Detailed view for Smp_090080

Basic information

TDR Targets ID: 285612
Schistosoma mansoni, serpin
Source Database / ID:  GeneDB

pI: 5.9441 | Length (AA): 406 | MW (Da): 46006 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00079   Serpin (serine protease inhibitor)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005615   extracellular space  
GO:0004867   serine-type endopeptidase inhibitor activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
17 403 3sto (A) 17 403 72.00 0.0000000023 1 1.8411 -1.42
375 406 2r9y (A) 382 413 34.00 0.0056 0.07 0.0537177 3.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132248)

Species Accession Gene Product
Echinococcus granulosus EgrG_000824000   Estrogen regulated protein EP45
Echinococcus multilocularis EmuJ_000824000   Estrogen regulated protein EP45
Echinococcus multilocularis EmuJ_000824100   Estrogen regulated protein EP45
Homo sapiens ENSG00000100665   serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
Homo sapiens ENSG00000197249   serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Mus musculus ENSMUSG00000066366   serine (or cysteine) peptidase inhibitor, clade A, member 1A
Mus musculus ENSMUSG00000071177   serine (or cysteine) peptidase inhibitor, clade A, member 1D
Mus musculus ENSMUSG00000071178   serine (or cysteine) preptidase inhibitor, clade A, member 1B
Mus musculus ENSMUSG00000079015   serine (or cysteine) peptidase inhibitor, clade A, member 1C
Mus musculus ENSMUSG00000072849   serine (or cysteine) peptidase inhibitor, clade A, member 1E
Schistosoma japonicum Sjp_0113720   Serpin B11, putative
Schistosoma japonicum Sjp_0215470   Neuroserpin precursor, putative
Schistosoma japonicum Sjp_0097160   IPR000215,Proteinase inhibitor I4, serpin,domain-containing
Schistosoma japonicum Sjp_0023570   Neuroserpin precursor, putative
Schistosoma japonicum Sjp_0312250   Glia-derived nexin precursor, putative
Schistosoma mansoni Smp_090090   serpin
Schistosoma mansoni Smp_003300   serine protease inhibitors serpins
Schistosoma mansoni Smp_090080   serpin
Schmidtea mediterranea mk4.008630.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Plasminogen activator inhibitor-1 402 aa 23.6% 369 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0011 0.5 0.5
0.0012 0.5 0.5
0.0011 0.5 0.5
0.0017 0.3884 0.5586
0.0036 1 0.5
0.0007 0.5 0.5
0.0124 0.7236 1
0.0025 0.5 0.5
0.0115 0.5 0.5
0.0087 0.5 0.5
0.0018 1 1
0.0122 0.4261 0.3502
0.0044 0.5 0.5
0.0044 0.5 0.5
0.002 0.4132 0.3859

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_090080 (Schistosoma mansoni), serpin
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