pI: 7.0331 |
Length (AA): 211 |
MW (Da): 23820 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 211 | 1u3i (A) | 4 | 211 | 99.99 | 0 | 1 | 2.26558 | -1.89 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Ortholog group members (OG5_128352)
Species | Accession | Gene Product |
---|---|---|
Caenorhabditis elegans | CELE_F11G11.1 | Protein GST-8 |
Caenorhabditis elegans | CELE_R03D7.6 | Protein GST-5, isoform B |
Caenorhabditis elegans | CELE_R11G1.3 | Protein GST-11 |
Caenorhabditis elegans | CELE_F35E8.8 | Protein GST-38 |
Caenorhabditis elegans | CELE_F37B1.8 | Protein GST-19 |
Caenorhabditis elegans | CELE_K08F4.7 | Protein GST-4 |
Caenorhabditis elegans | CELE_Y53F4B.31 | Protein GST-28 |
Drosophila melanogaster | Dmel_CG8938 | Glutathione S transferase S1 |
Echinococcus granulosus | EgrG_000459050 | prostaglandin H2 D isomerase |
Echinococcus granulosus | EgrG_000685900 | glutathione S transferase |
Echinococcus multilocularis | EmuJ_000685900 | glutathione S transferase |
Echinococcus multilocularis | EmuJ_000459050 | prostaglandin H2 D isomerase |
Homo sapiens | ENSG00000163106 | hematopoietic prostaglandin D synthase |
Mus musculus | ENSMUSG00000029919 | hematopoietic prostaglandin D synthase |
Plasmodium berghei | PBANKA_1023900 | glutathione S-transferase, putative |
Plasmodium knowlesi | PKNH_1338700 | glutathione S-transferase, putative |
Plasmodium vivax | PVX_085515 | glutathione S-transferase, putative |
Plasmodium yoelii | PY05088 | glutathione s-transferase |
Schistosoma japonicum | Sjp_0063550 | ko:K01830 prostaglandin-H2 D-isomerase [EC5.3.99.2], putative |
Schistosoma mansoni | Smp_054160 | Glutathione S-transferase 28 kDa (GST 28) (GST class-mu) |
Schmidtea mediterranea | mk4.000265.20 | Glutathione S-transferase class-mu 28 kDa isozyme |
Schmidtea mediterranea | mk4.001166.03 | Glutathione S-transferase class-mu 28 kDa isozyme |
Schmidtea mediterranea | mk4.000085.08 | Glutathione S transferase-1 |
Schmidtea mediterranea | mk4.005229.02 | Glutathione S-transferase class-mu 28 kDa isozyme |
Schmidtea mediterranea | mk4.010663.01 | Glutathione S-transferase class-mu 28 kDa isozyme |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F37B1.8 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F35E8.8 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1023900 | Plasmodium berghei | Dispensable | plasmo |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | inferred from specific protein inhibition (ECO:0000020) | Schistosoma haematobium | 1581 26831 | ||
Annotator: | stewac@u.washington.edu. | Comment: | 2009/04/06. | References: | 11796588 | |
mRNA transcription (GO:0009299) | decreased (PATO:0000468) | inferred from immunological assay (ECO:0000040) | Schistosoma mansoni | 375742 378360 406919 572633 572634 572635 | ||
Annotator: | stewac@u.washington.edu. | Comment: | 2009/04/06. | References: | 10413041 | |
growth (GO:0040007) | decreased (PATO:0000468) | inferred from animal model system (ECO:0000179) | Schistosoma mansoni | 375742 378360 406919 572633 572634 572635 | ||
Annotator: | stewac@u.washington.edu. | Comment: | 2009/04/06. | References: | 3086233 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Compound | Source | Reference |
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Curated by TDRTargets | References | |
Curated by TDRTargets | References | |
Curated by TDRTargets | References | |
Curated by TDRTargets | References | |
Curated by TDRTargets | References | |
Curated by TDRTargets | References | |
Curated by TDRTargets | References | |
Curated by TDRTargets | References |
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | hematopoietic prostaglandin D synthase | Compounds | References |
Mus musculus | hematopoietic prostaglandin D synthase | Compounds | References |