Detailed view for PF3D7_1453800

Basic information

TDR Targets ID: 2841
Plasmodium falciparum, glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase

Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.8283 | Length (AA): 910 | MW (Da): 106987 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00479   Glucose-6-phosphate dehydrogenase, NAD binding domain
PF01182   Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
PF02781   Glucose-6-phosphate dehydrogenase, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005575   cellular_component  
GO:0050661   NADP binding  
GO:0017057   6-phosphogluconolactonase activity  
GO:0005488   binding  
GO:0004345   glucose-6-phosphate dehydrogenase activity  
GO:0003824   catalytic activity  
GO:0055114   oxidation reduction  
GO:0008152   metabolic process  
GO:0006098   pentose-phosphate shunt  
GO:0006006   glucose metabolic process  
GO:0005975   carbohydrate metabolic process  

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 295 1ne7 (A) 1 251 17.00 0 0.99 0.43 -1.11
19 292 2bkx (A) 1 241 16.00 0 1 0.38 -0.94
336 886 1dpg (A) 3 481 26.00 0 1 0.73 -0.68
8 320 3e15 (A) 8 297 75.00 0 1 1.25206 -1.6
335 891 2bh9 (A) 28 509 41.00 0 1 0.941088 0.12
336 894 4lgv (A) 7 463 30.00 0 1 0.744286 0.21

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

  • 3.00E+01:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 48 hs, merozoite, early ring. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, sporozoite, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Sporozoite. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile gametocyte, Male Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Female Gametocyte. Lasonder E
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_127121)

Species Accession Gene Product
Arabidopsis thaliana AT5G40760   glucose-6-phosphate dehydrogenase 6
Arabidopsis thaliana AT1G24280   glucose-6-phosphate dehydrogenase 3
Arabidopsis thaliana AT3G27300   glucose-6-phosphate dehydrogenase 5
Arabidopsis thaliana AT5G35790   glucose-6-phosphate dehydrogenase 1
Arabidopsis thaliana AT5G13110   glucose-6-phosphate dehydrogenase 2
Babesia bovis BBOV_IV001600   glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
Brugia malayi Bm1_36755   glucose-6-phosphate dehydrogenase
Candida albicans CaO19.12218   likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C)
Candida albicans CaO19.4754   likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C)
Caenorhabditis elegans CELE_B0035.5   Protein GSPD-1
Chlamydia trachomatis CT_185   glucose-6-phosphate 1-dehydrogenase
Dictyostelium discoideum DDB_G0273639   glucose 6-phosphate-1-dehydrogenase
Dictyostelium discoideum DDB_G0273131   glucose 6-phosphate-1-dehydrogenase
Drosophila melanogaster Dmel_CG12529   Zwischenferment
Drosophila melanogaster Dmel_CG7140   CG7140 gene product from transcript CG7140-RB
Escherichia coli b1852   glucose-6-phosphate 1-dehydrogenase
Echinococcus granulosus EgrG_000126400   glucose 6 phosphate 1 dehydrogenase
Echinococcus multilocularis EmuJ_000126400   glucose 6 phosphate 1 dehydrogenase
Giardia lamblia GL50803_8682   Glucose-6-phosphate 1-dehydrogenase
Homo sapiens ENSG00000160211   glucose-6-phosphate dehydrogenase
Leishmania braziliensis LbrM.20.0160   glucose-6-phosphate 1-dehydrogenase, putative
Leishmania donovani LdBPK_340080.1   glucose-6-phosphate 1-dehydrogenase, putative
Leishmania infantum LinJ.34.0080   glucose-6-phosphate 1-dehydrogenase, putative
Leishmania major LmjF.34.0080   glucose-6-phosphate 1-dehydrogenase, putative
Leishmania mexicana LmxM.33.0080   glucose-6-phosphate dehydrogenase
Loa Loa (eye worm) LOAG_04956   glucose-6-phosphate dehydrogenase
Mus musculus ENSMUSG00000089992   glucose-6-phosphate dehydrogenase 2
Mus musculus ENSMUSG00000031400   glucose-6-phosphate dehydrogenase X-linked
Mycobacterium tuberculosis Rv1447c   Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD)
Mycobacterium ulcerans MUL_1842   glucose-6-phosphate 1-dehydrogenase
Neospora caninum NCLIV_068740   Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related
Neospora caninum NCLIV_067180   Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related
Oryza sativa 4336209   Os04g0485300
Oryza sativa 4342988   Os07g0406300
Oryza sativa 4333103   Os03g0412800
Oryza sativa 4329889   Os02g0600400
Plasmodium berghei PBANKA_1317500   glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative
Plasmodium falciparum PF3D7_1453800   glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
Plasmodium knowlesi PKNH_1228300   glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative
Plasmodium vivax PVX_117790   glucose-6-phosphate 1-dehydrogenase, putative
Plasmodium yoelii PY00793   Glucose-6-phosphate dehydrogenase, putative
Saccharomyces cerevisiae YNL241C   glucose-6-phosphate dehydrogenase
Schistosoma japonicum Sjp_0026090   ko:K00036 glucose-6-phosphate 1-dehydrogenase [EC1.1.1.49], putative
Schistosoma mansoni Smp_052810   glucose-6-phosphate 1-dehydrogenase
Schmidtea mediterranea mk4.062629.00  
Schmidtea mediterranea mk4.053429.00  
Schmidtea mediterranea mk4.014447.00   Glucose-6-phosphate 1-dehydrogenase
Schmidtea mediterranea mk4.025737.00   Glucose-6-phosphate 1-dehydrogenase
Schmidtea mediterranea mk4.011860.01   Glucose-6-phosphate 1-dehydrogenase
Schmidtea mediterranea mk4.045079.00   Glucose-6-phosphate 1-dehydrogenase
Schmidtea mediterranea mk4.062629.01   Putative 6-phosphogluconolactonase
Trypanosoma brucei gambiense Tbg972.10.3100   glucose-6-phosphate 1-dehydrogenase, putative
Trypanosoma brucei Tb927.10.2490   glucose-6-phosphate 1-dehydrogenase
Trypanosoma congolense TcIL3000_10_2120   glucose-6-phosphate 1-dehydrogenase, putative
Trypanosoma cruzi TcCLB.509287.50   glucose-6-phosphate 1-dehydrogenase, putative
Toxoplasma gondii TGME49_278830   glucose-6-phosphate 1-dehydrogenase
Treponema pallidum TP0478   glucose-6-phosphate 1-dehydrogenase
Theileria parva TP03_0558   glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative
Trichomonas vaginalis TVAG_414060   glucosamine-6-phosphate isomerase, putative
Trichomonas vaginalis TVAG_094630   glucosamine-6-phosphate isomerase, putative
Trichomonas vaginalis TVAG_089600   6-phosphogluconolactonase, putative

