pI: 7.362 |
Length (AA): 1546 |
MW (Da): 174773 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
10 | 422 | 2fo0 (A) | 78 | 529 | 24.00 | 0 | 1 | 0.322541 | 0.23 |
13 | 75 | 2rf0 (A) | 17 | 78 | 48.00 | 0 | 1 | 0.70215 | -1.43 |
17 | 70 | 6cpi (A) | 559 | 605 | 49.00 | 0.0058 | 0.64 | 0.444329 | -0.47 |
115 | 452 | 3war (A) | 5 | 323 | 18.00 | 0 | 1 | 0.331029 | 0.16 |
140 | 446 | 4uy9 (A) | 135 | 443 | 39.00 | 0 | 1 | 0.686977 | -1.1 |
149 | 548 | 6b1u (A) | 16 | 446 | 23.00 | 0 | 1 | 0.300132 | 0.97 |
245 | 347 | 5y86 (A) | 315 | 404 | 43.00 | 0.0012 | 0.61 | 0.220324 | 0.79 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128497)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G31170 | protein kinase family protein |
Arabidopsis thaliana | AT5G58950 | protein kinase family protein |
Arabidopsis thaliana | AT2G24360 | putative serine/threonine/tyrosine kinase |
Caenorhabditis elegans | CELE_K11D12.10 | Protein MLK-1, isoform B |
Dictyostelium discoideum | DDB_G0272254 | Kelch repeat-containing protein |
Dictyostelium discoideum | DDB_G0267514 | protein kinase, TKL group |
Drosophila melanogaster | Dmel_CG2272 | slipper |
Echinococcus granulosus | EgrG_000436900 | mitogen-activated protein kinase kinase kinase 9 |
Echinococcus multilocularis | EmuJ_000436900 | mitogen activated protein kinase kinase kinase |
Homo sapiens | ENSG00000173327 | mitogen-activated protein kinase kinase kinase 11 |
Homo sapiens | ENSG00000006432 | mitogen-activated protein kinase kinase kinase 9 |
Homo sapiens | ENSG00000130758 | mitogen-activated protein kinase kinase kinase 10 |
Homo sapiens | ENSG00000143674 | mixed lineage kinase 4 |
Mus musculus | ENSMUSG00000004054 | mitogen-activated protein kinase kinase kinase 11 |
Mus musculus | ENSMUSG00000040390 | mitogen-activated protein kinase kinase kinase 10 |
Mus musculus | ENSMUSG00000042724 | mitogen-activated protein kinase kinase kinase 9 |
Mus musculus | ENSMUSG00000031853 | cDNA sequence BC021891 |
Oryza sativa | 4344967 | Os08g0224100 |
Oryza sativa | 4336935 | Os04g0608900 |
Oryza sativa | 4327068 | Os01g0201200 |
Oryza sativa | 4328462 | Os02g0174200 |
Oryza sativa | 9271125 | Os01g0107300 |
Oryza sativa | 4339338 | Os05g0519200 |
Oryza sativa | 4325541 | Os01g0747400 |
Oryza sativa | 4341763 | Os06g0663400 |
Schistosoma mansoni | Smp_176580 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.008109.00 | Serine/threonine kinase |
Schmidtea mediterranea | mk4.007821.02 | |
Schmidtea mediterranea | mk4.039473.00 | |
Schmidtea mediterranea | mk4.008109.01 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase kinase 9 | Compounds | References |
Homo sapiens | mitogen-activated protein kinase kinase kinase 11 | Compounds | References |
Homo sapiens | mitogen-activated protein kinase kinase kinase 10 | Compounds | References |
Mus musculus | mitogen-activated protein kinase kinase kinase 11 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Jak1 protein | 210 aa | 29.0% | 217 aa | Compounds | References |
Gallus gallus | Tyrosine-protein kinase SRC | 533 aa | 24.5% | 473 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 29.3% | 157 aa | Compounds | References |