pI: 6.0575 |
Length (AA): 957 |
MW (Da): 106041 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 954 | 4ady (A) | 9 | 914 | 15.00 | 0 | 1 | 0.97062 | 0.34 |
105 | 584 | 4ady (A) | 109 | 574 | 24.00 | 0 | 1 | 0.652767 | 0.4 |
443 | 573 | 2n3t (A) | 483 | 612 | 35.00 | 0 | 0.86 | 0.490986 | 0.53 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127950)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G20580 | 26S proteasome regulatory subunit S2 1A |
Arabidopsis thaliana | AT4G28470 | 26S proteasome non-ATPase regulatory subunit 2 1B |
Babesia bovis | BBOV_IV009920 | proteasome 26S regulatory subunit, putative |
Brugia malayi | Bm1_30845 | 26S proteasome regulatory complex subunit p97 |
Candida albicans | CaO19.12421 | similar to S. cerevisiae RPN1 (YHR027C) subunit of the 19S regulatory particle of the 26S proteasome |
Candida albicans | CaO19.4956 | similar to S. cerevisiae RPN1 (YHR027C) subunit of the 19S regulatory particle of the 26S proteasome |
Caenorhabditis elegans | CELE_T22D1.9 | Protein RPN-1 |
Cryptosporidium hominis | Chro.80073 | 26S proteasome regulatory subunit S2 (RPN1) |
Cryptosporidium parvum | cgd8_570 | proteasome regulatory subunit S2 (RPN1) |
Dictyostelium discoideum | DDB_G0293752 | 26S proteasome non-ATPase regulatory subunit 2 |
Drosophila melanogaster | Dmel_CG7762 | Regulatory particle non-ATPase 1 |
Echinococcus granulosus | EgrG_000223600 | 26s proteasome regulatory particle subunit |
Entamoeba histolytica | EHI_198010 | 19S cap proteasome S2 subunit |
Echinococcus multilocularis | EmuJ_000223600 | 26s proteasome regulatory particle subunit |
Giardia lamblia | GL50803_33166 | 26S proteasome non-ATPase regulatory subunit 2 |
Homo sapiens | ENSG00000175166 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 |
Leishmania braziliensis | LbrM.29.0130 | proteasome regulatory non-ATPase subunit, putative |
Leishmania donovani | LdBPK_290120.1 | proteasome regulatory non-ATPase subunit, putative |
Leishmania infantum | LinJ.29.0120 | proteasome regulatory non-ATPase subunit, putative |
Leishmania major | LmjF.29.0120 | proteasome regulatory non-ATPase subunit, putative |
Leishmania mexicana | LmxM.08_29.0120 | proteasome regulatory non-ATPase subunit, putative |
Loa Loa (eye worm) | LOAG_02608 | 26S proteasome regulatory complex subunit p97 |
Mus musculus | ENSMUSG00000006998 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 |
Neospora caninum | NCLIV_056700 | 26S proteasome regulatory subunit rpn1, related |
Oryza sativa | 4346741 | Os09g0326800 |
Oryza sativa | 4328287 | Os02g0146700 |
Plasmodium berghei | PBANKA_0303600 | 26S proteasome regulatory subunit RPN1, putative |
Plasmodium falciparum | PF3D7_0205900 | 26S proteasome regulatory subunit RPN1, putative |
Plasmodium knowlesi | PKNH_0415000 | 26S proteasome regulatory subunit RPN1, putative |
Plasmodium vivax | PVX_003730 | 26S proteasome regulatory subunit RPN1, putative |
Plasmodium yoelii | PY01123 | Proteasome/cyclosome repeat, putative |
Saccharomyces cerevisiae | YHR027C | proteasome regulatory particle base subunit RPN1 |
Schistosoma japonicum | Sjp_0076480 | ko:K03028 26S proteasome regulatory subunit N1, putative |
Schistosoma mansoni | Smp_000030.3 | 26s proteasome regulatory particle subunit |
Schistosoma mansoni | Smp_000030.1 | 26s proteasome regulatory particle subunit |
Schistosoma mansoni | Smp_000030.2 | 26s proteasome regulatory particle subunit |
Schmidtea mediterranea | mk4.005486.05 | 26S proteasome non-ATPase regulatory subunit 2 |
Schmidtea mediterranea | mk4.008626.01 | 26S proteasome non-ATPase regulatory subunit 2 |
Schmidtea mediterranea | mk4.000133.00 | 26S proteasome non-ATPase regulatory subunit 2 |
Schmidtea mediterranea | mk4.005537.01 | 26S proteasome non-ATPase regulatory subunit 2 |
Schmidtea mediterranea | mk4.011959.00 | 26S proteasome non-ATPase regulatory subunit 2 |
Schmidtea mediterranea | mk4.004253.03 | 26S proteasome non-ATPase regulatory subunit 2 |
Schmidtea mediterranea | mk4.007990.01 | |
Schmidtea mediterranea | mk4.001339.01 | 26S proteasome non-ATPase regulatory subunit 2 |
Schmidtea mediterranea | mk4.011440.00 | |
Schmidtea mediterranea | mk4.014019.01 | 26S proteasome non-ATPase regulatory subunit 2 |
Trypanosoma brucei gambiense | Tbg972.3.6220 | 26S proteasome regulatory non-ATPase subunit |
Trypanosoma brucei | Tb927.3.5520 | 26S proteasome regulatory non-ATPase subunit |
Trypanosoma congolense | TcIL3000_3_3470 | 26S proteasome regulatory non-ATPase subunit |
Trypanosoma cruzi | TcCLB.508409.9 | 26S proteasome regulatory non-ATPase subunit, putative |
Trypanosoma cruzi | TcCLB.504221.20 | 26S proteasome regulatory non-ATPase subunit, putative |
Toxoplasma gondii | TGME49_313410 | proteasome 26S regulatory subunit |
Theileria parva | TP01_0709 | 26S proteasome regulatory subunit 2, putative |
Trichomonas vaginalis | TVAG_286380 | 26S proteasome regulatory subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.5520 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.5520 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.5520 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.3.5520 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T22D1.9 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T22D1.9 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T22D1.9 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T22D1.9 | Caenorhabditis elegans | sterile | wormbase |
YHR027C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0303600 | Plasmodium berghei | Slow | plasmo |
TGME49_313410 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | Compounds | References |