Detailed view for Smp_157010

Basic information

TDR Targets ID: 287526
Schistosoma mansoni, titin
Source Database / ID:  GeneDB

pI: 6.1185 | Length (AA): 2668 | MW (Da): 292624 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00041   Fibronectin type III domain
PF07679   Immunoglobulin I-set domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 21 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 46 3lpw (A) 45 90 33.00 0.31 0.18 0.245267 0.33
120 442 4yfd (A) 199 511 28.00 0 1 0.273364 0.76
165 260 2cqv (A) 12 104 27.00 0.92 0.85 0.442282 -1.13
170 253 1wit (A) 12 92 35.00 0.00033 0.81 0.414784 -0.14
356 448 2crz (A) 14 97 46.00 0.000004 0.71 0.317158 -0.23
884 1190 5e55 (A) 598 893 28.00 0.00000017 1 0.182367 0.71
1098 1194 4o00 (A) 3 98 40.00 0.0000000021 1 0.660657 -1.66
1589 1837 5uv6 (A) 97 311 30.00 0.0000049 0.99 0.150628 0.8
1619 1718 2dm3 (A) 6 104 25.00 0 0.96 0.310681 -0.87
1622 2043 2jll (A) 301 676 27.00 0.000000000034 1 0.187471 1.09
1627 2040 5i99 (A) 413 785 27.00 0 1 0.256472 0.77
1741 1846 1igm (L) 10 113 18.00 0 0.18 0.0629301 -0.14
1755 1940 3mtr (A) 425 586 31.00 0.00000064 0.75 0.184015 0.39
1845 2084 4gh7 (B) 1176 1381 29.00 0.017 0.66 0.148255 0.26
1954 2066 2cuh (A) 5 105 26.00 0 0.52 0.171554 -0.87
1957 2043 1x4z (A) 18 103 36.00 0.0000011 0.99 0.501909 -0.72
2079 2473 3dmk (A) 138 479 31.00 0 1 0.172351 1.54
2175 2254 5xwu (B) 311 379 43.00 0.018 0.25 0.258285 0.45
2527 2650 1evt (C) 147 272 19.00 0.12 0.18 0.175877 0.02
2533 2651 1iil (G) 154 275 17.00 0.14 0.33 0.170003 -0.09
2541 2612 3m45 (A) 36 115 39.00 0.00094 0.9 0.461287 -0.96

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126738)