Essentiality

PF3D7_1453800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.2490 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.2490 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.2490 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.2490 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b1852 Escherichia coli essential goodall
CELE_B0035.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_B0035.5 Caenorhabditis elegans slow growth wormbase
CELE_B0035.5 Caenorhabditis elegans sterile wormbase
YNL241C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1317500 Plasmodium berghei Slow plasmo
TGME49_278830 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Trypanosoma brucei gambiense glucose-6-phosphate 1-dehydrogenase, putative Compounds References
Homo sapiens glucose-6-phosphate dehydrogenase Compounds References
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase Compounds References
Plasmodium falciparum Glucose-6-phosphate 1-dehydrogenase Compounds References
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Compounds References
Saccharomyces cerevisiae glucose-6-phosphate dehydrogenase Compounds References
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0654692 0.275057 1
0.1052 1 1
0.0123 0.5131 1
0.0131 0.6413 0
0.1686 0.6658 1
0.3249 0.5389 1
0.0644 0.5128 1
0.0866 0.3785 1
0.01 0.405 1
0.2908 0.4923 1
0.0099 0.3108 1
0.0123 0.3244 0.2935
0.2863 0.286 1
0.2764 0.4716 1
0.0098 0.3406 0.3038
0.2764 0.4716 1
0.0355 0.3301 1
0.0119 0.4513 0.5556
0.0224 0.7893 1
0.1039 0.7054 0.7052
0.0123 0.3114 0.5507
0.0248 0.2963 1
0.0319 0.3277 0.5702
0.0482 0.2506 1
0.2588 0.5109 1
0.0273 0.8155 1
0.0121 0.278 0.2868
0.2607 0.4624 1
0.0273 1 1
0.147 0.8586 1
0.0123 0.9007 1
0.1701 0.2932 1
0.0221 0.2566 1
0.0273 1 1
0.0101 0.4478 1
0.0852 0.309 1
0.0438 0.5205 1
0.0118 0.2517 0.2402
0.0123 0.5913 1
0.0123 0.2703 1
0.2311 0.4709 1
0.0856 0.5243 0.5233
0.1082 0.7205 0.7203
0.012 0.5567 1
0.1029 0.9696 1
0.2908 0.4923 1
0.0633 0.4605 1
0.01 0.2518 1
0.0455 0.6936 1
0.1132 0.684 0.8963
0.1387 0.7868 0.8854
0.0473 0.5842 1
0.0654692 0.275057 1
0.015 1 1
0.0201 0.5236 1
0.142 0.2822 1
0.0367 0.4032 1
0.1333 0.4091 1
0.0108 0.2778 1
0.0641 0.4191 1
0.015 0.6667 0.5
0.01 0.2662 0.0432
0.01 0.3842 0.554
0.0238 0.3096 1
0.0482 0.2507 1
0.0491 0.4178 1
0.3275 0.4237 1
0.0963 0.3525 1
0.0921 0.3521 1
0.0176 0.6564 1
0.1035 0.7268 0.1823
0.0102 0.3559 0.5415
0.142 0.2822 1
0.0498 0.9913 1
0.048 0.592 1
0.0326 0.331 0.6458
0.045 0.6579 0.6579
0.0273 0.308 1
0.0353 0.3502 1
0.0882 0.3523 1
0.0112 0.5884 1
0.1339 0.3176 1
0.0915 0.2845 1
0.0101 0.4021 1
0.0688577 0.280645 1
0.0637 0.2554 1
0.1037 1 1
0.338 0.5008 1
0.0911 0.2679 1
0.0891 0.8092 1
0.0708 0.6821 1
0.3055 0.6111 1
0.0616 0.2561 1
0.0322 0.4138 0.8016
0.0101 0.3567 1
0.0098 0.3514 0.1058
0.0963 0.3519 1
0.0949 0.4229 1
0.0461 0.5238 1
0.0464 0.6484 1
0.0915 0.2845 1
