Detailed view for LmjF.01.0470

Basic information

TDR Targets ID: 28367
Leishmania major, fatty acyl CoA syntetase 1, putative

Source Database / ID:  TriTrypDB  GeneDB

pI: 6.094 | Length (AA): 696 | MW (Da): 77450 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00501   AMP-binding enzyme

Gene Ontology

Mouse over links to read term descriptions.
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
20 691 1pg4 (A) 10 634 17.00 0 1 1.01 0.21
90 625 1v25 (A) 19 537 22.00 0 1 0.99 -0.47
29 684 5jrh (A) 21 617 17.00 0 1 0.954929 0.59
102 199 4lgc (A) 41 140 14.00 0.0000042 0.53 0.400205 -0.75
121 581 1v25 (B) 49 466 28.00 0 1 0.729356 0.53
503 554 3cw9 (A) 351 401 47.00 0.043 0.47 0.437713 0.84

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_126601)

Species Accession Gene Product
Arabidopsis thaliana AT4G11030   long-chain acyl-CoA synthetase
Arabidopsis thaliana AT5G27600   long-chain acyl-CoA synthetase 7
Arabidopsis thaliana AT2G04350   long chain acyl-CoA synthetase 8
Arabidopsis thaliana AT4G23850   long chain acyl-CoA synthetase 4
Arabidopsis thaliana AT3G05970   long-chain acyl-CoA synthetase 6
Arabidopsis thaliana AT1G77590   long chain acyl-CoA synthetase 9
Arabidopsis thaliana AT1G49430   long-chain acyl-CoA synthetase 2
Arabidopsis thaliana AT1G64400   long-chain acyl-CoA synthetase
Arabidopsis thaliana AT2G47240   long chain acyl-CoA synthetase 1
Babesia bovis BBOV_III002500   fatty acyl-CoA synthetase family protein
Babesia bovis BBOV_IV000960   fatty acyl-CoA synthetase 3
Brugia malayi Bm1_23980   AMP-binding enzyme family protein
Brugia malayi Bm1_47395   AMP-binding enzyme family protein
Candida albicans CaO19_7156   hypothetical protein
Candida albicans CaO19.7379   one of four genes similar to S. cerevisiae fatty acyl-CoA synthetase FAA2 (YER015W)
Candida albicans CaO19.7904   one of four genes similar to S. cerevisiae fatty acyl-CoA synthetase FAA2 (YER015W)
Candida albicans CaO19.11595   one of four genes similar to S. cerevisiae fatty acyl-CoA synthetase FAA2 (YER015W)
Candida albicans CaO19.4114   one of four genes similar to S. cerevisiae fatty acyl-CoA synthetase FAA2 (YER015W)
Candida albicans CaO19.272   one of four genes similar to S. cerevisiae fatty acyl-CoA synthetase FAA2 (YER015W)
Candida albicans CaO19.7156   one of four genes similar to S. cerevisiae fatty acyl-CoA synthetase FAA2 (YER015W)
Candida albicans CaO19.7592   similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase
Caenorhabditis elegans CELE_F37C12.7   Protein ACS-4
Caenorhabditis elegans CELE_Y76A2B.3   Protein ACS-5
Caenorhabditis elegans CELE_C46F4.2   Protein ACS-17
Caenorhabditis elegans CELE_Y65B4BL.5   Protein ACS-13
Cryptosporidium hominis Chro.30084   acyl-CoA synthetase
Cryptosporidium hominis Chro.40386   long chain fatty acid synthetase
Cryptosporidium hominis Chro.50052   long-chain fatty acid CoA ligase
Cryptosporidium parvum cgd5_3200   putative acyl-CoA synthetase
Cryptosporidium parvum cgd4_3400   putative long chain fatty acyl CoA synthetase having a signal peptide
Cryptosporidium parvum cgd3_640   acyl-CoA synthetase
Dictyostelium discoideum DDB_G0269474   fatty acyl-CoA synthetase
Dictyostelium discoideum DDB_G0269242   fatty acyl-CoA synthetase
Drosophila melanogaster Dmel_CG8732   Acyl-CoA synthetase long-chain
Drosophila melanogaster Dmel_CG3961   CG3961 gene product from transcript CG3961-RC
Echinococcus granulosus EgrG_000433400   vacuolar protein sorting associated protein 53
Echinococcus granulosus EgrG_000457800   long chain fatty acid coenzyme A ligase 1
Echinococcus granulosus EgrG_000078800   long chain fatty acid coenzyme A ligase 5
Echinococcus granulosus EgrG_000376500   long chain fatty acid coenzyme A ligase 4
Echinococcus granulosus EgrG_000708900   long chain fatty acid coenzyme A ligase 1
Echinococcus granulosus EgrG_000445600   long chain fatty acid coenzyme A ligase 5
Entamoeba histolytica EHI_153060   acyl-CoA synthetase, putative
Entamoeba histolytica EHI_132030   long-chain-fatty-acid--CoA ligase, putative
Entamoeba histolytica EHI_127830   long-chain-fatty-acid--CoA ligase, putative
