Detailed view for LmjF.01.0210

Basic information

TDR Targets ID: 28628
Leishmania major, hypothetical protein, conserved

Source Database / ID:  TriTrypDB  GeneDB

pI: 6.7213 | Length (AA): 897 | MW (Da): 95971 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01713   Smr domain
PF02845   CUE domain
PF08590   Domain of unknown function (DUF1771)

Gene Ontology

Mouse over links to read term descriptions.
GO:0046872   metal ion binding  
GO:0008270   zinc ion binding  
GO:0005515   protein binding  
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
563 611 1otr (A) 7 54 23.00 0.0000033 0.43 0.45 -1.91
807 889 2d9i (A) 6 90 25.00 0.000017 0.93 0.39 -0.78
4 50 1wji (A) 4 51 40.00 0.16 1 0.672397 -1.55
497 598 5if3 (A) 106 240 32.00 0.048 0.02 0.218712 1.72
806 892 3qd7 (X) 82 170 14.00 0.0000026 0.7 0.38889 -1.48
810 882 2d9i (A) 9 86 32.00 0.16 0.7 0.443382 -0.47
824 892 4od6 (A) 702 766 22.00 0.2 0.77 0.281823 -0.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein


Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.


Ortholog group members (OG5_132675)

Species Accession Gene Product
Candida albicans CaO19.2246   similar to S. cerevisiae YPL199C
Candida albicans CaO19.9786   similar to S. cerevisiae YPL199C
Dictyostelium discoideum DDB_G0268232   small MutS related family protein
Leishmania braziliensis LbrM.01.0240   hypothetical protein, conserved
Leishmania donovani LdBPK_010210.1   CUE domain/Domain of unknown function (DUF1771)/Smr domain containing protein, putative
Leishmania infantum LinJ.01.0210   hypothetical protein, conserved
Leishmania major LmjF.01.0210   hypothetical protein, conserved
Leishmania mexicana LmxM.01.0210   hypothetical protein, conserved
Saccharomyces cerevisiae YPL199C   hypothetical protein
Trypanosoma brucei gambiense Tbg972.9.1750   hypothetical protein, conserved
Trypanosoma brucei Tb927.9.3460   zinc finger protein family member, putative
Trypanosoma congolense TcIL3000_9_1020   zinc finger protein family member, putative
Trypanosoma cruzi TcCLB.511577.30   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.504797.110   hypothetical protein, conserved
Trichomonas vaginalis TVAG_004260   conserved hypothetical protein


LmjF.01.0210 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.2090 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.2090 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb09.160.2090 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.2090 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site,, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.01.0210 (Leishmania major), hypothetical protein, conserved
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