0.0273 1 1
0.0963 0.3513 1
0.0675 0.4733 1
0.045 0.309 0.3069
0.0684 0.4889 1
0.0345 0.5402 1
0.0362 0.4448 1
0.0123 0.2662 1
0.0963 0.3545 1
0.3156 0.5323 1
0.0635 0.2975 1
0.0122 0.3376 0.5
0.0921 0.3522 1
0.0102 0.3194 1
0.0794 0.7183 1
0.0588 0.5383 1
0.0389 1 0.5
0.0107 0.448 0.5556
0.0921 0.3521 1
0.0367 0.4042 1
0.0557 0.5627 0.6984
0.0702 0.2802 1
0.01 0.2772 1
0.0882 0.3534 1
0.0098 0.2878 0.2954
0.1098 0.6793 0.6471
0.0123 0.3571 0.5432
0.3181 0.8943 1
0.0123 0.5718 1
0.0453 0.6623 1
0.1928 0.7767 1
0.0123 1 1
0.3181 0.8943 1
0.01 0.5816 1
0.0123 1 1
0.0123 0.2914 1
0.0123 0.2914 1
0.0273 0.3066 1
0.2533 0.2702 0.583
0.3275 0.4237 1
0.2775 0.4072 1
0.013 1 0.5
0.0629 0.2845 1
0.2012 0.494 0.9397
0.0102 0.2857 1
0.0123 0.2801 1
0.1039 0.454 0.8462
0.1 0.2709 1
0.0232 0.3145 1
0.0123 0.2728 1
0.0273 0.7739 1
0.0066 0.2965 0.5415
0.0691 0.4977 1
0.279 0.8429 1
0.0629 0.5819 1
0.0273 0.3109 1
0.102 0.7397 1
0.0882 0.353 1
0.0111 0.2728 0.0432
0.1996 0.8138 1
0.0702 0.3997 1
0.0482 0.2525 1
0.0626 0.3641 1
0.0367 0.3332 1
0.1039 0.7289 0.7897
0.0114 0.2675 1
0.0098 0.4093 1
0.0273 1 1
0.0101 0.2662 0.0432
0.0214 0.3065 0.5734
0.0293 0.3479 1
0.0839 0.3619 1
0.1039 0.454 0.8462
0.066 1 1
0.0225 0.2638 1
0.0105 0.2703 1
0.0742 0.3122 1
0.0123 0.3235 0.3271
0.044 0.8088 1
0.0115 0.3685 1
0.1547 0.4686 1
0.015 1 1
0.0129 0.5175 0.5
0.0123 0.2871 1
0.0123 0.2551 1
0.0207 0.4267 1
0.0921 0.2829 1
0.1913 0.5152 0.9824
0.0117 0.3993 1
0.0375 0.3822 1
0.0438 0.5205 1
0.0103 0.4529 1
0.0123 1 1
0.0336 0.4126 1
0.0621 0.6181 1
0.0102 0.2857 1
0.0963 0.3525 1
0.0121 0.278 0.2868
0.0698 0.8655 1
0.0215 0.3229 1
0.049 0.3248 1
0.0637 0.2554 1
0.015 0.6667 0.5
0.0122 0.2824 1
0.0122 0.2824 1
0.0921 0.2829 1
0.3281 0.4801 1
0.0101 0.2662 0.0432
0.1039 0.7244 0.791
0.0123 0.3077 1
0.072 0.255 1
0.1122 0.6787 0.6592
0.0112 0.2763 1
0.0123 0.2518 1
0.0258 0.2538 1
0.0481 0.4085 1
0.1205 0.4769 1
0.3155 0.4716 1
0.01 0.2589 1
0.1082 0.727 0.7663
0.0123 1 1
0.2012 0.494 0.9397
0.0991 1 1
0.015 0.2579 0.5
0.0608 0.2631 1
0.2488 0.4916 1
0.0644 0.2864 1
0.0367 0.3996 0.8939
0.0415 0.3852 0.7533
0.0702 0.3225 1
0.0082 0.4513 0.5556
0.0227 0.3207 1
0.3234 0.6355 1
0.0336 0.4126 1
0.0123 0.3278 1
0.0637 0.256 1
0.0367 0.3996 0.8939
0.1273 0.9891 1
0.0913 0.3807 1
0.0616 0.2579 1
0.0891 0.3763 1
0.3172 0.5458 1
0.0637 0.9435 1
0.0659 0.4747 0.6069
0.2689 0.7782 1
0.0143 0.2857 0.5
0.0204 0.3232 1
0.0104 0.2763 1
0.0878 0.5227 0.4906
0.0273 0.2719 1
0.0101 0.3915 1
0.0111 0.3842 0.554
0.0273 0.3079 1
0.326 0.6499 1
0.1971 0.4174 1
0.0452 0.4937 0.492
0.0099 0.3091 0.5133
0.3103 0.6168 1
0.0882 0.3522 1
0.0099 0.6038 1
0.1926 0.7455 1
0.0111 0.3842 0.554
0.0104 0.5461 0.1261
0.0273 0.8086 1
0.0123 0.3968 0.5415
0.0963 0.3516 1
0.0684 0.5569 1
0.0273 0.3066 1
0.0118 0.3081 0.554
0.1019 0.7315 0.8363
0.0258 0.3096 1
0.0916 1 1
0.0914 1 1
0.0216 0.3323 1
0.013 1 0.5
0.2067 0.4975 1
