pI: 5.8314 |
Length (AA): 657 |
MW (Da): 71955 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 34 | 1ja9 (A) | 25 | 57 | 58.00 | 0 | 0.79 | 0.731828 | -0.66 |
3 | 450 | 2et6 (A) | 5 | 503 | 17.00 | 0 | 1 | 0.494787 | 0.94 |
4 | 230 | 3gaf (A) | 9 | 204 | 28.00 | 0 | 1 | 0.58141 | -0.29 |
4 | 100 | 3sx2 (A) | 9 | 108 | 32.00 | 0.0066 | 0.99 | 0.654641 | -1.5 |
294 | 485 | 3ksu (A) | 69 | 245 | 32.00 | 0.57 | 0.78 | 0.375237 | 0.33 |
328 | 509 | 1o5i (A) | 71 | 234 | 18.00 | 0 | 0.39 | 0.274917 | 0.78 |
525 | 641 | 2uwm (A) | 491 | 605 | 28.00 | 0.83 | 0.11 | 0.405982 | 0.2 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_134637)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_31830 | dehydrogenases, short chain protein 9 |
Caenorhabditis elegans | CELE_Y32H12A.3 | Protein DHS-9 |
Echinococcus granulosus | EgrG_000410100 | Dehydrogenase:reductase SDR family |
Echinococcus multilocularis | EmuJ_000410100 | Dehydrogenase:reductase SDR family |
Homo sapiens | ENSG00000157379 | dehydrogenase/reductase (SDR family) member 1 |
Loa Loa (eye worm) | LOAG_07388 | dehydrogenase |
Mus musculus | ENSMUSG00000002332 | dehydrogenase/reductase (SDR family) member 1 |
Mycobacterium ulcerans | MUL_2755 | oxidoreductase |
Schistosoma japonicum | Sjp_0214470 | ko:K00120 similar to Dehydrogenase/reductase (SDR family) member 1 [EC:1.1.-.-], putative |
Schistosoma japonicum | Sjp_0214460 | ko:K00120 Dehydrogenase/reductase (SDR family) member 1 [EC:1.1.-.-], putative |
Schistosoma japonicum | Sjp_0057930 | Dehydrogenase/reductase SDR family member 1, putative |
Schistosoma japonicum | Sjp_0219320 | expressed protein |
Schistosoma mansoni | Smp_171960 | short chain dehydrogenase |
Schistosoma mansoni | Smp_171030 | short chain dehydrogenase |
Schmidtea mediterranea | mk4.041724.01 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Bacillus subtilis (strain 168) | Enoyl-[acyl-carrier-protein] reductase [NADH] | 258 aa | 24.8% | 262 aa | Compounds | References |
Canis lupus familiaris | 11-beta-hydroxysteroid dehydrogenase type 1 | 293 aa | 25.1% | 243 aa | Compounds | References |
Trypanosoma brucei | pteridine reductase 1 | 268 aa | 26.6% | 222 aa | Compounds | References |