Detailed view for Smp_175050

Basic information

TDR Targets ID: 285025
Schistosoma mansoni, factor for adipocyte differentiation
Source Database / ID:  GeneDB

pI: 6.7489 | Length (AA): 1419 | MW (Da): 157492 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00041   Fibronectin type III domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
474 582 4o00 (A) 4 103 31.00 0 0.88 0.402515 -1.08
476 568 2nzi (A) 196 277 35.00 0.13 0.58 0.275439 -0.03
478 676 5x83 (B) 840 1036 23.00 0.00046 1 0.31514 -0.06
1120 1151 4zxb (E) 869 899 61.00 0.28 0.16 0.513451 0.84

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130589)

Species Accession Gene Product
Brugia malayi Bm1_07955   Fibronectin type III domain containing protein
Drosophila melanogaster Dmel_CG42389   CG42389 gene product from transcript CG42389-RE
Echinococcus granulosus EgrG_000480400   Fibronectin type III domain containing protein
Echinococcus multilocularis EmuJ_000480400   Fibronectin type III domain containing protein
Homo sapiens ENSG00000075420   fibronectin type III domain containing 3B
Homo sapiens ENSG00000102531   fibronectin type III domain containing 3A
Loa Loa (eye worm) LOAG_06415   hypothetical protein
Mus musculus ENSMUSG00000033737   fibronectin type III domain containing 3C1
Mus musculus ENSMUSG00000039286   fibronectin type III domain containing 3B
Mus musculus ENSMUSG00000033487   fibronectin type III domain containing 3A
Mus musculus ENSMUSG00000073012   fibronectin type III domain containing 3C2
Onchocerca volvulus OVOC2462  
Schistosoma japonicum Sjp_0070940   Fibronectin type III domain-containing protein 3B, putative
Schistosoma japonicum Sjp_0105190   IPR003962,Fibronectin, type III subdomain;IPR003961,Fibronectin, type III;IPR008957,Fibronectin, type III-like fold,domain-conta
Schistosoma mansoni Smp_175050   factor for adipocyte differentiation
Schmidtea mediterranea mk4.001649.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0343 0.706 0.706
0.0104 0.8804 1
0.0085 0.3268 0.3432
0.0084 0.6788 1
0.017 0.2614 0.6652
0.0414 0.6115 0.6115
0.0461 0.2819 0.2813
0.022 0.257 0.6919
0.0111 0.334 1
0.0115 0.2557 0.2988
0.0129 0.3276 0.3276
0.0089 0.4623 0.4623
0.0275 0.301 0.301
0.0165 0.3513 0.4019
0.0471 0.341 0.3405
0.0313 0.5953 0.7027
0.037 0.706 0.706
0.0167 0.3197 0.351
0.0251 0.7407 0.7375
0.02 0.7068 0.706
0.0132 0.2972 0.7394
0.0446 0.3014 0.4674
0.0336 0.3462 0.4786
0.0216 0.706 0.706
0.0178 0.5983 0.5983
0.0446 0.3014 0.4674
0.0446 0.3014 0.4674
0.0251 0.7407 0.7375
0.0338 0.7566 0.752
0.0271 0.3613 0.7611
0.0155 0.3568 0.706
0.0116 0.6967 0.6967
0.0039 0.3299 0.3527
0.0461 0.2819 0.2813
0.0448 0.7636 0.7636
0.0334 0.4633 0.4633
0.0142 0.2992 0.3276
0.0475 0.706 0.706
0.0016 1 0.5
0.0009 0.5 0.5
0.0089 0.442 0.6887
0.0374 0.7576 0.7576
0.0216 0.3372 0.387
0.0258 0.3891 0.4414
0.0048 0.432 0.432
0.012 0.7362 0.7362
0.0272 0.706 0.706
0.0446 0.3014 0.4674
0.0312 0.5397 0
0.0083 1 0.5
0.0034 0.2581 0.2581
0.0461 0.2819 0.2813
0.0446 0.3014 0.4674
0.0223 0.4639 0.4639
0.0446 0.3014 0.4674
0.0275 0.301 0.301
0.0167 0.3197 0.351
0.0153 0.3082 0.3318
0.0084 0.6788 1
0.0178 0.5983 0.5983
0.0241 0.3619 0.413
0.0089 0.442 0.6887
0.0351 0.6072 0
0.0165 0.3513 0.4019
0.0374 0.7576 0.7576
0.0266 0.2855 0.5677
0.0446 0.3014 0.4674
0.0488 0.3798 0.3794
0.0344 0.6972 0.6972
0.0275 0.301 0.301
0.043 0.5151 0.5151
0.0403 0.706 0.706
0.0184 0.706 0.706
0.0114 0.6153 0.3459
0.0164 0.7647 0.7647
0.0261 0.2557 0.2988
0.0471 0.341 0.3405
0.0241 0.3986 0.4512
0.0275 0.301 0.301
0.0343 0.706 0.706
0.0156 0.6042 0.6042
0.0075 0.4317 0.4447
0.0255 0.706 0.706
0.0255 0.2557 0.2988
0.008 0.4641 0
0.0275 0.301 0.301
0.0378 0.586 0.586
0.0223 0.4639 0.4639
0.0261 0.3873 0.4396
0.0334 0.4633 0.4633
0.022 0.257 0.6919
0.0048 0.4176 0.4176
0.0255 0.706 0.706
0.0461 0.2819 0.2813
0.0446 0.3014 0.4674
0.0156 0.6042 0.6042
0.012 0.7362 0.7362
0.0414 0.6115 0.6115
0.0378 0.586 0.586

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_175050 (Schistosoma mansoni), factor for adipocyte differentiation
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