Detailed view for Smp_069400

Basic information

TDR Targets ID: 286898
Schistosoma mansoni, regulator of G protein signaling
Source Database / ID:  GeneDB

pI: 9.9915 | Length (AA): 247 | MW (Da): 28375 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00615   Regulator of G protein signaling domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004871   signal transducer activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 177 6n9g (A) 277 449 27.00 0 1 1.1606 -1.08
50 176 2bv1 (A) 62 187 39.00 0.000000066 1 1.24327 -2.55
50 176 2ihd (A) 46 172 50.00 0.000000033 1 1.35627 -2.58
52 176 2oj4 (A) 3 127 54.00 0 1 1.38187 -2.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134554)

Species Accession Gene Product
Brugia malayi Bm1_00135   regulator of G-protein signaling rgs-7
Caenorhabditis elegans CELE_F56B6.2   Protein RGS-7, isoform G
Echinococcus granulosus EgrG_000518700   regulator of G protein signaling 3
Echinococcus granulosus EgrG_000422200   regulator of G protein signaling 3
Echinococcus multilocularis EmuJ_000422200   regulator of G protein signaling 3
Echinococcus multilocularis EmuJ_000518500   regulator of G protein signaling
Echinococcus multilocularis EmuJ_000518700   regulator of G protein signaling 3
Homo sapiens ENSG00000135824   regulator of G-protein signaling 8
Loa Loa (eye worm) LOAG_09419   hypothetical protein
Mus musculus ENSMUSG00000042671   regulator of G-protein signaling 8
Schistosoma japonicum Sjp_0104130   IPR000342,Regulator of G protein signalling,domain-containing
Schistosoma japonicum Sjp_0120180   Regulator of G-protein signaling 4, putative
Schistosoma japonicum Sjp_0113160   Regulator of G-protein signaling 3, putative
Schistosoma japonicum Sjp_0037980   Regulator of G-protein signaling 3, putative
Schistosoma mansoni Smp_069400   regulator of G protein signaling
Schistosoma mansoni Smp_062760   regulator of G protein signaling
Schmidtea mediterranea mk4.005564.00  
Schmidtea mediterranea mk4.005524.02  
Schmidtea mediterranea mk4.002441.00  
Schmidtea mediterranea mk4.003591.03  
Schmidtea mediterranea mk4.000672.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens regulator of G-protein signaling 8 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.2577 0.2629 1
0.2527 0.2615 1
0.2201 0.2584 1
0.2572 0.2636 1
0.1768 0.2698 1
0.2449 0.264 1
0.1044 0.2783 1
0.2386 0.2729 1
0.2212 0.261 1
0.1204 0.2592 1
0.2689 0.2643 1
0.1819 0.2677 1
0.1937 0.2674 1
0.1625 0.2682 1
0.1781 0.256 1
0.2394 0.259 1
0.1562 0.2544 1
0.1809 0.2674 1
0.2185 0.2579 1
0.0874 0.2853 1
0.1964 0.26 1
0.1318 0.2523 1
0.2055 0.2566 1
0.0549 0.2628 1
0.2318 0.2624 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_069400 (Schistosoma mansoni), regulator of G protein signaling
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