Entamoeba histolytica EHI_147010   long-chain-fatty-acid--CoA ligase, putative
Entamoeba histolytica EHI_153720   long-chain-fatty-acid--CoA ligase, putative
Entamoeba histolytica EHI_156320   long-chain-fatty-acid--CoA ligase, putative
Entamoeba histolytica EHI_025090   long-chain-fatty-acid--CoA ligase, putative
Entamoeba histolytica EHI_188590   long-chain-fatty-acid--CoA ligase, putative
Entamoeba histolytica EHI_079300   long-chain-fatty-acid--CoA ligase, putative
Entamoeba histolytica EHI_148340   long-chain-fatty-acid--CoA ligase, putative
Echinococcus multilocularis EmuJ_000445600   long chain fatty acid coenzyme A ligase 5
Echinococcus multilocularis EmuJ_000078800   long chain fatty acid coenzyme A ligase 5
Echinococcus multilocularis EmuJ_000457800   long chain fatty acid coenzyme A ligase 1
Echinococcus multilocularis EmuJ_000376500   long chain fatty acid coenzyme A ligase 4
Echinococcus multilocularis EmuJ_000433400   vacuolar protein sorting associated protein 53
Echinococcus multilocularis EmuJ_000708900   long chain fatty acid coenzyme A ligase 1
Giardia lamblia GL50803_30476   Long chain fatty acid CoA ligase 4
Giardia lamblia GL50803_9062   Long chain fatty acid CoA ligase 5
Homo sapiens ENSG00000068366   acyl-CoA synthetase long-chain family member 4
Homo sapiens ENSG00000164398   acyl-CoA synthetase long-chain family member 6
Homo sapiens ENSG00000197142   acyl-CoA synthetase long-chain family member 5
Homo sapiens ENSG00000151726   acyl-CoA synthetase long-chain family member 1
Homo sapiens 2181   acyl-CoA synthetase long-chain family member 3
Leishmania braziliensis LbrM.03.0240   long chain fatty Acyl CoA synthetase, putative
Leishmania braziliensis LbrM.01.0550   long-chain-fatty-acid-CoA ligase, putative
Leishmania braziliensis LbrM.01.0520   fatty acyl CoA syntetase 1, putative
Leishmania braziliensis LbrM.01.0540   long-chain-fatty-acid-CoA ligase, putative
Leishmania donovani LdBPK_030220.1   long chain fatty Acyl CoA synthetase, putative
Leishmania donovani LdBPK_010510.1   long chain fatty acid CoA ligase, putative
Leishmania donovani LdBPK_010540.1   long chain fatty acid CoA ligase, putative
Leishmania donovani LdBPK_010520.1   fatty acyl CoA synthetase 2, putative
Leishmania donovani LdBPK_010490.1   fatty acyl CoA syntetase 1, putative
Leishmania infantum LinJ.03.0220   long chain fatty Acyl CoA synthetase, putative
Leishmania infantum LinJ.01.0540   long-chain-fatty-acid-CoA ligase, putative
Leishmania infantum LinJ.01.0490   fatty acyl CoA syntetase 1, putative
Leishmania infantum LinJ.01.0510   long-chain-fatty-acid-CoA ligase, putative
Leishmania infantum LinJ.01.0520   fatty acyl CoA synthetase 2, putative
Leishmania major LmjF.01.0520   long-chain-fatty-acid-CoA ligase, putative
Leishmania major LmjF.03.0230   long chain fatty Acyl CoA synthetase, putative
Leishmania major LmjF.01.0500   fatty acyl CoA synthetase 2, putative
Leishmania major LmjF.01.0490   long-chain-fatty-acid-CoA ligase, putative
Leishmania major LmjF.01.0470   fatty acyl CoA syntetase 1, putative
Leishmania mexicana LmxM.01.0470   fatty acyl CoA syntetase 1, putative
Leishmania mexicana LmxM.01.0490   long-chain-fatty-acid-CoA ligase, putative
Leishmania mexicana LmxM.01.0500   fatty acyl CoA synthetase 2, putative
Leishmania mexicana LmxM.03.0230   long chain fatty Acyl CoA synthetase, putative
Leishmania mexicana LmxM.01.0520   long-chain-fatty-acid-CoA ligase, putative
Loa Loa (eye worm) LOAG_03841   hypothetical protein
Loa Loa (eye worm) LOAG_10099   AMP-binding enzyme family protein
Loa Loa (eye worm) LOAG_03400   hypothetical protein
Loa Loa (eye worm) LOAG_16131   hypothetical protein
Loa Loa (eye worm) LOAG_15918   acyl-CoA synthetase long-chain family member 6
Mycobacterium leprae ML0484c   Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Mus musculus ENSMUSG00000020333   acyl-CoA synthetase long-chain family member 6
Mus musculus ENSMUSG00000018796   acyl-CoA synthetase long-chain family member 1
Mus musculus ENSMUSG00000031278   acyl-CoA synthetase long-chain family member 4