0.015 0.5606 0.5
0.0972 0.2833 1
0.0616 0.2563 1
0.0927 0.7061 0.7531
0.0135 0.3809 0.5
0.2024 0.8181 1
0.0921 0.2828 1
0.0486 0.2837 1
0.0236 0.4404 0.6911
0.0123 0.8286 1
0.0495 0.2941 1
0.015 1 0.5
0.0621 0.6181 1
0.045 0.6135 1
0.0933 0.3568 1
0.1001 1 1
0.1923 0.5927 1
0.0123 0.3194 1
0.0858 0.2542 1
0.1806 0.3158 1
0.0482 0.254 1
0.2908 0.4923 1
0.022 0.3145 1
0.3231 0.494 1
0.1817 0.3177 1
0.2865 0.4768 1
0.0123 0.2613 1
0.0612 0.5498 1
0.0879 0.3688 1
0.0429 0.6135 1
0.0227 0.2655 1
0.0123 0.317 1
0.3172 0.5458 1
0.0236 0.2584 0.2509
0.3229 0.4851 1
0.0123 0.4478 1
0.0104 0.2787 1
0.0921 0.3521 1
0.0654692 0.275057 1
0.0778 0.7279 1
0.0108 0.5827 0.1547
0.3281 0.4801 1
0.0616 0.2561 1
0.0232 0.3145 1
0.0105 0.4093 1
0.0817 0.3325 1
0.2426 0.5749 1
0.0367 0.4372 1
0.0367 0.33 1
0.0882 0.3523 1
0.032001 0.273765 1
0.0644 0.2864 1
0.0234 0.2793 1
0.0668 0.7625 1
0.0273 0.5376 1
0.0108 0.2576 1
0.0915 0.257 1
0.2223 0.8246 1
0.0144 0.3446 1
0.0908 0.2563 1
0.1 0.2709 1
0.0087 0.3842 0.554
0.0879 0.3692 1
0.1052 1 1
0.0099 0.2703 1
0.0123 0.3054 1
0.021 0.2663 1
0.0123 0.3777 1
0.0102 0.3573 1
0.0222 0.3314 1
0.0273 0.6233 1
0.0921 0.2844 1
0.0102 0.3046 0.1186
0.095 0.5763 1
0.1155 0.6582 0.6715
0.0249 0.2631 1
0.0221 0.3205 1
0.0916 0.934 1
0.1072 0.736 0.7617
0.0608 0.2515 1
0.0083 0.5704 1
0.0106 0.2538 1
0.0226 0.609 1
0.0972 0.2833 1
0.0113 0.2582 1
0.0123 0.7148 1
0.171 1 1
0.012 0.2505 1
0.0123 0.2703 1
0.1549 0.2727 1
0.0273 0.7905 1
0.0109 0.3166 0.5415
0.068 0.9784 0.9784
0.0367 0.3689 1
0.0088 0.4122 0.561
0.074 0.3858 1
0.0635 0.8408 1
0.0484 0.3141 1
0.0608 0.2568 0.2824
0.0644 0.2864 1
0.0122 0.2914 0.0952
0.0742 0.3124 1
0.0554 0.4165 1
0.0099 0.5881 1
0.015 1 0.5
0.0644 0.3624 1
0.0099 0.5881 1
0.0436 0.3025 1
0.0099 0.3108 1
0.0433 1 1
0.0925 1 1
0.2166 0.2876 1
0.0273 0.7875 1
0.0123 0.3441 0.5556
0.2323 0.5777 1
0.0593 0.4972 1
0.0101 0.294 1
0.0115 0.3244 0.2981
0.2908 0.4923 1
0.0251 0.2631 1
0.0113 0.2585 1
0.0698 0.8655 1
0.1103 0.6365 0.6164
0.1102 0.3416 1
0.0106 0.3076 1
0.0915 0.2846 1
0.1427 0.3465 1
0.0882 0.3526 1
0.011 0.2886 1
0.0099 0.3108 1
0.0365 0.4138 1
0.0616 0.2561 1
0.0102 0.394 1
0.1205 0.4769 1
0.0434 0.3041 1
0.0654 0.3052 1
0.2311 0.4709 1
0.0112 0.5827 0.1977
0.3281 0.4801 1
0.0915 0.2846 1
0.2493 0.7608 1
0.0367 0.257 1
0.0882 0.3525 1
0.1644 0.8038 1
0.0925 0.9426 1
0.3129 0.7521 1
0.0127 1 0.5
0.0437 0.3096 1
0.062 0.3935 1
0.0946 0.2909 1
0.0437 0.3123 1
0.0729 0.3183 1
0.01 0.5827 1
0.0616 0.2557 1
0.1836 0.8161 1
0.0123 0.3393 0.5432
0.1072 0.7323 0.7881
0.1795 0.5419 1
0.2056 0.2735 1
0.012 0.2505 1
0.0966 0.2752 1
0.0123 0.5827 1
0.0921 0.3522 1
0.1012 0.7336 0.9638
0.1128 0.8242 0.9141
0.0109 0.2703 1
0.0268 0.2567 1
0.0273 0.3428 0.5413
0.0616 0.2561 1
0.0887 0.266 1
0.0214 0.4254 1
0.1806 0.5486 1
0.0367 0.4431 1
0.015 0.9905 0.5
0.0237 0.2631 1
0.0101 0.4478 1
0.0123 0.263 1
