Detailed view for Smp_094810

Basic information

TDR Targets ID: 284829
Schistosoma mansoni, cyclophilin E
Source Database / ID:  GeneDB

pI: 5.7734 | Length (AA): 329 | MW (Da): 36916 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00076   RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF00160   Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

Gene Ontology

Mouse over links to read term descriptions.
GO:0000413   protein peptidyl-prolyl isomerization  
GO:0003755   peptidyl-prolyl cis-trans isomerase activity  
GO:0003723   RNA binding  
GO:0003676   nucleic acid binding  
GO:0000166   nucleotide binding  
GO:0006457   protein folding  

Metabolic Pathways

Spliceosome (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 83 2cq4 (A) 129 207 19.00 0.00022 0.73 0.433843 0.29
17 110 2cqb (A) 0 90 67.00 0 1 1.10041 -0.75
27 160 4cq1 (A) 339 473 22.00 0.63 1 0.627395 -0.65
160 290 1ihg (A) 8 146 63.00 0 1 1.10288 -0.66
166 329 2cmt (A) 9 172 99.99 0 1 1.78258 -1.99

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 2CK1:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2CMT:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129285)

Species Accession Gene Product
Arabidopsis thaliana AT3G56070   rotamase cyclophilin 2
Arabidopsis thaliana AT1G13690   ATPase E1
Babesia bovis BBOV_IV004150   RNA recognition motif (RRM)-containing protein
Brugia malayi Bm1_52100   cyclophilin-type peptidyl-prolyl cis-trans isomerase-13, Bmcyp-13
Caenorhabditis elegans CELE_Y116A8C.34   Protein CYN-13, isoform B
Dictyostelium discoideum DDB_G0288291   hypothetical protein
Drosophila melanogaster Dmel_CG4886   cyclophilin-33
Echinococcus granulosus EgrG_000677200   peptidyl prolyl cis trans isomerase E
Entamoeba histolytica EHI_117870   peptidyl-prolyl cis-trans isomerase E, putative
Echinococcus multilocularis EmuJ_000677200   peptidyl prolyl cis trans isomerase E
Homo sapiens ENSG00000084072   peptidylprolyl isomerase E (cyclophilin E)
Loa Loa (eye worm) LOAG_00807   cytosolic cyclophilin
Mus musculus ENSMUSG00000028651   peptidylprolyl isomerase E (cyclophilin E)
Neospora caninum NCLIV_037600   peptidyl-prolyl cis-trans isomerase E, putative
Oryza sativa 4333394   Os03g0600400
Plasmodium berghei PBANKA_1419200   RNA-binding protein, putative
Plasmodium falciparum PF3D7_1320900   RNA-binding protein, putative
Plasmodium knowlesi PKNH_1421500   RNA-binding protein, putative
Plasmodium vivax PVX_122855   RNA-binding protein, putative
Plasmodium yoelii PY03520   peptidyl-prolyl cis-trans isomerase E-related
Schistosoma japonicum Sjp_0059010   ko:K09564 peptidyl-prolyl isomerase E (cyclophilin E), putative
Schistosoma mansoni Smp_094810   cyclophilin E
Schmidtea mediterranea mk4.000057.22   Peptidyl-prolyl cis-trans isomerase E
Toxoplasma gondii TGME49_268750   peptidyl-prolyl cis-trans isomerase E, putative
Theileria parva TP01_0340   hypothetical protein

Essentiality

Smp_094810 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y116A8C.34 Caenorhabditis elegans embryonic lethal wormbase
TGME49_268750 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 171 aa 63.2% 166 aa Compounds References
Rattus norvegicus Cyclophilin A 164 aa 64.0% 161 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_094810 (Schistosoma mansoni), cyclophilin E
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