Detailed view for Smp_010230.2

Basic information

TDR Targets ID: 287336
Schistosoma mansoni, guanine nucleotide-binding protein beta 1 4 (G protein beta1 4)
Source Database / ID:  GeneDB

pI: 5.85 | Length (AA): 340 | MW (Da): 37355 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0007165   signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 340 5kdo (B) 2 340 86.00 0 1 2.04726 -1.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127973)

Species Accession Gene Product
Arabidopsis thaliana AT4G34460   guanine nucleotide-binding protein subunit beta
Brugia malayi Bm1_54755   Guanine nucleotide-binding protein beta subunit 1, putative
Candida albicans CaO19.799   G-beta repeat protein similar to S. cerevisiae STE4 (YOR212W) beta subunit of heterotrimeric G protein coupled to pheromone rece
Candida albicans CaO19.8419   G-beta repeat protein similar to S. cerevisiae STE4 (YOR212W) beta subunit of heterotrimeric G protein coupled to pheromone rece
Caenorhabditis elegans CELE_F13D12.7   Protein GPB-1, isoform B
Dictyostelium discoideum DDB_G0277143   G protein b
Drosophila melanogaster Dmel_CG10545   G protein beta-subunit 13F
Echinococcus granulosus EgrG_000456200   guanine nucleotide binding protein subunit beta
Echinococcus granulosus EgrG_000200300   guanine nucleotide binding protein subunit
Echinococcus granulosus EgrG_000898100   F box protein 36
Entamoeba histolytica EHI_000240   hypothetical protein
Echinococcus multilocularis EmuJ_000898100   F box protein 36
Echinococcus multilocularis EmuJ_000200300   guanine nucleotide binding protein subunit
Echinococcus multilocularis EmuJ_000456200   guanine nucleotide binding protein subunit beta
Homo sapiens 59345   guanine nucleotide binding protein (G protein), beta polypeptide 4
Homo sapiens ENSG00000078369   guanine nucleotide binding protein (G protein), beta polypeptide 1
Homo sapiens ENSG00000172354   guanine nucleotide binding protein (G protein), beta polypeptide 2
Loa Loa (eye worm) LOAG_11417   hypothetical protein
Loa Loa (eye worm) LOAG_06405   GTP-binding regulatory protein beta chain
Mus musculus ENSMUSG00000029713   guanine nucleotide binding protein (G protein), beta 2
Mus musculus ENSMUSG00000029064   guanine nucleotide binding protein (G protein), beta 1
Mus musculus ENSMUSG00000027669   guanine nucleotide binding protein (G protein), beta 4
Oryza sativa 4333680   Os03g0669200
Saccharomyces cerevisiae YOR212W   Ste4p
Schistosoma japonicum Sjp_0128220   Guanine nucleotide-binding protein subunit beta-1, putative
Schistosoma japonicum Sjp_0121270   ko:K10312 F-box protein 36, putative
Schistosoma japonicum Sjp_0030040   Guanine nucleotide-binding protein subunit beta, putative
Schistosoma japonicum Sjp_0110650   Guanine nucleotide-binding protein subunit beta-1, putative
Schistosoma japonicum Sjp_0124130   Guanine nucleotide-binding protein subunit beta, putative
Schistosoma japonicum Sjp_0030060   Guanine nucleotide-binding protein subunit beta-1, putative
Schistosoma japonicum Sjp_0064530   ko:K07972 guanine nucleotide binding protein (G protein), beta, other, putative
Schistosoma mansoni Smp_010230.2   guanine nucleotide-binding protein beta 1 4 (G protein beta1 4)
Schistosoma mansoni Smp_063640   G-protein beta subunit
Schistosoma mansoni Smp_010230.1   guanine nucleotide-binding protein beta 1 4 (G protein beta1 4)
Schmidtea mediterranea mk4.004218.00   Guanine nucleotide-binding protein subunit beta-2
Schmidtea mediterranea mk4.005846.00   F-box only protein 36
Schmidtea mediterranea mk4.003090.00   Guanine nucleotide-binding protein subunit beta-1
Schmidtea mediterranea mk4.000101.05  
Schmidtea mediterranea mk4.000101.06   Guanine nucleotide-binding protein subunit beta-1
Schmidtea mediterranea mk4.005299.03   Guanine nucleotide-binding protein subunit beta-5
Schmidtea mediterranea mk4.020317.00   Guanine nucleotide-binding protein subunit beta-1
Schmidtea mediterranea mk4.043089.00   F-box only protein 36
Schmidtea mediterranea mk4.005653.00   Guanine nucleotide-binding protein subunit beta-1
Schmidtea mediterranea mk4.005653.02  
Schmidtea mediterranea mk4.004112.00   Guanine nucleotide-binding protein subunit beta-5
Schmidtea mediterranea mk4.005653.01   Guanine nucleotide-binding protein subunit beta-1
Schmidtea mediterranea mk4.042824.00   Guanine nucleotide-binding protein subunit beta-1
Schmidtea mediterranea mk4.010310.00   Guanine nucleotide-binding protein subunit beta-2

Essentiality

Smp_010230.2 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F13D12.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_F13D12.7 Caenorhabditis elegans slow growth wormbase
CELE_F13D12.7 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 4 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_010230.2 (Schistosoma mansoni), guanine nucleotide-binding protein beta 1 4 (G protein beta1 4)
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