Detailed view for Smp_163820

Basic information

TDR Targets ID: 284454
Schistosoma mansoni, phospholipid-transporting atpase
Source Database / ID:  GeneDB

pI: 7.0871 | Length (AA): 1311 | MW (Da): 148513 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00122   E1-E2 ATPase
PF13246   Cation transport ATPase (P-type)
PF16209   Phospholipid-translocating ATPase N-terminal
PF16212   Phospholipid-translocating P-type ATPase C-terminal

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0016020   membrane  
GO:0005524   ATP binding  
GO:0004012   phospholipid-translocating ATPase activity  
GO:0000287   magnesium ion binding  
GO:0000166   nucleotide binding  
GO:0015914   phospholipid transport  
GO:0006754   ATP biosynthetic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
84 921 2zxe (A) 117 740 28.00 0.0025 1 0.457807 1.54
753 794 4bbj (A) 551 592 38.00 0.6 0.64 0.482637 -0.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126610)

Species Accession Gene Product
Arabidopsis thaliana AT5G04930   phospholipid-transporting ATPase 1
Arabidopsis thaliana AT1G59820   phospholipid-transporting ATPase 3
Arabidopsis thaliana AT1G17500   ATPase E1-E2 type family protein / haloacid dehalogenase-like hydrolase family protein
Arabidopsis thaliana AT1G72700   putative phospholipid-transporting ATPase 5
Arabidopsis thaliana AT3G27870   putative phospholipid-transporting ATPase 8
Arabidopsis thaliana AT3G13900   putative phospholipid-transporting ATPase 7
Arabidopsis thaliana AT1G13210   autoinhibited Ca2+/ATPase II
Arabidopsis thaliana AT1G68710   putative phospholipid-transporting ATPase 9
Arabidopsis thaliana AT3G25610   ATPase E1-E2 type family protein / haloacid dehalogenase-like hydrolase family protein
Arabidopsis thaliana AT1G54280   ATPase E1-E2 type family protein / haloacid dehalogenase-like hydrolase family protein
Arabidopsis thaliana AT1G26130   putative phospholipid-transporting ATPase 12
Babesia bovis BBOV_IV001830   phospholipid-translocating P-type ATPase
Brugia malayi Bm1_41570   phospholipid-translocating P-type ATPase, flippase family protein
Candida albicans CaO19.2226   hypothetical protein
Candida albicans CaO19.7955   ATPase / transporter
Candida albicans CaO19.8547   similar to potential aminophospholipid translocase ATPase involved in intracellular protein transport
Candida albicans CaO19.932   similar to potential aminophospholipid translocase ATPase involved in intracellular protein transport
Candida albicans CaO19.6778   Membrane-spanning Ca-ATPase (P-type)
Candida albicans CaO19.323   ATPase / transporter
Candida albicans CaO19.14070   Membrane-spanning Ca-ATPase (P-type)
Caenorhabditis elegans CELE_H06H21.10   Protein TAT-2, isoform A
Caenorhabditis elegans CELE_Y49E10.11   Protein TAT-1, isoform B
Cryptosporidium hominis Chro.30311   ATPase, aminophospholipid transporter-like, class I, type 8A, member 2; ATPase, class 1, member a; ATPase 8A2, p type; ATPase 8A
Cryptosporidium parvum cgd3_2730   protein with 10 transmembrane domains, possible calcium transporting ATpase or aminophospholipid transporter
Cryptosporidium parvum cgd7_1760   P-type ATpase (calcium/phospholipid-transporter), 9 transmembrane domains
Dictyostelium discoideum DDB_G0275871   phospholipid-translocating P-type ATPase family protein
Dictyostelium discoideum DDB_G0269380   P-type ATPase
Dictyostelium discoideum DDB_G0275535   phospholipid-translocating P-type ATPase family protein
Dictyostelium discoideum DDB_G0281401   P-type ATPase
Dictyostelium discoideum DDB_G0276541   P-type ATPase
Dictyostelium discoideum DDB_G0276375   phospholipid-translocating P-type ATPase family protein
Dictyostelium discoideum DDB_G0286891   P-type ATPase
Drosophila melanogaster Dmel_CG9981   CG9981 gene product from transcript CG9981-RC