0.1068 0.7226 0.7282
0.0887 0.266 1
0.142 0.2822 1
0.0623 0.2947 1
0.0921 0.352 1
0.0882 0.3525 1
0.1107 0.718 0.7001
0.0951 0.337 1
0.0608 0.2568 0.2824
0.0616 0.2577 1
0.022 0.2573 1
0.0626 0.5537 1
0.0289 0.6855 1
0.0232 0.3145 1
0.0981 0.8105 1
0.0367 0.4032 1
0.0621 0.6181 1
0.0632 0.304 1
0.0273 0.3208 1
0.1122 0.6834 0.6776
0.0123 0.2884 1
0.0247 0.2585 1
0.0223 0.8188 1
0.3927 0.4858 1
0.0882 0.3534 1
0.1836 0.8161 1
0.0205 0.264 1
0.0253 0.2656 1
0.0123 0.3497 1
0.3035 0.6179 1
0.093 0.5808 1
0.0616 0.2561 1
0.011 0.5567 1
0.2067 0.4975 1
0.0102 0.3178 1
0.0101 0.2518 1
0.049 0.3248 1
0.0742 0.313 1
0.0753 0.3102 1
0.0121 0.278 0.2868
0.0837 0.7449 0.8075
0.0234 0.3595 1
0.0679 0.811 1
0.0958 0.3664 1
0.0294 0.347 1
0.2426 0.5749 1
0.0202 0.2685 1
0.0202 0.2676 1
0.0099 0.2861 1
0.0905 0.3566 1
0.0557 0.5627 0.6984
0.0222 0.4004 0.3872
0.0882 0.3535 1
0.0946 0.2909 1
0.0123 0.3235 0.3271
0.0123 1 0.5
0.2546 0.7403 1
0.0304 1 0.5
0.0879 0.3702 1
0.015 0.2579 0.5
0.338 0.5008 1
0.1072 0.7323 0.7881
0.2223 0.8246 1
0.0729 0.3431 1
0.045 0.6135 1
0.2692 0.6657 1
0.0103 0.3444 0.6774
0.0237 0.2616 1
0.0123 0.7985 1
0.0616 0.2579 1
0.1039 0.7054 0.7052
0.0742 0.3109 1
0.0569 0.3362 1
0.0227 0.254 1
0.0623 0.6032 1
0.1094 0.6766 0.6548
0.1327 1 1
0.0121 0.5869 1
0.1038 0.7858 1
0.0273 0.8092 1
0.0102 0.3159 1
0.0104 0.2662 1
0.0098 0.2662 0.0432
0.015 0.4658 0.5
0.0123 0.3842 0.554
0.0103 0.2767 1
0.0221 0.2651 1
0.0123 0.2501 1
0.0381147 1 0.5
0.0365 0.3437 1
0.0367 0.4431 1
0.142 0.2822 1
0.0456 0.2955 1
0.0596 0.3974 1
0.0921 0.2833 1
0.0233 0.2585 0.5683
0.1039 0.454 0.8462
0.0365 0.3365 1
0.2 0.81 0.9249
0.0258 0.3145 1
0.1998 0.812 1
0.1057 0.8144 0.8901
0.015 0.9905 0.5
0.2071 0.9132 1
0.3035 0.6179 1
0.1236 0.4957 1
0.0644 0.4368 1
0.0616 0.2553 1
0.2166 0.2876 1
0.0111 0.5564 1
0.0839 0.3619 1
0.0642 0.8984 1
0.0123 0.3393 0.5432
0.0115 0.2587 1
0.0221 0.2502 1
0.1398 0.7823 1
0.0116 0.2703 1
0.3064 0.7299 1
0.2681 0.3947 1
0.0227 0.2664 1
0.2908 0.4923 1
0.3228 0.4278 1
0.2565 0.3079 1
0.031 0.3055 0.556
0.0472 0.3135 1
0.142 0.2822 1
0.0098 0.3105 1
0.3263 0.5577 1
0.0483 0.6422 1
0.0123 0.2686 1
0.0123 0.3993 1
0.068 0.5728 1
0.0363 0.3199 1
0.0106 0.3067 1
0.0893 0.3575 1
0.0246 0.3037 1
0.0119 0.2583 1
0.0933 0.3567 1
0.0753 0.3101 1
0.0435 0.3956 0.7577
0.0554 0.2825 1
0.062 0.3981 1
0.1708 0.7948 1
0.011 0.8205 1
0.0902 0.3741 1
0.0117 0.3183 1
0.0095 0.4513 0.5556
0.1039 0.454 0.8462
0.0448 0.2736 1
0.0107 0.4355 1
0.0608 0.2633 1
0.0629 0.9112 1
0.2533 0.2702 0.583
0.0469 0.3731 0.373
0.0675 1 1
0.0264 0.2647 1
0.0753 0.2619 1
0.0261 0.3654 1
0.056 0.4941 1
0.0367 0.33 1
0.0621 0.6181 1
0.082 0.3126 1
0.0222 0.3314 1
0.0102 0.3072 1
0.015 0.2579 0.5
0.0108 0.2519 1
0.0377 1 1
0.0144 0.7557 0.5
0.1031 0.7265 0.8405
0.3035 0.6179 1
0.0794 0.7192 1
0.1331 0.5401 1
0.0498 0.9082 1
0.01 0.266 1
0.0123 0.3178 1
0.1482 0.8534 1
0.062 0.9198 1