Species Accession Gene Product
Brugia malayi Bm1_26690   Prion-like-
Brugia malayi Bm1_54260   Prion-like-
Brugia malayi Bm1_02325   Immunoglobulin I-set domain containing protein
Brugia malayi Bm1_17625   muscle M-line assembly protein unc-89
Brugia malayi Bm1_39425   protein unc-22
Brugia malayi Bm1_55550   kettin
Brugia malayi Bm1_12515   Immunoglobulin I-set domain containing protein
Caenorhabditis elegans CELE_F54E2.4   Protein F54E2.4
Caenorhabditis elegans CELE_C09D1.1   Protein UNC-89, isoform B
Caenorhabditis elegans CELE_F15G9.4   Protein HIM-4, isoform D
Caenorhabditis elegans CELE_F54E2.3   Protein KETN-1, isoform C
Caenorhabditis elegans CELE_ZK617.1   Protein UNC-22, isoform F
Caenorhabditis elegans CELE_F15G9.4a   Protein HIM-4, isoform C
Dictyostelium discoideum DDB_G0294611   hypothetical protein
Drosophila melanogaster Dmel_CG1915   sallimus
Drosophila melanogaster Dmel_CG42768   Muscle-specific protein 300 kDa
Drosophila melanogaster Dmel_CG32019   bent
Drosophila melanogaster Dmel_CG33519   CG33519 gene product from transcript CG33519-RH
Echinococcus granulosus EgrG_000597700   titin
Echinococcus granulosus EgrG_000952600   titin
Echinococcus granulosus EgrG_000422350   hemicentin 1
Echinococcus granulosus EgrG_000226000   titin
Echinococcus multilocularis EmuJ_000422400   hemicentin 1
Echinococcus multilocularis EmuJ_000597700   titin
Echinococcus multilocularis EmuJ_000226000   titin
Echinococcus multilocularis EmuJ_000952600  
Echinococcus multilocularis EmuJ_000039200   titin
Echinococcus multilocularis EmuJ_000422300   hemicentin 1
Homo sapiens 101930376   hemicentin-2-like
Homo sapiens ENSG00000143341   hemicentin 1
Homo sapiens ENSG00000124006   obscurin-like 1
Homo sapiens ENSG00000155657   titin
Homo sapiens ENSG00000148357   hemicentin 2
Homo sapiens ENSG00000072195   SPEG complex locus
Homo sapiens ENSG00000154358   obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Homo sapiens ENSG00000072195   CAVP-target protein-like
Homo sapiens 101929220   WAS/WASL-interacting protein family member 1-like
Loa Loa (eye worm) LOAG_01020   hypothetical protein
Loa Loa (eye worm) LOAG_04436   hypothetical protein
Loa Loa (eye worm) LOAG_01021   hypothetical protein
Loa Loa (eye worm) LOAG_15451   hypothetical protein
Loa Loa (eye worm) LOAG_04544   hypothetical protein
Loa Loa (eye worm) LOAG_01925   CAMK/MLCK protein kinase
Loa Loa (eye worm) LOAG_05722   hypothetical protein
Loa Loa (eye worm) LOAG_15557   hypothetical protein
Loa Loa (eye worm) LOAG_02065   hypothetical protein
Loa Loa (eye worm) LOAG_09000   projectin
Loa Loa (eye worm) LOAG_04438   hypothetical protein
Loa Loa (eye worm) LOAG_07554   hypothetical protein
Loa Loa (eye worm) LOAG_07292   hypothetical protein
Loa Loa (eye worm) LOAG_04081   hypothetical protein
Loa Loa (eye worm) LOAG_02063   hypothetical protein
Loa Loa (eye worm) LOAG_02064   hypothetical protein
Mus musculus ENSMUSG00000061462   obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Mus musculus ENSMUSG00000055632   hemicentin 2
Mus musculus ENSMUSG00000066842   hemicentin 1
Mus musculus 102641264   titin-like
Mus musculus ENSMUSG00000051747   titin
Mus musculus ENSMUSG00000026211   obscurin-like 1
Mus musculus ENSMUSG00000026207   SPEG complex locus
Neospora caninum NCLIV_040610   Virulent strain associated lipoprotein, related
Onchocerca volvulus OVOC3498   Putative titin
Onchocerca volvulus OVOC7179  
Schistosoma japonicum Sjp_0109770   IPR013098,Immunoglobulin I-set,domain-containing
Schistosoma japonicum Sjp_0134570   IPR000215,Proteinase inhibitor I4, serpin,domain-containing
Schistosoma japonicum Sjp_0208700   ko:K00907 myosin-light-chain kinase [EC2.7.11.18], putative
Schistosoma japonicum Sjp_0098070   Titin, putative
Schistosoma japonicum Sjp_0115810   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0056280   ko:K06841 semaphorin 5, putative
Schistosoma japonicum Sjp_0094680   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0011210   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0097290   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0308120   IPR007110,Immunoglobulin-like,domain-containing
Schistosoma japonicum Sjp_0097890   ko:K00907 myosin-light-chain kinase [EC2.7.11.18], putative
Schistosoma japonicum Sjp_0094690   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0104450   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0088120   IPR013098,Immunoglobulin I-set;IPR003599,Immunoglobulin subtype;IPR007110,Immunoglobulin-like,domain-containing
Schistosoma mansoni Smp_126240   titin
Schistosoma mansoni Smp_157010   titin
Schistosoma mansoni Smp_105020   titin
Schistosoma mansoni Smp_157020   hemicentin
Schistosoma mansoni Smp_163920   titin
Schmidtea mediterranea mk4.000677.06  
Schmidtea mediterranea mk4.003018.00  
Schmidtea mediterranea mk4.000643.04  
Schmidtea mediterranea mk4.001029.10  
Schmidtea mediterranea mk4.000677.07  
Schmidtea mediterranea mk4.030799.00  
Schmidtea mediterranea mk4.000677.05  
Schmidtea mediterranea mk4.000643.06  
Schmidtea mediterranea mk4.000677.08   Twitchin
Schmidtea mediterranea mk4.001095.04  
Schmidtea mediterranea mk4.001029.07   Putative titin
Schmidtea mediterranea mk4.000677.04  
Schmidtea mediterranea mk4.007460.00  
Schmidtea mediterranea mk4.000677.03  
Schmidtea mediterranea mk4.001029.09  
Schmidtea mediterranea mk4.008079.00  
Schmidtea mediterranea mk4.000643.03  
Schmidtea mediterranea mk4.020649.02  
Schmidtea mediterranea mk4.001519.04  
Schmidtea mediterranea mk4.007626.00   Kettin/titin-related protein
Schmidtea mediterranea mk4.001252.09  
Schmidtea mediterranea mk4.003939.00  
Schmidtea mediterranea mk4.006111.00  
Schmidtea mediterranea mk4.001519.01   Putative titin
Schmidtea mediterranea mk4.014446.03  
Schmidtea mediterranea mk4.001029.11  
Schmidtea mediterranea mk4.000643.05   Putative titin

