pI: 8.6879 |
Length (AA): 326 |
MW (Da): 36186 |
Paralog Number:
8
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
7 | 323 | 3rd5 (A) | 2 | 286 | 37.00 | 0 | 1 | 1.16799 | -0.1 |
15 | 49 | 1uzn (B) | 10 | 44 | 37.00 | 0 | 0.29 | 0.508462 | -0.35 |
17 | 73 | 1iy8 (A) | 10 | 66 | 26.00 | 0 | 0.52 | 0.575947 | -1.22 |
18 | 62 | 3tzq (B) | 5 | 49 | 44.00 | 0 | 0.85 | 0.719137 | -0.89 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126621)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G53100 | Rossmann-fold NAD(P)-binding domain-containing protein |
Arabidopsis thaliana | AT4G11410 | Rossmann-fold NAD(P)-binding domain-containing protein |
Arabidopsis thaliana | AT4G23420 | NAD(P)-binding Rossmann-fold superfamily protein |
Arabidopsis thaliana | AT4G23430 | short-chain dehydrogenase TIC 32 |
Arabidopsis thaliana | AT1G64590 | NAD(P)-binding Rossmann-fold superfamily protein |
Arabidopsis thaliana | AT2G37540 | Rossmann-fold NAD(P)-binding domain-containing protein |
Arabidopsis thaliana | AT5G02540 | NAD(P)-binding Rossmann-fold superfamily protein |
Babesia bovis | BBOV_III007020 | conserved hypothetical protein |
Brugia malayi | Bm1_24195 | oxidoreductase, short chain dehydrogenase/reductase family protein |
Brugia malayi | Bm1_51270 | oxidoreductase, short chain dehydrogenase/reductase family protein |
Candida albicans | CaO19.7952 | related to S. pombe short chain dehydrogenase |
Candida albicans | CaO19.320 | related to S. pombe short chain dehydrogenase |
Candida albicans | CaO19.10860 | potential short chain dehydrogenase similar to S. cerevisiae YOR246C |
Candida albicans | CaO19.4521 | similar to S. cerevisiae YOR246C |
Candida albicans | CaO19.11996 | similar to S. cerevisiae YOR246C |
Candida albicans | CaO19.3352 | C terminal truncated version of allele CaP19.10860, similar to S. cerevisiae YOR246C |
Caenorhabditis elegans | CELE_C15H11.4 | Protein DHS-22 |
Cryptosporidium hominis | Chro.40258 | ENSANGP00000010899 |
Cryptosporidium parvum | cgd4_2270 | oxidoreductase, short-chain dehydrogenase family, putative |
Dictyostelium discoideum | DDB_G0295833 | short-chain dehydrogenase/reductase family protein |
Dictyostelium discoideum | DDB_G0293604 | short-chain dehydrogenase/reductase family protein |
Dictyostelium discoideum | DDB_G0273855 | short-chain dehydrogenase/reductase family protein |
Dictyostelium discoideum | DDB_G0288917 | hypothetical protein |
Dictyostelium discoideum | DDB_G0284919 | hypothetical protein |
Drosophila melanogaster | Dmel_CG2065 | CG2065 gene product from transcript CG2065-RB |
Drosophila melanogaster | Dmel_CG30495 | CG30495 gene product from transcript CG30495-RB |
Drosophila melanogaster | Dmel_CG2064 | CG2064 gene product from transcript CG2064-RA |
Drosophila melanogaster | Dmel_CG2070 | CG2070 gene product from transcript CG2070-RB |
Drosophila melanogaster | Dmel_CG30491 | CG30491 gene product from transcript CG30491-RA |
Drosophila melanogaster | Dmel_CG3842 | CG3842 gene product from transcript CG3842-RD |
Echinococcus granulosus | EgrG_000422100 | retinol dehydrogenase 11 |
Echinococcus granulosus | EgrG_000079200 | retinol dehydrogenase 11 |
Entamoeba histolytica | EHI_179310 | short chain dehydrogenase family protein |
Entamoeba histolytica | EHI_158310 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000422100 | retinol dehydrogenase 11 |
Echinococcus multilocularis | EmuJ_000079200 | retinol dehydrogenase 11 |
Homo sapiens | ENSG00000072042 | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) |
Homo sapiens | ENSG00000240857 | retinol dehydrogenase 14 (all-trans/9-cis/11-cis) |
Homo sapiens | ENSG00000160439 | retinol dehydrogenase 13 (all-trans/9-cis) |
Homo sapiens | ENSG00000139988 | retinol dehydrogenase 12 (all-trans/9-cis/11-cis) |
Leishmania braziliensis | LbrM.10.0090 | dehydrogenase-like protein |
Leishmania braziliensis | LbrM.34.2080 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_100070.1 | dehydrogenase-like protein |
Leishmania donovani | LdBPK_352190.1 | short chain dehydrogenase, putative |
Leishmania infantum | LinJ.10.0070 | dehydrogenase-like protein |
Leishmania infantum | LinJ.35.2190 | hypothetical protein, conserved |
Leishmania major | LmjF.10.0090 | dehydrogenase-like protein |
Leishmania major | LmjF.35.2150 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.34.2150 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.10.0090 | dehydrogenase-like protein |
Loa Loa (eye worm) | LOAG_10783 | oxidoreductase |
Loa Loa (eye worm) | LOAG_06968 | oxidoreductase |
Mycobacterium leprae | ML0315c | Probable oxidoreductase |
Mus musculus | ENSMUSG00000066441 | retinol dehydrogenase 11 |
Mus musculus | ENSMUSG00000020621 | retinol dehydrogenase 14 (all-trans and 9-cis) |
Mus musculus | ENSMUSG00000008435 | retinol dehydrogenase 13 (all-trans and 9-cis) |
Mus musculus | ENSMUSG00000021123 | retinol dehydrogenase 12 |
