Detailed view for Smp_060940.1

Basic information

TDR Targets ID: 285545
Schistosoma mansoni, protein kinase
Source Database / ID:  GeneDB

pI: 6.284 | Length (AA): 1068 | MW (Da): 119932 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
33 358 5v1d (C) 105 408 32.00 0 1 0.208543 0.92
33 305 4yzy (A) 104 355 34.00 0 0.89 -0.251082 1.61
619 1064 4x7k (A) 585 1078 53.00 0 1 0.094303 1.52
621 694 3biz (A) 293 368 46.00 0.0001 1 0.467988 0.3
626 713 2wqn (A) 33 115 30.00 0.0035 0.77 0.349097 -0.31
785 947 3ugc (A) 885 1064 26.00 0.000000036 0.12 0.336922 -0.47
851 894 2exe (A) 263 325 50.00 0.74 0.91 0.217899 0.73
853 1059 2bdw (A) 117 267 33.00 0.0017 0.74 -0.00747978 0.64
907 1064 5cem (A) 169 339 22.00 0.000000096 0.31 0.34024 -0.66

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133221)

Species Accession Gene Product
Brugia malayi Bm1_37470   Protein kinase domain containing protein
Caenorhabditis elegans CELE_F46C3.1   Protein PEK-1
Drosophila melanogaster Dmel_CG2087   pancreatic eIF-2alpha kinase
Homo sapiens ENSG00000172071   eukaryotic translation initiation factor 2-alpha kinase 3
Loa Loa (eye worm) LOAG_02433   PEK/PEK protein kinase
Mus musculus ENSMUSG00000031668   eukaryotic translation initiation factor 2 alpha kinase 3
Schistosoma japonicum Sjp_0005210   ko:K08860 eukaryotic translation initiation factor 2-alpha kinase, putative
Schistosoma mansoni Smp_060940.1   protein kinase
Schistosoma mansoni Smp_060940.2   protein kinase
Schmidtea mediterranea mk4.000175.08  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens eukaryotic translation initiation factor 2-alpha kinase 3 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0012 0.5 0.5
0.0959 0.8607 0.8607
0.0599 0.3178 0.3905
0.0888 0.3158 0.389
0.0029 0.5 0.5
0.0644 0.6289 0.5
0.0846 0.3145 0.324
0.0012 0.5 0.5
0.0628 1 1
0.0229 1 0.5
0.0832 0.3145 0.3178
0.1168 1 1
0.0844 0.3009 1
0.0616 0.2808 0.2808
0.0959 0.8607 0.8607
0.0402 0.3081 0.3801
0.0098 0.3242 0.2614
0.0062 0.6935 0.7231
0.0431 0.2631 0.7506
0.0832 0.3145 0.3178
0.0056 1 1
0.1393 1 1
0.0862 1 1
0.0228 0.6978 0.6978
0.0184 0.2665 0.2665
0.1593 0.3365 0.8606
0.0431 1 1
0.1225 0.8668 0.8668
0.0228 0.866 0.866
0.0661 1 1
0.0844 0.3009 1
0.0007 0.5 0.5
0.0195 0.2808 0.2808
0.0232 0.3203 0.6249
0.1323 0.3114 0.9433
0.0302437 0.320139 0.326384
0.0238 0.3081 0.3807
0.0229 1 1
0.0402 0.3155 0.3886
0.0228 0.5 0.5
0.0184 0.2665 0.2665
0.0208 0.2816 0.2808
0.0819 1 1
0.0661 0.3196 0.3934
0.0663 0.317 0.3354
0.1162 1 1
0.0228 0.8672 0.8672
0.1312 0.3326 0.4988