Essentiality

Smp_157010 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F54E2.3 Caenorhabditis elegans slow growth wormbase
CELE_ZK617.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZK617.1 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0006 1 1
0.045 0.3044 0.4721
0.0106 0.4418 0.4785
0.0414 0.6115 0.6115
0.0348 0.3967 0.3967
0.0178 0.5983 0.5983
0.0461 0.2819 0.2813
0.0089 0.442 0.6887
0.0092 0.3268 0.381
0.0322 0.4001 0.4676
0.0085 0.4509 0.4509
0.0084 0.4625 0.4625
0.0374 0.7576 0.7576
0.013 0.8813 0.9078
0.0348 0.3967 0.3967
0.0251 0.7407 0.7375
0.0216 0.706 0.706
0.0111 0.334 1
0.012 0.3366 0.3536
0.0204 0.2615 0.2789
0.012 0.7362 0.7362
0.0116 0.2785 0.3385
0.0177 0.292 0.2232
0.0074 0.2516 0.2551
0.00855091 0.284971 0.327511
0.0047 0.445 0.506
0.0255 0.706 0.706
0.0348 0.3967 0.3967
0.0042 0.415 0
0.0236 0.3002 0.3447
0.0312 0.5397 0
0.0016 1 0.5
0.0089 0.442 0.6887
0.0156 0.6042 0.6042
0.0212 0.4381 0.4877
0.0348 0.3967 0.3967
0.045 0.3044 0.4721
0.0132 0.2972 0.7394
0.0403 0.706 0.706
0.0251 0.7407 0.7375
0.045 0.3044 0.4721
0.0313 0.5953 0.7027
0.0488 0.3798 0.3794
0.0176 0.3962 0.4355
0.0343 0.706 0.706
0.0209 0.4772 0.5459
0.0305 0.5153 0.5833
0.0334 0.4633 0.4633
0.0475 0.706 0.706
0.022 0.257 0.6919
0.0084 0.6788 1
0.018 0.3131 0.3233
0.0336 0.3462 0.4786
0.0106 0.3726 0.3742
0.0083 1 0.5
0.012 0.7362 0.7362
0.0006 1 1
0.037 0.706 0.706
0.0255 0.706 0.706
0.0461 0.2819 0.2813
0.014 0.4544 0.4749
0.0156 0.6042 0.6042
0.0034 0.2581 0.2581
0.0078 0.2971 0.4601
0.017 0.2614 0.6652
0.0334 0.4633 0.4633
0.0104 0.8804 1
0.0089 0.4623 0.4623
0.00855091 0.284971 0.327511
0.0347 0.7058 0.7058
0.045 0.3044 0.4721
0.043 0.5151 0.5151
0.0223 0.4639 0.4639
0.0209 0.4772 0.5459
0.0133 0.3628 0.4348
0.0378 0.586 0.586
0.0378 0.586 0.586
0.0272 0.4658 0.5345
0.0086 0.3597 0.3597
0.0009 0.5 0.5
0.02 0.7068 0.706
0.0414 0.6115 0.6115
0.0272 0.706 0.706
0.0326 0.5076 0.5759
0.0152 0.2836 0.3534
0.0164 0.7647 0.7647
0.0189 0.4064 0.4423
0.0184 0.706 0.706
0.0348 0.3967 0.3967
0.022 0.257 0.6919
0.0338 0.7566 0.752
0.045 0.3044 0.4721
0.0146 0.4001 0.4676
0.0038 0.4237 0
0.0329 0.4001 0.4676
0.0008 1 1
0.045 0.3044 0.4721
0.0088 1 1
0.0088 1 1
0.00855091 0.284971 0.327511
0.0071 0.8198 0.9055
0.0008 1 1
0.0461 0.2819 0.2813
0.0154 0.5295 0.5602
0.0006 1 1
0.0471 0.341 0.3405
0.0114 0.6153 0.3459
0.0374 0.7576 0.7576
0.045 0.3044 0.4721
0.0193 0.3374 0.3467
0.0203 0.2854 0.3447
0.0093 0.3031 0.3073
0.0461 0.2819 0.2813
0.0266 0.2855 0.5677
0.0178 0.5983 0.5983
0.008 0.4641 0
0.0301 0.2854 0.3447
0.0448 0.7636 0.7636
0.0305 0.4857 0.5543
0.045 0.3044 0.4721
0.0271 0.3613 0.7611
0.0351 0.6072 0
0.0223 0.4639 0.4639
0.0008 1 1
0.0177 0.2559 0.3069
0.0084 0.6788 1
0.0471 0.341 0.3405
0.0155 0.3568 0.706
0.0095 0.4151 0.4151
0.0116 0.6967 0.6967
0.0129 0.3276 0.3276
0.0212 0.4381 0.4877
0.0329 0.5062 0.5745
0.0343 0.706 0.706

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_157010 (Schistosoma mansoni), titin
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