Mus musculus ENSMUSG00000032883   acyl-CoA synthetase long-chain family member 3
Mus musculus ENSMUSG00000024981   acyl-CoA synthetase long-chain family member 5
Mycobacterium tuberculosis Rv2590   Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Mycobacterium ulcerans MUL_3274   long-chain-fatty-acid-CoA ligase, FadD11
Mycobacterium ulcerans MUL_4923   acyl carrier protein
Mycobacterium ulcerans MUL_1722   fatty-acid-CoA ligase FadD9
Neospora caninum NCLIV_063970   long chain acyl-CoA synthetase, putative
Neospora caninum NCLIV_018500   Fatty acyl-CoA synthetase 2, related
Oryza sativa 4340187   Os06g0158000
Oryza sativa 4349764   Os11g0147000
Oryza sativa 4324393   Os01g0681200
Oryza sativa 4350728   Os11g0558300
Oryza sativa 4351483   Os12g0143900
Oryza sativa 4349889   Os11g0169800
Oryza sativa 4337714   Os05g0132100
Oryza sativa 4324180   Os01g0655800
Oryza sativa 4338395   Os05g0317200
Oryza sativa 4351610   Os12g0168700
Plasmodium berghei PBANKA_1239900   acyl-CoA synthetase, putative
Plasmodium falciparum PF3D7_0525100   acyl-CoA synthetase
Plasmodium knowlesi PKNH_1007700   acyl-CoA synthetase, putative
Plasmodium vivax PVX_079990   long-chain fatty acid CoA ligase, putative
Plasmodium yoelii PY01239   putative acyl-CoA synthetase
Saccharomyces cerevisiae YOR317W   long-chain fatty acid-CoA ligase FAA1
Saccharomyces cerevisiae YER015W   medium-chain fatty acid-CoA ligase FAA2
Saccharomyces cerevisiae YMR246W   long-chain fatty acid-CoA ligase FAA4
Saccharomyces cerevisiae YIL009W   long-chain fatty acid-CoA ligase FAA3
Schistosoma japonicum Sjp_0311970   Vacuolar protein sorting-associated protein 53 homolog, putative
Schistosoma japonicum Sjp_0111350   Vacuolar protein sorting-associated protein 53 homolog, putative
Schistosoma japonicum Sjp_0079280   Long-chain-fatty-acid--CoA ligase 5, putative
Schistosoma japonicum Sjp_0006900   ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative
Schistosoma japonicum Sjp_0079200   Long-chain-fatty-acid--CoA ligase 5, putative
Schistosoma japonicum Sjp_0300720   ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative
Schistosoma japonicum Sjp_0053110   Long-chain-fatty-acid--CoA ligase 5, putative
Schistosoma japonicum Sjp_0088940   Long-chain-fatty-acid--CoA ligase 5, putative
Schistosoma japonicum Sjp_0300380   expressed protein
Schistosoma mansoni Smp_175090.3   FAA1 Long-chain-fatty-acid--CoA ligase 1
Schistosoma mansoni Smp_103160.1   long-chain-fatty-acid--CoA ligase
Schistosoma mansoni Smp_138660   long-chain-fatty-acid--CoA ligase
Schistosoma mansoni Smp_168050   long-chain-fatty-acid--CoA ligase
Schistosoma mansoni Smp_175090.2   long-chain-fatty-acid--CoA ligase
Schistosoma mansoni Smp_175090.1   long-chain-fatty-acid--CoA ligase
Schistosoma mansoni Smp_103160.2   long-chain-fatty-acid--CoA ligase
Schistosoma mansoni Smp_125560   long-chain-fatty-acid--CoA ligase
Schmidtea mediterranea mk4.003093.07   Lethal
Schmidtea mediterranea mk4.002149.00   Lethal
Schmidtea mediterranea mk4.000402.00   FAA4 Long-chain-fatty-acidALQ-CoA ligase 4
Schmidtea mediterranea mk4.000402.02  
Schmidtea mediterranea mk4.023586.00   FAA4 Long-chain-fatty-acidALQ-CoA ligase 4
Schmidtea mediterranea mk4.004159.00  
Schmidtea mediterranea mk4.005695.00  
Trypanosoma brucei gambiense Tbg972.9.2220   fatty acyl CoA synthetase 4, putative
Trypanosoma brucei gambiense Tbg972.9.2190   fatty acyl CoA syntetase 1, putative
Trypanosoma brucei gambiense Tbg972.9.2200   fatty acyl CoA synthetase 2
Trypanosoma brucei gambiense Tbg972.9.2210   fatty acyl CoA synthetase 3
Trypanosoma brucei gambiense Tbg972.10.4110   fatty acyl CoA synthetase, putative,Long-chain- fatty-acid--CoA ligase 4, putative
Trypanosoma brucei Tb927.9.4200   fatty acyl CoA synthetase 2
Trypanosoma brucei Tb927.9.4210   fatty acyl CoA synthetase 3
Trypanosoma brucei Tb11.v5.0561   fatty acyl CoA synthetase, putative
Trypanosoma brucei Tb927.10.3260   Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5), putative
Trypanosoma brucei Tb927.9.4230   fatty acyl CoA synthetase 4
Trypanosoma brucei Tb11.v5.0825   fatty acyl CoA synthetase, putative