0.0228 0.8672 0.8672
0.0844 0.3009 1
0.062 0.3146 0.331
0.1212 0.8668 0.8668
0.0427 1 1
0.0228 0.8672 0.8672
0.1986 1 1
0.0198 0.2808 0.2808
0.1213 0.8673 0.8672
0.023 0.2862 0.286
0.0228 0.8672 0.8672
0.0198 0.2539 0.2539
0.0059 1 1
0.0959 0.8607 0.8607
0.1201 0.868 0.868
0.0596 0.6401 0.7526
0.1399 0.8668 0.8668
0.0228 0.8672 0.8672
0.1205 1 1
0.0378 0.3339 0.3339
0.0843 0.3217 0.3957
0.0437 0.3352 0.4418
0.0229 1 0.5
0.0784 1 1
0.0835 1 1
0.0628 0.3066 0.379
0.0669 0.7651 0.7651
0.1215 0.8668 0.8668
0.0007 0.5 0.5
0.3153 1 1
0.1642 1 1
0.1254 0.8706 0.8702
0.0596 0.6401 0.7526
0.0004 0.5 0.5
0.0219 1 1
0.0665 0.3021 0.3015
0.0591 1 1
0.0039 0.9485 1
0.0042 0.5 0.5
0.0184 0.2665 0.2665
0.0615 0.3224 0.3988
0.0572 0.3147 0.3907
0.0228 0.8672 0.8672
0.0616 0.317 0.3354
0.0596 0.6401 0.7526
0.0661 1 1
0.0383 0.9168 0.9166
0.0033 0.5 0.5
0.106737 0.413765 0.412944
0.0635 0.3067 0.3791
0.0202 0.2523 0.2523
0.0228 1 1
0.0018 0.5 0.5
0.0402 0.8368 0.9728
0.0642 0.3153 0.333
0.0203 1 1
0.0959 0.8607 0.8607
0.0749 0.8502 0.8494
0.0647 0.278 0.278
0.0862 1 1
0.0003 0.5 0.5
0.0231 0.2649 0.3116
0.0389 1 1
0.0228 0.8672 0.8672
0.0959 0.8607 0.8607
0.0032 0.5 0.5
0.0844 0.3009 1
0.0228 0.3127 1
0.1161 1 1
0.1323 0.3114 0.9433
0.0081 0.5 0.5
0.0514 0.2756 0.2999
0.0061 0.6883 0.6656
0.0384 0.3864 1
0.0817 0.3145 0.3184
0.0661 0.31 0.379
0.0845 0.3145 0.3153
0.0642 0.3146 0.333
0.0032 0.5 0.5
0.0204 1 1
0.0959 0.8607 0.8607
0.0804765 0.406254 0.405647
0.1256 0.8668 0.8668
0.0228 1 1
0.0064 0.3377 0.9531
0.0238 0.3081 0.3807
0.0023 0.5 0.5
0.0642 0.3146 0.333
0.3338 1 1
0.3238 1 1
0.1301 1 1
0.0855 0.3066 0.379
0.0228 0.8672 0.8672
0.0635 0.3067 0.3791
0.0093 0.8828 0
0.0893 0.3156 0.389
0.0228 0.8672 0.8672
0.0816 0.8325 1
0.0232 0.6217 0.6163
0.0067 0.5 0.5
0.0022 0.5 0.5
0.3184 1 1
0.1046 0.8709 0.8709
0.0397 0.3171 0.3665
0.1794 1 0.5
0.0224 0.2834 0.2834
0.0063 1 1
0.0229 0.4109 0.4078
0.0203 1 1
0.0228 0.3387 0.1835
0.1593 0.2921 1
0.0228 0.2729 0.6962
0.0066 0.3101 0.9479
0.1199 1 1
0.1766 1 1
0.0821 0.8361 0.9849
0.0596 0.6401 0.7526
0.0199 0.9154 0.9154
0.0228 0.2695 1
0.0853 0.3127 0.3835
0.062 0.3115 0.3835
0.0059 1 1
0.0843 0.3217 0.3957
0.1301 1 1
0.0848 0.3081 0.379
0.0522 0.3176 0.3256
0.0797 0.8126 1
0.0641 0.3158 0.389
0.0835 1 1
0.0848 0.3081 0.379
0.064 0.3106 0.3835
0.168553 1 1
0.0646 1 0.5
0.0199 0.2647 0.2647
0.0199 0.9154 0.9154
0.0012 0.5 0.5
0.0656 1 1
0.0804765 0.406254 0.405647
0.0184 0.2665 0.2665
0.0228 0.3659 0.3659
0.0228 0.8672 0.8672
0.0228 0.8672 0.8672
