Detailed view for Smp_163900

Basic information

TDR Targets ID: 287218
Schistosoma mansoni, dopamine-beta-monooxygenase
Source Database / ID:  GeneDB

pI: 5.4064 | Length (AA): 499 | MW (Da): 57790 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01082   Copper type II ascorbate-dependent monooxygenase, N-terminal domain
PF03712   Copper type II ascorbate-dependent monooxygenase, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016715   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen  
GO:0005507   copper ion binding  
GO:0004500   dopamine beta-monooxygenase activity  
GO:0004497   monooxygenase activity  
GO:0003824   catalytic activity  
GO:0006584   catecholamine metabolic process  
GO:0055114   oxidation reduction  
GO:0009987   cellular process  

Metabolic Pathways

Tyrosine metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
25 498 4zel (A) 47 521 32.00 0 1 1.256 0.69

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129281)

Species Accession Gene Product
Caenorhabditis elegans CELE_H13N06.6   Protein TBH-1, isoform A
Drosophila melanogaster Dmel_CG1543   Tyramine beta hydroxylase
Drosophila melanogaster Dmel_CG12673   CG12673 gene product from transcript CG12673-RC
Drosophila melanogaster Dmel_CG5235   CG5235 gene product from transcript CG5235-RA
Homo sapiens ENSG00000079931   monooxygenase, DBH-like 1
Homo sapiens ENSG00000123454   dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Mus musculus ENSMUSG00000000889   dopamine beta hydroxylase
Mus musculus ENSMUSG00000020000   monooxygenase, DBH-like 1
Schistosoma japonicum Sjp_0056290   ko:K00503 dopamine beta-monooxygenase [EC1.14.17.1], putative
Schistosoma mansoni Smp_163900   dopamine-beta-monooxygenase
Schmidtea mediterranea mk4.004025.00   Tyramine beta-hydroxylase
Schmidtea mediterranea mk4.023093.01   Tyramine beta-hydroxylase
Schmidtea mediterranea mk4.013099.01   Tyramine beta-hydroxylase
Schmidtea mediterranea mk4.013099.00   Tyramine beta-hydroxylase
Schmidtea mediterranea mk4.024379.00   Tyramine beta-hydroxilase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens dopamine beta-hydroxylase (dopamine beta-monooxygenase) Compounds References
Bos taurus Dopamine beta-hydroxylase Compounds References
Rattus norvegicus Dopamine beta-hydroxylase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1381 0.7935 1
0.0226 0.9128 1
0.0742 0.8909 1
0.0743 0.3265 0.3264
0.0733 0.8922 1
0.3243 0.8397 1
0.1443 0.4194 1
0.1443 0.2538 0.2538
0.507 0.6151 0.6151
0.0763 0.7836 0.7816
0.0129 0.5103 0.51
0.0377 0.4295 0.4216
0.0122 0.365 0
0.0699 0.8669 1
0.014 0.4072 0.4072
0.051 0.3176 0.3176
0.0248 0.6499 1
0.0378 0.2524 0.251
0.0717 0.8758 1
0.4486 0.3246 0.9002
0.049 0.602 1
0.0228 0.2772 1
