Detailed view for Smp_131870

Basic information

TDR Targets ID: 286765
Schistosoma mansoni, syntaxin binding protein-123
Source Database / ID:  GeneDB

pI: 7.2441 | Length (AA): 625 | MW (Da): 70965 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00995   Sec1 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016192   vesicle-mediated transport  
GO:0006904   vesicle docking during exocytosis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 601 4jeh (A) 4 587 56.00 0 1 1.62 -0.96
2 602 1epu (A) 2 591 64.00 0 1 1.672 -0.78

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127453)

Species Accession Gene Product
Arabidopsis thaliana AT1G12360   SNARE-interacting protein KEULE
Arabidopsis thaliana AT4G12120   protein transport sec1b
Arabidopsis thaliana AT1G02010   protein transporter sec1a
Babesia bovis BBOV_I002210   syntaxin binding protein, putative
Brugia malayi Bm1_16115   acetylcholine regulator unc-18
Candida albicans CaO19.6479   SNARE binding, late stage of secretion
Candida albicans CaO19.13833   SNARE binding, late stage of secretion
Candida albicans CaO19_6479   hypothetical protein
Caenorhabditis elegans CELE_F27D9.1   Protein UNC-18, isoform B
Cryptosporidium hominis Chro.80127   syntaxin binding protein
Cryptosporidium parvum cgd8_1080   STXBP/UNC-18/SEC1 syntaxin involved in golgi transport
Dictyostelium discoideum DDB_G0283937   Sec1-like family protein
Drosophila melanogaster Dmel_CG15811   Ras opposite
Echinococcus granulosus EgrG_000380500   syntaxin binding protein 1
Entamoeba histolytica EHI_093130   Sec1 family protein
Echinococcus multilocularis EmuJ_000380500   syntaxin binding protein 1
Homo sapiens ENSG00000136854   syntaxin binding protein 1
Homo sapiens ENSG00000076944   syntaxin binding protein 2
Leishmania braziliensis LbrM.26.2180   syntaxin binding protein 1, putative
Leishmania donovani LdBPK_262270.1   syntaxin binding protein 1, putative
Leishmania infantum LinJ.26.2270   syntaxin binding protein 1, putative
Leishmania major LmjF.26.2260   Sec1/Munc18 related protein, putative
Leishmania mexicana LmxM.26.2260   syntaxin binding protein 1, putative
Loa Loa (eye worm) LOAG_08180   uncoordinated protein 18
Loa Loa (eye worm) LOAG_07804   acetylcholine regulator unc-18
Mus musculus ENSMUSG00000026797   syntaxin binding protein 1
Mus musculus ENSMUSG00000004626   syntaxin binding protein 2
Neospora caninum NCLIV_016920   hypothetical protein
Oryza sativa 4335313   Os04g0252400
Oryza sativa 4340037   Os06g0135900
Plasmodium berghei PBANKA_0112000   syntaxin binding protein, putative
Plasmodium falciparum PF3D7_0613700   syntaxin binding protein, putative
Plasmodium knowlesi PKNH_1136300   syntaxin binding protein, putative
Plasmodium vivax PVX_113820   syntaxin binding protein, putative
Plasmodium yoelii PY05107   syntaxin binding protein 1
Saccharomyces cerevisiae YDR164C   Sec1p
Schistosoma japonicum Sjp_0007200   Protein ROP, putative
Schistosoma mansoni Smp_131870   syntaxin binding protein-123
Schmidtea mediterranea mk4.001900.05  
Schmidtea mediterranea mk4.001950.04   Protein ROP
Schmidtea mediterranea mk4.003677.01   Protein ROP
Schmidtea mediterranea mk4.001950.03   Protein ROP
Trypanosoma brucei gambiense Tbg972.9.660   syntaxin binding protein 1, putative
Trypanosoma brucei Tb927.9.1970   syntaxin binding protein 1, putative
Trypanosoma congolense TcIL3000_9_450   syntaxin binding protein 1, putative
Trypanosoma cruzi TcCLB.506737.140   syntaxin binding protein 1, putative
Toxoplasma gondii TGME49_240740   Sec1 family protein
Theileria parva TP03_0108   syntaxin binding protein, putative
Trichomonas vaginalis TVAG_364050   syntaxin binding protein-1,2,3, putative

Essentiality

Smp_131870 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.0780 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.160.0780 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.160.0780 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.0780 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F27D9.1 Caenorhabditis elegans sterile wormbase
YDR164C Saccharomyces cerevisiae inviable yeastgenome
TGME49_240740 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_131870 (Schistosoma mansoni), syntaxin binding protein-123
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