Detailed view for Smp_163430

Basic information

TDR Targets ID: 284543
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 7.422 | Length (AA): 438 | MW (Da): 49090 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12171   Zinc-finger double-stranded RNA-binding
PF12756   C2H2 type zinc-finger (2 copies)

Gene Ontology

Mouse over links to read term descriptions.
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
118 147 2mkd (A) 183 212 20.00 0 0.21 0.265793 0.05
121 171 2iyk (A) 26 71 41.00 0.8 0.56 0.381838 0.93

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127615)

Species Accession Gene Product
Arabidopsis thaliana AT2G24500   zinc finger domain protein REI1-LIKE 2
Arabidopsis thaliana AT4G31420   protein REI1-LIKE 1
Babesia bovis BBOV_III010450   hypothetical protein
Brugia malayi Bm1_41325   Zinc finger, C2H2 type family protein
Candida albicans CaO19.59   potential Zn finger orf similar to S. cerevisiae YBR267W
Candida albicans CaO19.7720   potential Zn finger orf similar to S. cerevisiae YBR267W
Candida albicans CaO19.6407   potential zinc finger protein similar to S. cerevisiae YLR387C
Candida albicans CaO19.13765   potential zinc finger protein similar to S. cerevisiae YLR387C
Caenorhabditis elegans CELE_C16A3.4   Protein C16A3.4
Cryptosporidium hominis Chro.80183   hypothetical protein
Cryptosporidium parvum cgd8_1550   S. cerevisiae YLR387c-like protein with 2x C2H2 like zinc fingers conserved across eukaryotes plus an apicomplexan-specific glob
Dictyostelium discoideum DDB_G0290029   C2H2-type zinc finger-containing protein
Drosophila melanogaster Dmel_CG6769   CG6769 gene product from transcript CG6769-RB
Echinococcus granulosus EgrG_000377550   zinc finger protein 622
Entamoeba histolytica EHI_154230   zinc finger protein 622, putative
Echinococcus multilocularis EmuJ_000377550   zinc finger protein 622
Giardia lamblia GL50803_13007   Zinc finger domain
Homo sapiens ENSG00000173545   zinc finger protein 622
Leishmania braziliensis LbrM.30.2200   zinc-finger protein, conserved
Leishmania donovani LdBPK_302260.1   zinc-finger protein, conserved
Leishmania infantum LinJ.30.2260   zinc-finger protein, conserved
Leishmania major LmjF.30.2250   zinc-finger protein, conserved
Leishmania mexicana LmxM.29.2250   zinc-finger protein, conserved
Loa Loa (eye worm) LOAG_08093   hypothetical protein
Loa Loa (eye worm) LOAG_09469   zinc finger protein
Mus musculus ENSMUSG00000052253   zinc finger protein 622
Neospora caninum NCLIV_068940   hypothetical protein
Oryza sativa 4341920   Os06g0693500
Onchocerca volvulus OVOC8723   Zinc finger protein 622 homolog
Plasmodium berghei PBANKA_1007400   zinc finger protein, putative
Plasmodium falciparum PF3D7_0409800   zinc finger protein, putative
Plasmodium knowlesi PKNH_0307900   zinc finger protein, putative
Plasmodium vivax PVX_000755   zinc finger protein, putative
Plasmodium yoelii PY04088   hypothetical protein
Saccharomyces cerevisiae YLR387C   Reh1p
Saccharomyces cerevisiae YBR267W   Rei1p
Schistosoma japonicum Sjp_0103440   Zinc finger protein 622, putative
Schistosoma mansoni Smp_163430   hypothetical protein
Schmidtea mediterranea mk4.009222.01  
Trypanosoma brucei gambiense Tbg972.6.3300   zinc-finger protein, conserved
Trypanosoma brucei Tb927.6.3540   zinc-finger protein, conserved
Trypanosoma congolense TcIL3000_6_3120   zinc-finger protein, conserved, putative
Trypanosoma cruzi TcCLB.506941.50   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511511.50   hypothetical protein, conserved
Toxoplasma gondii TGME49_239070   hypothetical protein
Theileria parva TP02_0101   hypothetical protein
Trichomonas vaginalis TVAG_388070   45.8 kD protein in shm1-mrpl37 intergenic region, putative

Essentiality

Smp_163430 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.3540 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.3540 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.3540 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.3540 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C16A3.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_C16A3.4 Caenorhabditis elegans slow growth wormbase
TGME49_239070 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_163430 (Schistosoma mansoni), hypothetical protein
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