Drosophila melanogaster Dmel_CG42321   CG42321 gene product from transcript CG42321-RM
Drosophila melanogaster Dmel_CG14741   CG14741 gene product from transcript CG14741-RF
Echinococcus granulosus EgrG_000079100   phospholipid transporting ATPase IF
Echinococcus granulosus EgrG_000531500   phospholipid translocating ATPase
Echinococcus granulosus EgrG_001082000   phospholipid transporting ATPase IA
Echinococcus granulosus EgrG_000079000   phospholipid transporting atpase ih
Entamoeba histolytica EHI_096620   phospholipid-transporting P-type ATPase, putative
Entamoeba histolytica EHI_188210   phospholipid-transporting P-type ATPase, putative
Entamoeba histolytica EHI_141350   phospholipid-transporting ATPase IA, putative
Entamoeba histolytica EHI_174280   phospholipid-translocating P-type ATPase, putative
Entamoeba histolytica EHI_024120   phospholipid-transporting P-type ATPase, putative
Entamoeba histolytica EHI_135220   phospholipid-transporting P-type ATPase, putative
Echinococcus multilocularis EmuJ_000079100   phospholipid transporting ATPase IF
Echinococcus multilocularis EmuJ_000531500   phospholipid translocating ATPase
Echinococcus multilocularis EmuJ_000079000   phospholipid transporting atpase ih phospholipid transporting atpase if
Echinococcus multilocularis EmuJ_001082000   phospholipid transporting ATPase IA
Homo sapiens ENSG00000124406   ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
Homo sapiens ENSG00000081923   ATPase, aminophospholipid transporter, class I, type 8B, member 1
Homo sapiens ENSG00000130270   ATPase, aminophospholipid transporter, class I, type 8B, member 3
Homo sapiens ENSG00000143515   ATPase, aminophospholipid transporter, class I, type 8B, member 2
Homo sapiens ENSG00000132932   ATPase, aminophospholipid transporter, class I, type 8A, member 2
Homo sapiens ENSG00000101974   ATPase, class VI, type 11C
Homo sapiens ENSG00000058063   ATPase, class VI, type 11B
Homo sapiens ENSG00000104043   ATPase, class I, type 8B, member 4
Homo sapiens ENSG00000068650   ATPase, class VI, type 11A
Leishmania braziliensis LbrM.13.1400   phospholipid-transporting ATPase 1-like protein
Leishmania braziliensis LbrM.13.1380   phospholipid-transporting ATPase 1-like protein
Leishmania donovani LdBPK_131590.1   Miltefosine transporter
Leishmania infantum LinJ.13.1590   phospholipid-transporting ATPase 1-like protein
Leishmania major LmjF.13.1530   phospholipid-transporting ATPase 1-like protein
Leishmania mexicana LmxM.13.1530   phospholipid-transporting ATPase 1-like protein
Loa Loa (eye worm) LOAG_05914   hypothetical protein
Loa Loa (eye worm) LOAG_12432   phospholipid-transporting ATPase ID
Loa Loa (eye worm) LOAG_01608   hypothetical protein
Loa Loa (eye worm) LOAG_02665   hypothetical protein
Loa Loa (eye worm) LOAG_01717   hypothetical protein
Mus musculus ENSMUSG00000028457   ATPase, class I, type 8B, member 5
Mus musculus ENSMUSG00000003341   ATPase, class I, type 8B, member 3
Mus musculus ENSMUSG00000060671   ATPase, class I, type 8B, member 2
Mus musculus ENSMUSG00000037685   ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
Mus musculus ENSMUSG00000031441   ATPase, class VI, type 11A
Mus musculus ENSMUSG00000060131   ATPase, class I, type 8B, member 4
Mus musculus ENSMUSG00000039529   ATPase, class I, type 8B, member 1
Mus musculus ENSMUSG00000021983   ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Mus musculus ENSMUSG00000037400   ATPase, class VI, type 11B
Mus musculus ENSMUSG00000062949   ATPase, class VI, type 11C
Neospora caninum NCLIV_063910   hypothetical protein
Oryza sativa 4337521   Os05g0100600
Oryza sativa 4348609   Os10g0412000
Oryza sativa 4341328   Os06g0565900
Oryza sativa 4332710   Os03g0326200
Oryza sativa 4324268   Os01g0277600
Oryza sativa 4332752   Os03g0334700
Onchocerca volvulus OVOC197  
