Detailed view for Smp_146840

Basic information

TDR Targets ID: 283830
Schistosoma mansoni, netrin
Source Database / ID:  GeneDB

pI: 8.7876 | Length (AA): 741 | MW (Da): 86017 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00053   Laminin EGF domain
PF00055   Laminin N-terminal (Domain VI)
PF01759   UNC-6/NTR/C345C module

Gene Ontology

Mouse over links to read term descriptions.
GO:0005578   proteinaceous extracellular matrix  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
74 524 4aqs (A) 30 461 34.00 0 1 0.762037 0.91
77 462 4aqt (A) 42 395 37.00 0 1 0.777318 0.58
458 502 5lf2 (A) 781 824 52.00 0.00000081 1 0.678129 -0.23
492 521 2mny (A) 325 356 50.00 0.3 0.54 0.601886 -0.73

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129792)

Species Accession Gene Product
Brugia malayi Bm1_40270   Unc-6 protein precursor
Caenorhabditis elegans CELE_F41C6.1   Protein UNC-6
Drosophila melanogaster Dmel_CG18657   Netrin-A
Drosophila melanogaster Dmel_CG10521   Netrin-B
Echinococcus granulosus EgrG_000638000   netrin 1
Echinococcus multilocularis EmuJ_000638000   netrin 1
Echinococcus multilocularis EmuJ_000036400   transfer RNA-Gln
Homo sapiens ENSG00000162068   netrin 3
Homo sapiens ENSG00000065320   netrin 1
Loa Loa (eye worm) LOAG_03694   hypothetical protein
Loa Loa (eye worm) LOAG_03693   hypothetical protein
Mus musculus ENSMUSG00000079662   netrin 3
Mus musculus ENSMUSG00000020902   netrin 1
Schistosoma japonicum Sjp_0085590   IPR008993,TIMP-like OB-fold,domain-containing
Schistosoma japonicum Sjp_0312620   expressed protein
Schistosoma japonicum Sjp_0096540   Netrin-1 precursor, putative
Schistosoma japonicum Sjp_0314930   IPR008211,Laminin, N-terminal,domain-containing
Schistosoma japonicum Sjp_0103020   Netrin unc-6 precursor, putative
Schistosoma japonicum Sjp_0032870   Netrin-A precursor, putative
Schistosoma japonicum Sjp_0032860   Netrin-2 precursor, putative
Schistosoma mansoni Smp_146840   netrin
Schistosoma mansoni Smp_151310   netrin
Schmidtea mediterranea mk4.011645.00   Netrin unc-6
Schmidtea mediterranea mk4.000912.01  
Schmidtea mediterranea mk4.000912.00   Netrin unc-6
Schmidtea mediterranea mk4.004445.01   Netrin unc-6
Schmidtea mediterranea mk4.007143.02   Netrin unc-6
Schmidtea mediterranea mk4.001822.02  
Schmidtea mediterranea mk4.004838.01  
Schmidtea mediterranea mk4.001822.01   Netrin unc-6
Schmidtea mediterranea mk4.009796.01  
Schmidtea mediterranea mk4.003244.00   Netrin 1
Schmidtea mediterranea mk4.008235.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0587 0.7308 0.8336
0.0514 0.6074 0.6074
0.0043 0.2503 0.2503
0.0334 0.7132 1
0.0358 0.709 1
0.0273 0.7115 1
0.0231 0.6551 1
0.0514 0.6074 0.6074
0.0587 0.7308 0.8336
0.0455 0.7399 1
0.0495 0.5004 1
0.0753 0.2613 0.3627
0.0598 0.7324 1
0.0123 0.4913 1
0.0539 0.3272 0.6436
0.0587 0.7308 0.8336
0.0443 0.6001 1
0.0291 0.6551 1
0.0231 0.6551 1
0.0273 0.7115 1
0.0103 0.54 0.54
0.0363 0.5411 1
0.0192 0.6551 1
0.0408 0.7208 1
0.0186 0.4207 1
0.058 0.3769 0.3769
0.0484 0.6656 1
0.0224 0.7312 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_146840 (Schistosoma mansoni), netrin
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