0.2976 0.5891 1
0.0123 0.7456 1
0.0694 0.6824 0.6819
0.0949 0.4229 1
0.2829 0.8454 1
0.0778 0.7689 0.7689
0.0629 0.2852 1
0.0219 0.2664 1
0.0882 0.3524 1
0.0963 0.3533 1
0.0484 0.353 1
0.2775 0.4072 1
0.0273 0.8086 1
0.0411 0.7213 1
0.0241 0.307 1
0.0123 0.5704 1
0.1344 0.5432 1
0.045 0.6135 1
0.3249 0.5389 1
0.3369 0.4475 1
0.106 0.6992 0.696
0.3292 0.4917 1
0.0121 0.278 0.2868
0.027 0.2754 1
0.0652 0.6271 1
0.0613 0.3695 1
0.1509 0.7462 1
0.0616 0.2555 1
0.0215 0.3229 1
0.1008 0.7243 1
0.0921 0.3522 1
0.0642 0.3607 1
0.0273 0.3111 1
0.0273 0.661 1
0.0273 0.7386 1
0.0629 0.3246 1
0.1012 0.7336 0.9638
0.0946 0.3564 1
0.0273 0.4698 1
0.009 0.306 0.5432
0.2282 0.5363 1
0.011 0.5963 1
0.0367 0.3996 0.8939
0.1 0.2709 1
0.2783 0.4097 1
0.0098 0.2632 1
0.015 1 0.5
0.0247 0.2631 1
0.2426 0.5749 1
0.3103 0.6166 1
0.0209 0.2715 1
0.0361 0.5548 1
0.246 0.9846 1
0.1971 0.475 1
0.0441 0.3337 0.7347
0.1089 0.7068 0.6979
0.0632 0.593 1
0.0104 0.3191 0.5124
0.0123 0.3059 0.5432
0.0495 0.384 1
0.0123 0.2937 0.5432
0.0963 0.3519 1
0.0554 0.4165 1
0.1011 0.7278 0.9628
0.0125 0.8075 1
0.2607 0.4624 1
0.0238 0.3096 1
0.0273 1 1
0.0123 0.5748 1
0.0377 1 1
0.0941 0.3714 1
0.0958 0.3664 1
0.0345 0.5402 1
0.0117 0.3177 1
0.1327 1 1
0.2952 0.9372 1
0.0482 0.254 1
0.0672 0.9816 1
0.0273 0.3066 1
0.0753 0.3103 1
0.0569 0.3362 1
0.0702 0.3997 1
0.0665 0.8114 1
0.0616 0.3691 1
0.0449 0.8091 1
0.0495 0.384 1
0.0492 0.2875 1
0.0273 1 1
0.0099 0.3487 1
0.0099 0.2586 1
0.0632 0.2766 1
0.0491 1 1
0.0105 0.3474 0.5677
0.0222 0.4273 1
0.1482 0.8534 1
0.045 0.6135 1
0.0433 1 1
0.0623 0.2862 1
0.0659 0.2772 0.9763
0.2425 0.3115 1
0.0311 0.3378 0.5684
0.01 0.5827 1
0.072 0.3392 1
0.1703 0.5274 1
0.311 0.9566 1
0.0237 0.2613 1
0.0709 0.4043 1
0.0202 0.2685 1
0.0632 0.2766 1
0.0742 0.2892 1
0.0915 0.2846 1
0.0101 0.5123 0.1119
0.0111 0.2758 1
0.3363 0.4909 1
0.0273 0.8086 1
0.0443 0.3204 1
0.0963 0.3525 1
0.0251 0.2536 1
0.074 0.3821 1
0.0263 0.2931 1
0.1019 0.7334 0.8456
0.072 0.4015 1
0.0237 0.2616 1
0.0109 0.294 1
0.0369 1 1
0.1708 0.7948 1
0.2425 0.3115 1
0.0652 0.6271 1
0.0921 0.2833 1
0.0229 0.2632 1
0.0388 0.6135 1
0.0105 0.294 1
0.3108 1 1
0.0127 1 0.5
0.0491 0.938 1
0.0098 1 1
0.0101 0.5286 0.1186
0.0121 0.278 0.2868
0.0222 0.4273 1
0.011 0.258 1
0.0921 0.352 1
0.0949 0.4229 1
0.0258 0.3145 1
0.011 0.3474 1
0.0105 0.405 0.1007
0.0987 1 1
0.0959 0.2836 1
0.0879 0.3712 1
0.2865 0.4768 1
0.0704 0.4882 1
0.0098 0.366 1
0.3241 0.7688 1
0.0495 0.6133 1
0.0644 0.3624 1
0.0123 0.2871 1
0.2489 0.9234 1
0.0637 0.2554 1
0.0483 0.6422 1
0.0123 0.3918 1
0.0482 0.2537 1
0.0709 0.504 1
0.1038 0.9735 1
0.0491 1 1
0.0654692 0.275057 1
0.1017 1 1
0.0205 0.4153 1
0.1082 0.727 0.7663
0.129 0.7314 0.7489
0.1018 0.7281 0.3124
0.01 0.3098 1
0.0616 0.2553 1
0.015 0.4658 0.5
0.0882 0.3528 1
0.1052 1 1
0.0498 0.3362 1
0.0232 0.3145 1
0.01 0.2555 1
0.0495 0.4746 0.8966
0.0252 0.2863 1
0.1023 0.7358 0.8387