Mycobacterium tuberculosis | Rv0439c | Probable dehydrogenase/reductase |
Mycobacterium tuberculosis | Rv0068 | Probable oxidoreductase |
Mycobacterium tuberculosis | Rv2263 | Possible oxidoreductase |
Mycobacterium ulcerans | MUL_1391 | short chain dehydrogenase |
Mycobacterium ulcerans | MUL_1288 | short chain dehydrogenase |
Mycobacterium ulcerans | MUL_3862 | short chain dehydrogenase |
Neospora caninum | NCLIV_026580 | hypothetical protein |
Oryza sativa | 9269206 | Os10g0547950 |
Oryza sativa | 4349944 | Os11g0181700 |
Oryza sativa | 4347912 | Os09g0570300 |
Oryza sativa | 4349945 | Os11g0181800 |
Oryza sativa | 4349296 | Os10g0548000 |
Oryza sativa | 4324493 | Os01g0151700 |
Onchocerca volvulus | OVOC6946 | Dehydrogenase\/reductase SDR family member 13 homolog |
Onchocerca volvulus | OVOC7285 | Dehydrogenase\/reductase SDR family member 13 homolog |
Plasmodium berghei | PBANKA_1124900 | oxidoreductase, putative |
Plasmodium falciparum | PF3D7_0626100 | oxidoreductase, short-chain dehydrogenase family, putative |
Plasmodium knowlesi | PKNH_1123700 | putative oxidoreductase, short-chain dehydrogenase family, putative |
Saccharomyces cerevisiae | YOR246C | Env9p |
Schistosoma japonicum | Sjp_0088470 | WW domain-containing oxidoreductase, putative |
Schistosoma japonicum | Sjp_0132490 | Retinol dehydrogenase 12, putative |
Schistosoma japonicum | Sjp_0115480 | expressed protein |
Schistosoma japonicum | Sjp_0203960 | ko:K00100 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) [EC:1.1.1.-], putative |
Schistosoma japonicum | Sjp_0214400 | IPR002347,Glucose/ribitol dehydrogenase,domain-containing |
Schistosoma japonicum | Sjp_0218500 | ko:K00100 retinol dehydrogenase 11 [EC:1.1.1.-], putative |
Schistosoma japonicum | Sjp_0036830 | Retinol dehydrogenase 11, putative |
Schistosoma japonicum | Sjp_0078270 | IPR002347,Glucose/ribitol dehydrogenase,domain-containing |
Schistosoma japonicum | Sjp_0036820 | Retinol dehydrogenase 12, putative |
Schistosoma japonicum | Sjp_0083640 | ko:K00100 retinol dehydrogenase [EC:1.1.1.-], putative |
Schistosoma mansoni | Smp_139680 | short chain dehydrogenase |
Schistosoma mansoni | Smp_032370 | short chain dehydrogenase |
Schistosoma mansoni | Smp_139700 | retinal dehydrogenase |
Schistosoma mansoni | Smp_101730 | short chain dehydrogenase |
Schistosoma mansoni | Smp_081430 | short chain dehydrogenase |
Schistosoma mansoni | Smp_179830 | short chain dehydrogenase |
Schistosoma mansoni | Smp_120070 | short chain dehydrogenase |
Schistosoma mansoni | Smp_139690 | short chain dehydrogenase |
Schistosoma mansoni | Smp_076580 | short chain dehydrogenase |
Schmidtea mediterranea | mk4.011384.00 | |
Schmidtea mediterranea | mk4.007652.02 | |
Schmidtea mediterranea | mk4.004574.00 | Retinol dehydrogenase 13 |
Schmidtea mediterranea | mk4.023979.00 | |
Schmidtea mediterranea | mk4.006860.02 | |
Schmidtea mediterranea | mk4.003801.04 | |
Schmidtea mediterranea | mk4.010707.00 | Retinol dehydrogenase 13 |
Trypanosoma brucei gambiense | Tbg972.9.8780 | short-chain dehydrogenase, putative |
Trypanosoma brucei | Tb927.9.14070 | short-chain dehydrogenase, putative |
Trypanosoma congolense | TcIL3000_9_6000 | short-chain dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.510759.10 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.510763.30 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_260460 | oxidoreductase, putative |
Theileria parva | TP04_0605 | oxidoreductase, putative |
Theileria parva | TP04_0606 | oxidoreductase, putative |
Trichomonas vaginalis | TVAG_281110 | short-chain dehydrogenases/reductase, putative |
Trichomonas vaginalis | TVAG_281120 | short-chain dehydrogenase, putative |
Trichomonas vaginalis | TVAG_262850 | short-chain dehydrogenases/reductase, putative |
Trichomonas vaginalis | TVAG_281090 | short-chain dehydrogenase, putative |
Trichomonas vaginalis | TVAG_262820 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_262830 | hydroxyacyl dehydrogenase, putative |
Trichomonas vaginalis | TVAG_262900 | short-chain dehydrogenase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu68 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu442 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu2298 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb09.211.4600 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.211.4600 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.211.4600 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb09.211.4600 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1124900 | Plasmodium berghei | Slow | plasmo |
TGME49_260460 | Toxoplasma gondii | Probably non-essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Macaca mulatta | Hydroxysteroid 11-beta dehydrogenase 1 | 140 aa | 25.6% | 164 aa | Compounds | References |
Cochliobolus lunatus | 17-beta-hydroxysteroid-dehydrogenase | 270 aa | 26.1% | 238 aa | Compounds | References |