Detailed view for Smp_131190

Basic information

TDR Targets ID: 283785
Schistosoma mansoni, diacylglycerol kinase zeta iota
Source Database / ID:  GeneDB

pI: 4.7399 | Length (AA): 419 | MW (Da): 47360 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00609   Diacylglycerol kinase accessory domain
PF00781   Diacylglycerol kinase catalytic domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016301   kinase activity  
GO:0004143   diacylglycerol kinase activity  
GO:0003951   NAD+ kinase activity  
GO:0008152   metabolic process  
GO:0007205   activation of protein kinase C activity  
GO:0007165   signal transduction  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 290 2bon (B) 60 297 24.00 0 0.58 0.586665 0.24
20 111 2qvl (A) 62 168 31.00 0.0022 0.65 0.48017 0.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131158)

Species Accession Gene Product
Brugia malayi Bm1_42420   Eye-specific diacylglycerol kinase
Caenorhabditis elegans CELE_K06A1.6   Protein DGK-5
Drosophila melanogaster Dmel_CG42667   retinal degeneration A
Echinococcus granulosus EgrG_000088500   Diacylglycerol kinase zeta
Echinococcus multilocularis EmuJ_000088500   Diacylglycerol kinase zeta
Homo sapiens ENSG00000157680   diacylglycerol kinase, iota
Homo sapiens ENSG00000149091   diacylglycerol kinase, zeta
Loa Loa (eye worm) LOAG_07975   eye-specific diacylglycerol kinase
Loa Loa (eye worm) LOAG_00404   hypothetical protein
Mus musculus ENSMUSG00000038665   diacylglycerol kinase, iota
Mus musculus ENSMUSG00000040479   diacylglycerol kinase zeta
Schistosoma japonicum Sjp_0079850   Diacylglycerol kinase iota, putative
Schistosoma japonicum Sjp_0041190   ko:K00901 diacylglycerol kinase [EC2.7.1.107], putative
Schistosoma mansoni Smp_131190   diacylglycerol kinase zeta iota
Schmidtea mediterranea mk4.016602.00  
Schmidtea mediterranea mk4.012330.00  
Schmidtea mediterranea mk4.004074.03   Diacylglycerol kinase
Schmidtea mediterranea mk4.003392.02   Putative diacylglycerol kinase, zeta, iota
Schmidtea mediterranea mk4.003392.00   Diacylglycerol kinase
Schmidtea mediterranea mk4.004736.00  
Schmidtea mediterranea mk4.004074.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_131190 (Schistosoma mansoni), diacylglycerol kinase zeta iota
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