Plasmodium berghei PBANKA_1434800   aminophospholipid-transporting P-ATPase, putative
Plasmodium falciparum PF3D7_1219600   aminophospholipid-transporting P-ATPase
Plasmodium knowlesi PKNH_1438800   aminophospholipid-transporting P-ATPase, putative
Plasmodium vivax PVX_123625   aminophospholipid-transporting P-ATPase, putative
Plasmodium yoelii PY01853   ATPase 2
Saccharomyces cerevisiae YER166W   aminophospholipid-translocating P4-type ATPase DNF1
Saccharomyces cerevisiae YDR093W   aminophospholipid-translocating P4-type ATPase DNF2
Saccharomyces cerevisiae YAL026C   aminophospholipid-translocating P4-type ATPase DRS2
Schistosoma japonicum Sjp_0134650   Probable phospholipid-transporting ATPase IA, putative
Schistosoma japonicum Sjp_0044180   IPR001757,ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter,domain-containing
Schistosoma japonicum Sjp_0029000   Probable phospholipid-transporting ATPase IA, putative
Schistosoma japonicum Sjp_0046490   ko:K01530 phospholipid-translocating ATPase [EC3.6.3.1], putative
Schistosoma japonicum Sjp_0044170   ko:K01530 phospholipid-translocating ATPase [EC3.6.3.1], putative
Schistosoma mansoni Smp_163820   phospholipid-transporting atpase
Schistosoma mansoni Smp_104500   phospholipid-transporting atpase
Schmidtea mediterranea mk4.001610.06   Phospholipid-transporting atpase
Schmidtea mediterranea mk4.000005.35  
Schmidtea mediterranea mk4.002342.00   Atpase, class VI, type 11c, putative
Schmidtea mediterranea mk4.013443.00  
Schmidtea mediterranea mk4.000210.04  
Schmidtea mediterranea mk4.000654.04   Probable phospholipid-transporting ATPase IK
Schmidtea mediterranea mk4.000210.02   Probable phospholipid-transporting ATPase IK
Schmidtea mediterranea mk4.000210.03  
Schmidtea mediterranea mk4.001610.07   Phospholipid-transporting ATPase tat-1
Schmidtea mediterranea mk4.002393.01   Phospholipid-transporting atpase
Schmidtea mediterranea mk4.000654.03  
Schmidtea mediterranea mk4.001815.02  
Schmidtea mediterranea mk4.019171.00  
Schmidtea mediterranea mk4.032078.00  
Schmidtea mediterranea mk4.000210.05  
Trypanosoma brucei gambiense Tbg972.11.3780   phospholipid-transporting ATPase 1-like protein, putative
Trypanosoma brucei Tb927.11.3350   phospholipid-transporting ATPase 1-like protein, putative
Trypanosoma congolense TcIL3000.11.3220   phospholipid-transporting ATPase 1-like protein, putative
Trypanosoma cruzi TcCLB.509591.60   phospholipid-transporting ATPase 1-like protein, putative
Trypanosoma cruzi TcCLB.503999.100   phospholipid-transporting ATPase 1-like protein, putative
Toxoplasma gondii TGME49_247690   phospholipid-translocating P-type ATPase, flippase subfamily protein
Theileria parva TP03_0479   P-type ATPase, putative
Trichomonas vaginalis TVAG_138560   phospholipid-transporting ATPase, putative
Trichomonas vaginalis TVAG_383260   cation-transporting ATPase, putative
Trichomonas vaginalis TVAG_213610   ATPase, class I, type 8B, putative
Trichomonas vaginalis TVAG_499250   phospholipid-transporting ATPase, putative
Trichomonas vaginalis TVAG_093660   phospholipid-transporting ATPase, putative
Trichomonas vaginalis TVAG_281540   ATPase, class VI, type 11C, putative
Trichomonas vaginalis TVAG_056000   ATPase, class VI, type 11C, putative

Essentiality

Smp_163820 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.0850 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.0850 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.0850 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb11.02.0850 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y49E10.11 Caenorhabditis elegans embryonic lethal wormbase
PBANKA_1434800 Plasmodium berghei Essential plasmo
TGME49_247690 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_163820 (Schistosoma mansoni), phospholipid-transporting atpase
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