145300   cysteine-rich PDZ-binding protein, putative
Plasmodium knowlesi PKNH_0943200   cysteine-rich PDZ-binding protein, putative
Plasmodium vivax PVX_092870   cysteine-rich PDZ-binding protein, putative
Plasmodium yoelii PY00715   hypothetical protein
Schistosoma japonicum Sjp_0055120   TRAF and TNF receptor-associated protein, putative
Schistosoma japonicum Sjp_0308250   Cysteine-rich PDZ-binding protein, putative
Schistosoma mansoni Smp_132860   cript-related
Schmidtea mediterranea mk4.002726.00   Cript-related
Toxoplasma gondii TGME49_250350   CRIPT, putative

Essentiality

Smp_132860 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C36B1.14 Caenorhabditis elegans embryonic lethal wormbase
CELE_C36B1.14 Caenorhabditis elegans larval arrest wormbase
CELE_C36B1.14 Caenorhabditis elegans slow growth wormbase
CELE_C36B1.14 Caenorhabditis elegans sterile wormbase
PBANKA_0903700 Plasmodium berghei Dispensable plasmo
TGME49_250350 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Danio rerio Tyrosyl-DNA phosphodiesterase 2 369 aa 30.8% 315 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_132860 (Schistosoma mansoni), cript-related
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