0.0037 1 0.5
0.063 0.2808 0.2808
0.0514 0.2756 0.2999
0.0036 0.5 0.5
0.0837729 0.417363 0.51541
0.024 0.2829 0.282
0.0184 0.2665 0.2665
0.0437 0.3352 0.4418
0.0228 0.8672 0.8672
0.0514 0.2756 0.2999
0.0622 0.6732 0.7432
0.1301 1 1
0.0081 1 1
0.0625 1 1
0.0235 0.3122 0.3876
0.0229 1 1
0.0398 0.2836 0.2836
0.0593 1 1
0.0813 0.8293 1
0.0812 0.3299 1
0.0959 0.8607 0.8607
0.0184 0.2665 0.2665
0.024 0.3032 0.3704
0.0403 1 1
0.0011 1 1
0.0069 0.3067 0.3067
0.0059 1 1
0.0374 1 1
0.0208 0.2788 0.5795
0.0228 0.8672 0.8672
0.0228 1 1
0.0088 0.4477 0.6337
0.0229 1 0.5
0.0591 1 1
0.0228 1 1
0.0228 0.2677 0.1996
0.0593 1 1
0.3285 0.271 0.295
0.0812 0.8264 0.9732
0.0228 0.73 1
0.0228 0.2771 1
0.0228 0.8672 0.8672
0.0959 0.8607 0.8607
0.0016 0.5 0.5
0.0238 0.3081 0.3807
0.0229 0.8687 0.8687
0.165443 1 1
0.0228 1 1
0.0228 0.5586 1
0.0657 0.3115 0.3835
0.0027 1 1
0.0809 1 1
0.0853 0.3124 0.3835
0.0302437 0.320139 0.326384
0.0397 0.6533 1
0.0206 0.2794 0.278
0.0596 0.6401 0.7526
0.1617 1 0.5
0.0514 0.2756 0.2999
0.0669 0.7651 0.7651
0.0998 1 1
0.0886 0.318 0.3901
0.0824 1 1
0.137 1 1
0.0039 0.5 0.5
0.0848 0.3144 0.3152
0.0631 0.3066 0.379
0.0228 0.4188 1
0.1017 0.5458 1
0.0626 0.3146 0.3345
0.0229 1 0.5
0.1323 0.3114 0.9433
0.3316 1 1
0.0883 0.318 0.3901
0.0824 0.3145 0.3173
0.024 0.2829 0.282
0.0026 0.5 0.5
0.0665 0.3066 0.379
0.0603 0.3146 0.3355
0.1593 0.2921 1
0.0959 0.8607 0.8607
0.0622 0.3066 0.379
0.0845 0.3066 0.379
0.0874 0.31 0.379
0.0063 0.7244 0
0.0858 0.3145 0.3154
0.0377 0.3152 0.3909
0.1254 0.8706 0.8702
0.0821 0.8361 0.9849
0.3171 1 1
0.0007 0.5 0.5
0.0959 0.8607 0.8607
0.0656 0.3156 0.389
0.0635 0.3067 0.3791
0.0607 0.3121 0.3835
0.3101 0.6009 0.6009
0.0033 1 1
0.0665 0.3168 0.3903
0.0665 0.3021 0.3015
0.36 0.6013 1
0.0008 0.5 0.5
0.0874 0.3081 0.379
0.0092 1 1
0.0637 0.3167 0.3901
0.0228 0.8672 0.8672
0.0204 1 1
0.0855 0.3145 0.3235
0.0229 1 1
0.0395 0.8295 0.9644
0.0204 0.2808 0.2808
0.0039 0.5 0.5
0.0843 0.3217 0.3957
0.0239 0.301 0.369
0.0514 0.2756 0.2999
0.1323 0.3114 0.9433
0.3173 1 1
0.3285 0.271 0.295
0.0228 0.3831 0.3831
0.0228 1 1
0.1323 0.3114 0.9433
0.0614 0.3146 0.333
0.0809 1 1
0.0239 0.313 0.3879
0.0229 0.5002 0.488
0.1009 0.8502 0.8494
0.0198 0.2628 0.2622
0.0229 0.87 0.87
0.0016 0.5 0.5
0.0894 0.3157 0.3887
0.1563 1 1
0.0836 0.3168 0.3249
0.0242 0.3118 0.3795
0.0853 0.3144 0.3151
0.0228 0.8672 0.8672
0.0091 1 1
0.0228 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_060940.1 (Schistosoma mansoni), protein kinase
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