Detailed view for Smp_089670

Basic information

TDR Targets ID: 285440
Schistosoma mansoni, macroglobulin/complement
Source Database / ID:  GeneDB

pI: 5.2225 | Length (AA): 1941 | MW (Da): 222169 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00207   Alpha-2-macroglobulin family
PF07677   A-macroglobulin receptor
PF07678   A-macroglobulin complement component
PF10569   Alpha-macro-globulin thiol-ester bond-forming region

Gene Ontology

Mouse over links to read term descriptions.
GO:0005576   extracellular region  
GO:0016020   membrane  
GO:0005615   extracellular space  
GO:0005515   protein binding  
GO:0004866   endopeptidase inhibitor activity  
GO:0007154   cell communication  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
41 1799 3cu7 (A) 20 1510 16.00 0 1 0.706034 1.31
699 743 2wft (A) 625 668 45.00 0.00024 0.93 0.559984 -0.25
699 772 2m74 (A) 67 145 36.00 0.00000014 1 0.281925 0.85
1238 1564 1qqf (A) 1011 1286 25.00 0 1 0.32327 -0.84

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128918)

Species Accession Gene Product
Echinococcus granulosus EgrG_000641200   macroglobulin:complement
Echinococcus granulosus EgrG_000641250   delta protein like; bm interacting protein
Echinococcus granulosus EgrG_000644300   macroglobulin:complement
Echinococcus multilocularis EmuJ_000641100   alpha 2 macroglobulin
Echinococcus multilocularis EmuJ_000644300   macroglobulin:complement
Echinococcus multilocularis EmuJ_000641200   macroglobulin:complement
Homo sapiens 144203   ovostatin 2
Homo sapiens 100653225   ovostatin homolog 2-like
Homo sapiens ENSG00000126838   pregnancy-zone protein
Homo sapiens 408186   ovostatin
Homo sapiens ENSG00000166535   alpha-2-macroglobulin-like 1
Homo sapiens ENSG00000175899   alpha-2-macroglobulin
Homo sapiens 102724747   ovostatin homolog 2-like
Homo sapiens 102724702   ovostatin homolog 1-like
Mus musculus ENSMUSG00000030111   alpha-2-macroglobulin
Mus musculus ENSMUSG00000030359   pregnancy zone protein
Mus musculus ENSMUSG00000059908   murinoglobulin 1
Mus musculus ENSMUSG00000030131   murinoglobulin 2
Mus musculus ENSMUSG00000047228   cDNA sequence BC048546
Schistosoma japonicum Sjp_0062670   ko:K03910 alpha-2-macroglobulin, putative
Schistosoma japonicum Sjp_0062680   Delta-like protein B precursor, putative
Schistosoma mansoni Smp_089670   macroglobulin/complement
Schmidtea mediterranea mk4.004852.03  
Schmidtea mediterranea mk4.008429.02  
Schmidtea mediterranea mk4.033835.00  
Schmidtea mediterranea mk4.008692.00  
Schmidtea mediterranea mk4.043975.00  
Schmidtea mediterranea mk4.005639.01  
Schmidtea mediterranea mk4.008429.00  
Schmidtea mediterranea mk4.005639.00  
Schmidtea mediterranea mk4.005639.02  
Schmidtea mediterranea mk4.008429.03  
Schmidtea mediterranea mk4.014934.00  
Schmidtea mediterranea mk4.004852.05  
Schmidtea mediterranea mk4.004852.02  
Schmidtea mediterranea mk4.033835.01  
Schmidtea mediterranea mk4.008429.01  
Schmidtea mediterranea mk4.005639.03  
Schmidtea mediterranea mk4.018275.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0236 0.2616 0.6205
0.0019 0.4883 1
0.0021 0.374 0.0739
0.032879 0.535123 0.795649
0.0019 0.4883 1
0.0252 0.2627 0.5009
0.0018 0.4883 1
0.0051 0.3355 1
0.0018 0.4883 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_089670 (Schistosoma mansoni), macroglobulin/complement
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