0.0123 0.5212 1
0.0229 0.3554 1
0.0367 0.257 1
0.0621 0.6181 1
0.0409 0.3753 0.7558
0.0388 0.6135 1
0.0123 0.3102 1
0.0882 0.3521 1
0.025 0.3229 1
0.045 0.6749 0.6553
0.024 0.2631 1
0.0101 0.3685 1
0.0497 0.7318 1
0.0612 0.6315 1
0.0123 0.2558 1
0.0729 0.3801 1
0.0234 0.4484 1
0.1836 0.8161 1
0.0104 0.2763 1
0.1098 0.736 0.7619
0.0123 0.3842 0.554
0.2571 0.5188 1
0.078 0.3099 1
0.0616 0.2551 1
0.0221 0.3078 0.7022
0.0189 0.347 1
0.0281 0.3466 1
0.0481 0.4085 1
0.0882 0.3531 1
0.3017 0.5979 1
0.1387 0.7868 0.8854
0.0672 0.9816 1
0.1695 0.6924 1
0.2032 1 1
0.3311 0.4863 1
0.0852 0.5116 0.4857
0.3281 0.4801 1
0.0498 0.2598 1
0.0882 0.3524 1
0.0123 0.5567 1
0.0219 0.2569 1
0.3177 0.5315 1
0.0325 0.3393 1
0.1147 0.6871 0.6631
0.0106 0.3366 1
0.01 0.2662 0.0432
0.0121 0.278 0.2868
0.0207 0.4168 1
0.0623 1 1
0.0237 0.2613 1
0.0675 0.4431 1
0.3311 0.4452 1
0.2908 0.4923 1
0.1108 0.6403 0.6241
0.0632 0.2766 1
0.1004 0.7289 0.5191
0.1197 0.2911 1
0.1072 0.7265 0.7311
0.0106 0.2703 1
0.0862 0.5243 0.5242
0.0112 0.2582 1
0.015 0.4658 0.5
0.0223 0.5345 1
0.0123 0.3981 1
0.0554 0.4165 1
0.0273 0.3109 1
0.01 0.2639 1
0.0879 0.37 1
0.0719 0.2904 1
0.0122 0.279 1
0.066 1 1
0.045 0.6135 1
0.0315 0.4252 1
0.072 0.3392 1
0.0491 0.4178 1
0.0921 0.2832 1
0.0176 0.6564 1
0.0891 0.3756 1
0.1012 0.7336 0.9638
0.0151 0.6667 0.5
0.0608 0.2568 0.2824
0.0882 0.3528 1
0.0626 0.3585 1
0.01 0.253 0.554
0.0263 0.258 1
0.1077 0.4127 0.7145
0.0915 0.257 1
0.2972 0.6982 1
0.1536 0.6358 1
0.3099 0.95 1
0.0123 0.6195 1
0.0675 0.7922 1
0.3281 0.4801 1
0.0444 0.2715 1
0.0255 1 0.5
0.0416 1 1
0.0482 0.2507 1
0.015 0.8102 1
0.0365 0.3484 1
0.0082 0.4513 0.5556
0.062 0.3036 1
0.0963 0.3516 1
0.0879 0.3704 1
0.0227 0.2664 1
0.01 0.2575 0.5863
0.074 0.3894 1
0.0229 0.3574 1
0.0101 0.3028 1
0.0123 0.5131 1
0.0102 1 1
0.0616 0.2577 1
0.0753 0.3841 1
0.0123 0.3183 1
0.0614 1 1
0.0123 0.3392 1
0.0951 0.337 1
0.1026 1 1
0.0315 0.2698 1
0.0915 0.2846 1
0.0123 0.367 1
0.0121 0.278 0.2868
0.0228 0.7893 0.4874
0.2162 0.769 1
0.0367 0.2546 1
0.0966 0.2734 1
0.1934 0.9002 1
0.112 0.9259 1
0.045 0.6107 1
0.0624 1 1
0.0315 0.3178 0.5589
0.0742 0.2892 1
0.0681 0.7692 1
0.0107 0.3099 1
0.0273 1 1
0.1313 0.7698 1
0.0882 0.3523 1
0.0471 0.2802 1
0.0123 0.339 1
0.0209 0.3012 1
0.1004 0.3907 0.7662
0.0234 0.5103 0.0506
0.0242 0.2577 1
0.2999 0.9245 1
0.0684 0.475 1
0.0917 0.3671 1
0.0882 0.3526 1
0.0099 0.322 1
0.0882 0.3529 1
0.0486 0.5507 1
0.0915 0.2845 1
0.0207 0.2677 0.5654
0.0123 1 1
0.0367 0.3689 1
0.0893 0.3571 1
0.032 0.2916 0.8352
0.0489 0.4566 1
0.0683 0.3817 1
0.0616 0.2546 1
0.0882 0.3528 1
0.0123 0.4093 1
0.0953 0.2968 1
0.0229 0.2631 1
0.1035 0.7289 0.7945
0.0314 0.3346 0.5566
0.1031 0.6781 0.9274
0.0742 0.3104 1
0.0107 0.4816 1
0.0921 0.3522 1
0.0367 0.4431 1
0.0742 0.2892 1
0.0668 0.3442 1
0.2194 0.9174 1
0.1305 0.6921 1
0.0753 0.2619 1
0.0333 0.5828 0.7552
0.0103 0.2954 0.2935
0.3249 0.5389 1
