Detailed view for Smp_057840

Basic information

TDR Targets ID: 283777
Schistosoma mansoni, beta-14-galactosyltransferase
Source Database / ID:  GeneDB

pI: 10.0623 | Length (AA): 296 | MW (Da): 35363 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01199   Ribosomal protein L34e
PF02709   N-terminal domain of galactosyltransferase
PF13733   N-terminal region of glycosyl transferase group 7

Gene Ontology

Mouse over links to read term descriptions.
GO:0016757   transferase activity, transferring glycosyl groups  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  
GO:0005975   carbohydrate metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 218 2fy7 (A) 165 386 42.00 0 1 1.31092 -0.98

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130585)

Species Accession Gene Product
Brugia malayi Bm1_02765   Galactosyltransferase family protein
Drosophila melanogaster Dmel_CG8536   CG8536 gene product from transcript CG8536-RA
Echinococcus granulosus EgrG_000677850   Ribosomal protein L34a
Echinococcus granulosus EgrG_000925200   Metazoa galactosyltransferase
Echinococcus multilocularis EmuJ_000925200   Metazoa galactosyltransferase
Echinococcus multilocularis EmuJ_000677850   Ribosomal protein L34a
Echinococcus multilocularis EmuJ_000025500   Metazoa galactosyltransferase
Homo sapiens ENSG00000086062   UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Homo sapiens ENSG00000117411   UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
Loa Loa (eye worm) LOAG_08675   galactosyltransferase
Mus musculus ENSMUSG00000028413   UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Mus musculus ENSMUSG00000028541   UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
Schistosoma japonicum Sjp_0089080   Beta-1,4-galactosyltransferase 2, putative
Schistosoma japonicum Sjp_0303430   ko:K01805 xylose isomerase [EC5.3.1.5], putative
Schistosoma japonicum Sjp_0307070   ko:K02915 large subunit ribosomal protein L34e, putative
Schistosoma japonicum Sjp_0108110   expressed protein
Schistosoma mansoni Smp_021370   beta-14-galactosyltransferase
Schistosoma mansoni Smp_057840   beta-14-galactosyltransferase
Schmidtea mediterranea mk4.001916.02   Beta-1,4-N-acetylgalactosaminyltransferase bre-4
Schmidtea mediterranea mk4.040259.00  
Schmidtea mediterranea mk4.001210.01   Putative beta-1,4-galactosyltransferase
Schmidtea mediterranea mk4.025361.00  
Schmidtea mediterranea mk4.017668.00  
Schmidtea mediterranea mk4.024171.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Bos taurus Beta-1,4-galactosyltransferase 1 Compounds References
Homo sapiens UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0086 0.3445 0.4365
0.0174 0.9538 0.9538
0.009 1 1
0.0248 0.3398 0.7968
0.0267 0.5288 0
0.0146 0.527 0.5677
0.0146 0.527 0.5677
0.0146 1 0.5
0.0089 0.369 1
0.0172 1 1
0.0172 1 1
0.0248 0.3398 0.7968
0.0175 0.3054 0.7398
0.0193 0.3591 0.6643
0.0184 0.3356 0.5921
0.0191 1 1
0.0174 0.713 0.9117
0.022 1 1
0.0086 0.4935 1
0.0185 0.3068 0.3064
0.0085 0.3181 0.4329
0.0085 1 1
0.0187 0.2856 0.2807
0.0087 0.3089 0.4345
0.0176 0.75 1
0.0181 1 1
0.0174 1 1
0.0087 0.3346 0.4577
0.0166 0.2576 0.4304
0.0187 0.4922 1
0.0172 0.4433 0.657
0.0196 0.9533 0.9532
0.0061 0.3379 1
0.0177 0.7194 0.8901
0.0172 0.251 0.3713
0.0193 0.3593 0.6648
0.0185 0.3068 0.3064
0.0192 0.2556 0.278
0.0181 1 1
0.0086 0.3398 0.6977
0.018 1 1
0.0155 1 0.5
0.0183 0.5133 1
0.0174 0.3617 1
0.0183 1 0.5
0.0181 1 1
0.0106 0.3809 0.4869
0.0171 1 1
0.0106 0.9739 0
0.0155 1 0.5
0.0226 0.2508 1
0.0184 0.3552 0.6425
0.0173 0.4032 0.8269
0.0192 0.2556 0.278
0.0086 0.3445 0.4365
0.019 0.4267 0.9112
0.0186 0.3438 0.6095
0.0087 0.3346 0.4577
0.0086 0.3379 0.3506
0.0137 1 0.5
0.0175 0.4082 1
0.0137 1 0.5
0.0155 1 0.5
0.0137 1 0.5
0.0173 0.4366 0.6001
0.0172 0.4433 0.657
0.0192 0.2556 0.278
0.0106 1 1
0.0087 0.3089 0.4345
0.018 0.6461 0.6461
0.0085 0.2982 0.6176
0.0088 1 1
0.0189 0.4533 1
0.0185 0.3349 0.4751
0.0192 0.2556 0.278
0.0176 0.4492 1
0.017 0.4874 0.4874
0.0248 0.3398 0.7968
0.0174 0.4366 0.5999
0.0248 0.3398 0.7968
0.0172 1 1
0.0226 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_057840 (Schistosoma mansoni), beta-14-galactosyltransferase
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