Detailed view for Smp_060950

Basic information

TDR Targets ID: 285309
Schistosoma mansoni, soluble NSF attachment protein (SNAP)
Source Database / ID:  GeneDB

pI: 5.6689 | Length (AA): 289 | MW (Da): 32485 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF14938   Soluble NSF attachment protein, SNAP

Gene Ontology

Mouse over links to read term descriptions.
GO:0005794   Golgi apparatus  
GO:0005783   endoplasmic reticulum  
GO:0005515   protein binding  
GO:0005488   binding  
GO:0006886   intracellular protein transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 287 3q15 (A) 64 349 15.00 0 1 1.10188 0.53
5 287 1qqe (A) 1 289 28.00 0.0000000021 1 1.29824 0.07
28 140 1zu2 (A) 0 122 31.00 0.66 0.5 0.495103 0.64
92 172 3sf4 (A) 291 370 19.00 0 0.97 0.618077 -0.89

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127387)

Species Accession Gene Product
Arabidopsis thaliana AT3G56190   alpha-soluble NSF attachment protein 2
Babesia bovis BBOV_II005240   SNAP protein, putative
Brugia malayi Bm1_52745   NSF attachment protein
Candida albicans CaO19.2518   Peripheral membrane protein.
Candida albicans CaO19.10054   Peripheral membrane protein.
Caenorhabditis elegans CELE_D1014.3   Protein SNAP-1
Cryptosporidium hominis Chro.20087   SNAP protein (soluble N-ethylmaleimide-sensitive factor Attachment Protein)
Cryptosporidium parvum cgd2_760   conserved hypothetical protein
Dictyostelium discoideum DDB_G0285111   soluble NSF attachment protein alpha isoform
Drosophila melanogaster Dmel_CG6625   alpha Soluble NSF attachment protein
Echinococcus granulosus EgrG_000906800   N ethylmaleimide sensitive factor attachment
Entamoeba histolytica EHI_064680   alpha-soluble NSF attachment protein, putative
Echinococcus multilocularis EmuJ_000906800   N ethylmaleimide sensitive factor attachment
Giardia lamblia GL50803_17224   Alpha-SNAP, putative
Homo sapiens ENSG00000105402   N-ethylmaleimide-sensitive factor attachment protein, alpha
Homo sapiens ENSG00000125814   N-ethylmaleimide-sensitive factor attachment protein, beta
Leishmania braziliensis LbrM.32.3140   hypothetical protein, conserved
Leishmania braziliensis LbrM.20.5850   soluble n-ethylmaleimide sensitive factor, putative
Leishmania donovani LdBPK_201660.1   soluble n-ethylmaleimide sensitive factor, putative
Leishmania donovani LdBPK_323040.1   SNAP protein, putative
Leishmania infantum LinJ.32.3040   hypothetical protein, conserved
Leishmania infantum LinJ.20.1660   soluble n-ethylmaleimide sensitive factor, putative
Leishmania major LmjF.20.1690   SNAP protein, putative
Leishmania major LmjF.32.2890   SNAP protein, putative
Leishmania mexicana LmxM.31.2890   hypothetical protein, conserved
Leishmania mexicana LmxM.20.1690   soluble n-ethylmaleimide sensitive factor, putative
Loa Loa (eye worm) LOAG_00033   NSF attachment protein
Mus musculus ENSMUSG00000006024   N-ethylmaleimide sensitive fusion protein attachment protein alpha
Mus musculus ENSMUSG00000027438   N-ethylmaleimide sensitive fusion protein attachment protein beta
Neospora caninum NCLIV_061620   hypothetical protein
Oryza sativa 9271886   Os01g0812600
Oryza sativa 4345167   Os08g0282400
Plasmodium berghei PBANKA_1108600   SNAP protein, putative
Plasmodium falciparum PF3D7_0509000   SNAP protein (soluble N-ethylmaleimide-sensitive factor attachment protein), putative
Plasmodium knowlesi PKNH_1024600   SNAP protein (soluble N-ethylmaleimide-sensitive factor attachment protein), putative
Plasmodium vivax PVX_098015   soluble NSF attachment protein (SNAP), putative
Plasmodium yoelii PY04299   beta-soluble nsf attachment protein
Saccharomyces cerevisiae YBL050W   Sec17p
Schistosoma japonicum Sjp_0200910   Alpha-soluble NSF attachment protein, putative
Schistosoma mansoni Smp_060950   soluble NSF attachment protein (SNAP)
Schmidtea mediterranea mk4.000693.04  
Schmidtea mediterranea mk4.000693.05   Soluble NSF attachment protein
Trypanosoma brucei gambiense Tbg972.11.18020   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.1.1890   soluble N-ethylmaleimide sensitive factor (NSF) attachment protein, putative
Trypanosoma brucei Tb927.11.16080   Soluble NSF attachment protein, SNAP, putative
Trypanosoma brucei Tb927.1.3110   soluble N-ethylmaleimide sensitive factor (NSF) attachment protein, putative
Trypanosoma congolense TcIL3000.11.16000   Soluble NSF attachment protein, SNAP, putative
Trypanosoma congolense TcIL3000_1_1490   soluble N-ethylmaleimide sensitive factor (NSF) attachment protein, putative
Trypanosoma cruzi TcCLB.509073.50   Soluble NSF attachment protein, SNAP, putative
Trypanosoma cruzi TcCLB.506363.150   soluble N-ethylmaleimide sensitive factor (NSF) attachment protein, putative
Trypanosoma cruzi TcCLB.508405.90   soluble N-ethylmaleimide sensitive factor (NSF) attachment protein, putative
Trypanosoma cruzi TcCLB.508707.160   Soluble NSF attachment protein, SNAP, putative
Toxoplasma gondii TGME49_218760   SNAP protein (soluble N-ethylmaleimide-sensitive factor Attachment Protein), putative
Theileria parva TP02_0828   SNAP protein (soluble N-ethylmaleimide-sensitive factor Attachment Protein), putative
Theileria parva TP02_0829   hypothetical protein
Trichomonas vaginalis TVAG_176230   soluble nsf attacment protein, putative

Essentiality

Smp_060950 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.1.3110 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.1.3110 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.1.3110 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.1.3110 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_D1014.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_D1014.3 Caenorhabditis elegans larval lethal wormbase
CELE_D1014.3 Caenorhabditis elegans slow growth wormbase
CELE_D1014.3 Caenorhabditis elegans sterile wormbase
YBL050W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1108600 Plasmodium berghei Essential plasmo
TGME49_218760 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_060950 (Schistosoma mansoni), soluble NSF attachment protein (SNAP)
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