pI: 8.0634 |
Length (AA): 470 |
MW (Da): 52330 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 10
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
18 | 419 | 4iu9 (A) | 22 | 450 | 19.00 | 0 | 0.61 | 0.942419 | 0.03 |
24 | 424 | 3wdo (A) | 10 | 388 | 17.00 | 0 | 0.85 | 0.999291 | -0.03 |
25 | 443 | 5c65 (A) | 5 | 464 | 13.00 | 0.00000000014 | 0.04 | 0.915889 | -0.29 |
321 | 445 | 5v8k (A) | 131 | 250 | 32.00 | 0.13 | 0.02 | 0.0520574 | 3.11 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129874)
Species | Accession | Gene Product |
---|---|---|
Cryptosporidium hominis | Chro.40463 | RIKEN cDNA 1200003O06 |
Cryptosporidium parvum | cgd4_4050 | putative transporter with signal peptide and 12 transmembrane domains |
Dictyostelium discoideum | DDB_G0289201 | major facilitator superfamily domain-containing protein 1 |
Drosophila melanogaster | Dmel_CG8602 | CG8602 gene product from transcript CG8602-RA |
Drosophila melanogaster | Dmel_CG12194 | CG12194 gene product from transcript CG12194-RA |
Echinococcus granulosus | EgrG_000190800 | major facilitator superfamily domain containing protein |
Echinococcus multilocularis | EmuJ_000190800 | major facilitator superfamily domain containing protein |
Homo sapiens | ENSG00000118855 | major facilitator superfamily domain containing 1 |
Leishmania donovani | LdBPK_280150.1 | major facilitator superfamily, putative |
Leishmania infantum | LinJ.28.0150 | hypothetical protein, conserved |
Leishmania major | LmjF.28.0150 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.28.0150 | hypothetical protein, conserved |
Mus musculus | ENSMUSG00000027775 | major facilitator superfamily domain containing 1 |
Schistosoma japonicum | Sjp_0022220 | Major facilitator superfamily domain-containing protein 1, putative |
Schistosoma mansoni | Smp_123280 | transport proetin (smap-4-related) |
Schmidtea mediterranea | mk4.000070.05 | Transport proetin |
Schmidtea mediterranea | mk4.015023.00 | Transport proetin |
Schmidtea mediterranea | mk4.013707.01 | Transport proetin |
Trypanosoma brucei gambiense | Tbg972.11.8340 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.11.7300 | major facilitator superfamily, putative |
Trypanosoma congolense | TcIL3000_0_00880 | major facilitator superfamily, putative |
Trypanosoma cruzi | TcCLB.506779.90 | major facilitator superfamily, putative |
Trypanosoma cruzi | TcCLB.511153.110 | major facilitator superfamily, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.5200 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.5200 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.5200 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.02.5200 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.