0.0768 0.3095 1
0.3181 0.8943 1
0.0905 0.3566 1
0.0219 0.7226 0.7226
0.1004 0.3907 0.7662
0.1031 0.7281 0.8397
0.0498 0.6192 1
0.0103 0.3444 0.6774
0.0273 0.2824 1
0.1836 0.8161 1
0.0102 0.3293 0.2935
0.025 0.281 1
0.1732 0.8851 1
0.0123 0.5913 1
0.2234 0.921 1
0.0249 0.2536 1
0.0879 0.37 1
0.0103 0.294 1
0.0099 0.5046 1
0.0112 0.3144 1
0.0236 0.2835 0.6925
0.0917 0.3668 1
0.0099 0.3006 0.5415
0.0491 0.6131 1
0.0273 0.3505 1
0.0637 0.2554 1
0.1324 0.3288 1
0.2012 0.494 0.9397
0.3286 0.4951 1
0.0121 0.2505 1
0.0115 0.3842 0.554
0.2427 0.9264 1
0.2417 0.9268 1
0.0123 0.294 1
0.0123 0.5582 1
0.0219 0.2635 1
0.0419 0.4461 0.779
0.0498 0.3404 1
0.0111 0.2881 1
0.1469 0.8533 1
0.0963 0.3525 1
0.1019 0.7334 0.8456
0.0123 0.2805 1
0.0105 0.2641 1
0.1371 0.7076 1
0.0106 0.5512 1
0.1743 0.7835 1
0.0712 0.4828 1
0.1609 0.8232 1
0.044 0.2936 1
0.0675 0.4431 1
0.0458 0.275 1
0.0851 0.283 1
0.0121 0.3518 0.5596
0.3927 0.4858 1
0.0668 0.6774 1
0.099 0.5766 0.5762
0.0107 0.3418 0.2935
0.0102 0.2954 0.2935
0.0126 0.3563 0.5
0.1387 0.7868 0.8854
0.1015 0.7323 0.964
0.0882 0.3521 1
0.012 0.2597 1
0.0574 0.4056 1
0.0226 0.2711 1
0.187 0.8482 1
0.0707 0.2707 1
0.0533 0.2504 1
0.0921 0.2844 1
0.0123 0.6368 1
0.0102 1 1
0.0123 0.3183 1
0.0738 0.4576 1
0.0102 0.3159 1
0.111 0.6776 0.6631
0.2416 0.3203 1
0.0219 0.3208 1
0.0905 0.3568 1
0.1019 0.7282 0.9033
0.0921 0.2832 1
0.0921 0.3521 1
0.0144 0.7557 0.5
0.015 0.8001 1
0.2323 0.5777 1
0.2166 0.2876 1
0.0921 0.3521 1
0.0237 0.2598 1
0.0433 1 1
0.0123 0.5986 1
0.0096 0.3842 0.554
0.0362 0.3055 1
0.0921 0.3522 1
0.0623 0.8191 1
0.0219 0.6206 1
0.0634 0.263 1
0.0098 1 1
0.2595 0.613 1
0.0966 0.2891 1
0.0123 0.6015 1
0.0451 0.663 1
0.0115 0.3685 1
0.074 0.3821 1
0.0227 0.3207 1
0.2284 0.45 1
0.1908 0.5894 1
0.0117 0.3737 1
0.3331 0.4358 1
0.0951 0.337 1

Assayability

Assay information

  • Assay for Glucose-6-Phosphate Dehydrogenase pH 9 (1.1.1.49 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.
  • BRENDA Assay
  • An enzyme with this EC number or name or sequence has been assayed in Plasmodium falciparum ( 1 )

Reagent availability

  • Pyoe003883AAB;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Pyoe003883; Recombinant protein: truncated; Source: P yoelii; 6-phosphogluconolactonase ; Identifier: PY00793
  • Reagent:
  • Target Type Source Notes
    PF3D7_1453800 cloned gene BRENDA A gene with this EC number or name or sequence has been cloned from Plasmodium falciparum ( 1 )

Bibliographic References

176 literature references were collected for this gene.

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User comments

2009-06-29 16:00:17 user Greg Crowther added PDB code for this protein is wrong

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Gene identifier PF3D7_1453800 (Plasmodium falciparum), glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
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