Trypanosoma brucei Tb927.9.4190   fatty acyl CoA syntetase 1
Trypanosoma congolense TcIL3000_9_1300   Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5), putative
Trypanosoma congolense TcIL3000_10_2700   Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5), putative
Trypanosoma congolense TcIL3000_9_1350   fatty acyl CoA synthetase 4, putative
Trypanosoma congolense TcIL3000_9_1330   fatty acyl CoA synthetase 2, putative
Trypanosoma cruzi TcCLB.503575.50   fatty acyl CoA synthetase, putative
Trypanosoma cruzi TcCLB.504177.20   fatty acyl CoA synthetase 2, putative
Trypanosoma cruzi TcCLB.494675.10   fatty acyl CoA synthetase 2, putative
Trypanosoma cruzi TcCLB.506829.100   fatty acyl CoA syntetase 1, putative
Trypanosoma cruzi TcCLB.506829.110   fatty acyl CoA synthetase 2, putative
Trypanosoma cruzi TcCLB.510151.19   fatty acyl CoA syntetase 1, putative
Trypanosoma cruzi TcCLB.506261.10   fatty acyl CoA synthetase 2, putative
Trypanosoma cruzi TcCLB.510943.33   fatty acyl CoA synthetase, putative
Toxoplasma gondii TGME49_247760   AMP-binding enzyme domain-containing protein
Theileria parva TP01_0119   long-chain fatty acid CoA ligase, putative
Theileria parva TP01_0520   long-chain fatty acid CoA ligase, putative
Trichomonas vaginalis TVAG_464410   AMP dependent ligase/synthetase, putative
Trichomonas vaginalis TVAG_320050   AMP dependent CoA ligase, putative
Trichomonas vaginalis TVAG_059030   AMP dependent ligase/synthetase, putative
Trichomonas vaginalis TVAG_069460   AMP dependent ligase, putative
Trichomonas vaginalis TVAG_440450   AMP dependent ligase, putative
Trichomonas vaginalis TVAG_487910   long-chain-fatty-acid CoA ligase, putative
Trichomonas vaginalis TVAG_337850   AMP dependent CoA ligase, putative
Trichomonas vaginalis TVAG_340550   AMP dependent ligase, putative
Trichomonas vaginalis TVAG_481370   AMP dependent ligase/synthetase, putative
Trichomonas vaginalis TVAG_405380   long-chain-fatty-acid CoA ligase, putative
Trichomonas vaginalis TVAG_123810   AMP dependent ligase/synthetase, putative

Essentiality

LmjF.01.0470 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2634 Mycobacterium tuberculosis non-essential nmpdr
Tb09.160.2780 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.2780 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.160.2780 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.2780 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb09.160.2770 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.2770 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb09.160.2770 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.2770 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb09.160.2840 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.2840 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.160.2840 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.2840 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb09.160.2810 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.2810 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.160.2810 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.2810 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.3260 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.3260 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.3260 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.3260 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C46F4.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F37C12.7 Caenorhabditis elegans embryonic lethal wormbase
TGME49_247760 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3


Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Yersinia pestis AMP-binding enzyme family protein 525 aa 23.8% 488 aa Compounds References

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • Assay for Acyl Coenzyme A Synthetase (6.2.1.3 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

2 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.01.0470 (Leishmania major), fatty acyl CoA syntetase 1, putative
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