0.0231 0.5044 0.4921
0.0248 0.3266 0.3266
0.0487 0.4641 0.4769
0.1443 0.2538 0.2538
0.2227 0.5699 0.5699
0.1443 0.2538 0.2538
0.0453 0.5435 0.6714
0.0367 0.365 0
0.0464 0.5363 0.5363
0.0725 0.8925 1
0.0479 0.5811 0.6849
0.0743 0.3265 0.3264
0.2227 0.5699 0.5699
0.1658 0.3295 0.5221
0.0753 0.7352 0.7623
0.0702 0.3252 0.3252
0.1443 0.2538 0.2538
0.0377 0.5015 0.4965
0.0133 0.4748 0.4461
0.1447 0.8475 1
0.0367 0.4094 0.4094
0.0777 0.81 0.8046
0.069 0.3996 1
0.0227 0.2596 0.2578
0.0763 0.7597 0.7594
0.0252 0.3469 0.3324
0.1443 0.4194 1
0.1447 0.8475 1
0.1447 0.8475 1
0.0253 0.7855 0.7855
0.0725 0.8932 1
0.051 0.3176 0.3176
0.1443 0.4194 1
0.016782 0.379325 0.404629
0.0779 0.589 0.589
0.071 0.2816 0.8866
0.2227 0.5699 0.5699
0.0692 0.9683 0.9683
0.0461 0.581 0.581
0.069 0.3996 1
0.0267 0.3581 0.1379
0.263 0.568 0.568
0.0804 0.3323 0.3323
0.0741 0.7723 0.7723
0.1722 0.8879 1
0.0239 0.9865 1
0.0601 0.5296 0.5296
0.0648 0.2955 0.2949
0.0132 0.2616 0.2434
0.0226 0.7771 0.8222
0.0743 0.3265 0.3264
0.0461 0.581 0.581
0.1443 0.2538 0.2538
0.1443 0.2538 0.2538
0.0941 0.4825 0.6278
0.1447 0.8475 1
0.0399 0.2853 0.5185
0.1443 0.2538 0.2538
0.0123 0.3581 0
0.0103 0.4175 0.4063
0.0728 0.8677 0.8677
0.1443 0.2538 0.2538
0.0121 0.4855 0.5094
0.0129 0.4364 0.4087
0.0255 0.3037 0.3288
0.0498 0.5929 1
0.0722 0.5937 0.5937
0.0792 0.3382 0.6338
0.0373 0.5154 0.5109
0.0743 0.3265 0.3264
0.2227 0.5699 0.5699
0.0737 0.7399 0.7399
0.07 0.8765 1
0.0283 0.9912 0.9912
0.0486 0.5925 1
0.079 0.7679 0.7679
0.0937 0.3471 0.4925
0.1443 0.2538 0.2538
0.072 0.8571 1
0.2227 0.5699 0.5699
0.0765 0.7638 0.7617
0.0124 0.365 0.1345
0.1443 0.2538 0.2538
0.0683 0.2673 1
0.0118 0.5208 0.5191
0.0283 0.7917 1
0.0385 0.4958 0.4958
0.1722 0.8879 1
0.069 0.3996 1
0.0238 0.2681 0.2681
0.0498 0.5929 1
0.0704 0.9458 0.9458
0.0759 0.8905 1
0.0119 0.2711 0.2681
0.071 0.5052 0.5051
0.0226 0.7399 1
0.0763 0.3605 0.5186
0.0628 0.4055 0.4924
0.0119 0.2711 0.2681
0.3243 0.8397 1
0.0123 0.3581 0
0.1443 0.8967 1
0.0283 0.2927 1
0.1413 0.5977 0.9238
0.0238 0.281 1
0.0935 0.4135 1
0.0121 0.4855 0.5094
0.0941 0.4825 0.6278
0.0243 0.3581 0
0.2227 0.5699 0.5699
0.0792 0.3382 0.6338
0.0399 0.2853 0.5185
0.071 0.7548 0.7548
0.0493 0.3878 0.3878
0.0742 0.8909 1
0.012 0.5085 0.5085
0.0422 0.3581 0
0.0244 0.3581 0
0.1443 0.8967 1
0.263 0.568 0.568
0.0552 0.5588 0.5577
0.0118 0.5208 0.5191
0.0135 0.3132 0.3132
0.0702 0.3252 0.3252
0.0394 0.3907 0.4608
0.012 0.5085 0.5085
0.0628 0.5056 0.5035
0.012 0.4841 0.4927
0.263 0.568 0.568
0.0792 0.3382 0.6338
0.0681 0.4116 0.9235
0.0771 0.7667 0.7667
0.0285 0.365 0
0.0246 0.4798 0.4676
0.0205 0.5195 0.5195
0.0453 0.2887 0.2887
0.0248 0.3266 0.3266
0.0704 0.6867 1
0.1443 0.4194 1
0.0565 0.3781 0.378
0.0735 0.4551 1
