Detailed view for Smp_136270

Basic information

TDR Targets ID: 285246
Schistosoma mansoni, serine/threonine protein kinase
Source Database / ID:  GeneDB

pI: 4.7694 | Length (AA): 1030 | MW (Da): 119284 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF10637   Oxoglutarate and iron-dependent oxygenase degradation C-term
PF13661   2OG-Fe(II) oxygenase superfamily

Gene Ontology

Mouse over links to read term descriptions.
GO:0016705   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  
GO:0016706   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors  
GO:0005524   ATP binding  
GO:0005506   iron ion binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0031418   L-ascorbic acid binding  
GO:0006468   protein amino acid phosphorylation  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 489 3lij (A) 61 515 31.00 0 1 0.613957 0.61
1 271 3c0g (B) 30 303 30.00 0 1 0.666907 -0.88
2 274 2w4o (A) 65 328 42.00 0 1 0.614849 -0.24
401 927 4nhx (A) 25 520 37.00 0 1 0.69245 0.35

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130253)

Species Accession Gene Product
Brugia malayi Bm1_54280   hypothetical protein
Candida albicans CaO19.9368   similar to S. cerevisiae YER049W
Candida albicans CaO19.1802   similar to S. cerevisiae YER049W
Caenorhabditis elegans CELE_C17G10.1   Protein C17G10.1
Drosophila melanogaster Dmel_CG44254   CG44254 gene product from transcript CG44254-RA
Echinococcus granulosus EgrG_001121200   2 oxoglutarate and iron dependent oxygenase
Echinococcus multilocularis EmuJ_001121200   2 oxoglutarate and iron dependent oxygenase
Homo sapiens 55239   2-oxoglutarate and iron-dependent oxygenase domain containing 1
Loa Loa (eye worm) LOAG_10540   hypothetical protein
Mus musculus ENSMUSG00000033009   2-oxoglutarate and iron-dependent oxygenase domain containing 1
Onchocerca volvulus OVOC11418  
Saccharomyces cerevisiae YER049W   Tpa1p
Schistosoma japonicum Sjp_0206180   2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1, putative
Schistosoma japonicum Sjp_0088760   Calcium/calmodulin-dependent protein kinase type IV, putative
Schistosoma mansoni Smp_136270   serine/threonine protein kinase
Schmidtea mediterranea mk4.000052.19   Prolyl 3-hydroxylase OGFOD1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 24.6% 321 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 21.5% 251 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 25.4% 248 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 26.2% 244 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0092 1 1
0.0007 0.5 0.5
0.0003 0.5 0.5
0.0061 0.6883 0.6656
0.0063 0.7244 0
0.0039 0.5 0.5
0.0069 0.3067 0.3067
0.0027 1 1
0.0012 0.5 0.5
0.0032 0.5 0.5
0.0091 1 1
0.0026 0.5 0.5
0.0036 0.5 0.5
0.0022 0.5 0.5
0.0008 0.5 0.5
0.0066 0.3101 0.9479
0.0081 1 1
0.0067 0.5 0.5
0.0039 0.5 0.5
0.0042 0.5 0.5
0.0081 0.5 0.5
0.0004 0.5 0.5
0.0059 1 1
0.0039 0.9485 1
0.0033 1 1
0.0016 0.5 0.5
0.0063 1 1
0.0088 0.4477 0.6337
0.0056 1 1
0.0098 0.3242 0.2614
0.0012 0.5 0.5
0.0064 0.3377 0.9531
0.0059 1 1
0.0007 0.5 0.5
0.0012 0.5 0.5
0.0033 0.5 0.5
0.0007 0.5 0.5
0.0032 0.5 0.5
0.0059 1 1
0.0016 0.5 0.5
0.0062 0.6935 0.7231
0.0037 1 0.5
0.0018 0.5 0.5
0.0029 0.5 0.5
0.0093 0.8828 0
0.0011 1 1
0.0023 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_136270 (Schistosoma mansoni), serine/threonine protein kinase
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