0.0695 0.8767 1
0.2785 0.7082 1
0.0236 0.2682 0.5485
0.0233 0.6865 1
0.0775 0.773 0.7708
0.0725 0.8871 1
0.0848 0.517 0.6944
0.0752 0.7549 0.7547
0.1443 0.2538 0.2538
0.0759 0.5264 0.5264
0.0748 0.6366 0.6366
0.073 0.3906 1
0.0702 0.3252 0.3252
0.0729 0.7464 0.7464
0.0121 0.2958 0.4082
0.1447 0.8475 1
0.0723 0.7307 0.7727
0.0121 0.4172 0.4172
0.0765 0.7619 0.7617
0.0574 0.3581 0.0946
0.0761 0.4606 0.4605
0.0244 0.9787 1
0.0754 0.2535 0.2535
0.089 0.4039 0.4039
0.1443 0.2538 0.2538
0.0251 0.4861 0.4783
0.1447 0.8461 1
0.0506 0.4663 0.4538
0.0848 0.279 0.279
0.0263 0.5118 0.5105
0.1443 0.4194 1
0.2227 0.5699 0.5699
0.0817 0.845 0.8435
0.0373 0.5015 0.4965
0.0712 0.5959 0.5959
0.1443 0.2538 0.2538
0.0248 0.3943 0.5144
0.0805 0.8514 0.8501
0.0699 0.3676 0.9717
0.0779 0.589 0.589
0.1443 0.4194 1
0.1443 0.2538 0.2538
0.0735 0.4551 1
0.0702 0.3252 0.3252
0.2227 0.5699 0.5699
0.0565 0.3781 0.378
0.069 0.3996 1
0.0941 0.4825 0.6278
0.0249 0.33 0
0.0139 0.4285 0.4072
0.0694 0.6947 0.6947
0.0478 0.4815 0.567
0.075 0.8149 1
0.0283 0.5738 0.6184
0.0781 0.52 0.52
0.0129 0.5067 0.5067
0.0702 0.3252 0.3252
0.0777 0.7613 0.761
0.0733 0.8915 1
0.0395 0.3693 0.3675
0.0699 0.3676 0.9717
0.1443 0.2538 0.2538
0.2227 0.5699 0.5699
0.072 0.8855 1
0.0694 0.868 1
0.012 0.5155 0.5085
0.0804 0.3323 0.3323
0.0124 0.3581 0
0.0479 0.5811 0.6849
0.0367 0.4094 0.4094
0.0706 0.7195 0.7195
0.0285 0.365 0
0.1443 0.2538 0.2538
0.0742 0.8923 1
0.0519 0.6716 0.6715
0.012 0.4858 0.4858
0.0245 0.2841 0.2906
0.0259 0.3135 0.2581
0.0716 0.7575 0.7575
0.0799 0.3196 0.5278
0.0127 0.4359 0.4334
0.0548 0.5541 0.55
0.075 0.2699 0.2698
0.0488 0.5551 1
0.0463 0.5089 0.6405
0.0702 0.3252 0.3252
0.0252 0.3059 0.6178
0.0236 0.2731 1
0.0756 0.7716 0.7694
0.0132 0.2616 0.2434
0.0898 0.3657 0.3653
0.0552 0.5588 0.5577
0.0283 0.7649 0.7649
0.0228 0.7318 0.8857
0.1443 0.2538 0.2538
0.0735 0.4551 1
0.0527 0.7772 1
0.0732 0.6091 0.6091
0.07 0.8765 1
0.0699 0.744 0.744
0.0791 0.7746 0.7744
0.0503 0.9371 1
0.0898 0.3657 0.3653
0.0749 0.8677 1
0.0227 0.2859 1
0.1413 0.5977 0.9238
0.0467 0.4463 0.4312
0.0735 0.4551 1
0.1413 0.5977 0.9238
0.0544 0.5525 0.5502
0.0525 0.6716 0.6715
0.0785 0.3165 0.3165
0.0789 0.4178 0.4172
0.075 0.2699 0.2698
0.0515 0.8401 1
0.0743 0.3265 0.3264
0.1443 0.2538 0.2538
0.0399 0.2853 0.5185
0.0134 0.3581 0
0.0381 0.4242 0.4242
0.0748 0.7678 0.7678
0.0464 0.2725 0.4251
0.0743 0.3265 0.3264
0.0731 0.716 0.7125
0.0128 0.5006 0.5006
0.0519 0.6716 0.6715
0.0767 0.7786 0.7786
0.07 0.8577 1
0.071 0.2816 0.8866
0.0754 0.2535 0.2535
0.0694 0.7476 0.7476
0.0767 0.7689 0.7689

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_163900 (Schistosoma mansoni), dopamine-beta-monooxygenase
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