Detailed view for Smp_140700

Basic information

TDR Targets ID: 287932
Schistosoma mansoni, serine/threonine protein kinase
Source Database / ID:  GeneDB

pI: 8.7753 | Length (AA): 577 | MW (Da): 64576 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004672   protein kinase activity  
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004707   MAP kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

FoxO signaling pathway (KEGG)
Wnt signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
102 577 5t6a (A) 45 499 22.00 0 0.71 0.826857 0.57
108 434 5byz (A) 55 362 44.00 0 1 1.02622 -0.18
108 559 5iso (A) 16 463 21.00 0 1 0.848262 1.03
122 419 1cm8 (A) 41 313 41.00 0 1 0.940964 -0.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132829)

Species Accession Gene Product
Brugia malayi Bm1_00130   Protein kinase domain containing protein
Caenorhabditis elegans CELE_W06F12.1   Protein LIT-1, isoform D
Drosophila melanogaster Dmel_CG7892   nemo
Echinococcus granulosus EgrG_001020300   serine:threonine protein kinase NLK
Echinococcus multilocularis EmuJ_001020300   serine:threonine protein kinase NLK
Homo sapiens ENSG00000087095   nemo-like kinase
Loa Loa (eye worm) LOAG_12277   CMGC/MAPK/NMO protein kinase
Loa Loa (eye worm) LOAG_15847   hypothetical protein
Mus musculus ENSMUSG00000017376   nemo like kinase
Schistosoma japonicum Sjp_0066980   Serine/threonine kinase NLK, putative
Schistosoma mansoni Smp_140700   serine/threonine protein kinase
Schmidtea mediterranea mk4.001450.12   Serine/threonine kinase NLK

Essentiality

Smp_140700 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_W06F12.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_W06F12.1 Caenorhabditis elegans larval lethal wormbase
CELE_W06F12.1 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens nemo-like kinase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 33.8% 311 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 28.1% 203 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 23.6% 276 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 39.7% 194 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 34.0% 312 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 39.0% 305 aa Compounds References
Patiria pectinifera Cdc2 300 aa 32.6% 313 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 38.6% 334 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 35.4% 314 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0059 1 1
0.0003 0.5 0.5
0.0033 1 1
0.0059 1 1
0.0007 0.5 0.5
0.0007 0.5 0.5
0.0067 0.5 0.5
0.0062 0.6935 0.7231
0.0037 1 0.5
0.0026 0.5 0.5
0.0039 0.5 0.5
0.0091 1 1
0.0063 1 1
0.0039 0.5 0.5
0.0011 1 1
0.0018 0.5 0.5
0.0066 0.3101 0.9479
0.0022 0.5 0.5
0.0036 0.5 0.5
0.0012 0.5 0.5
0.0059 1 1
0.0081 0.5 0.5
0.0033 0.5 0.5
0.0008 0.5 0.5
0.0063 0.7244 0
0.0056 1 1
0.0069 0.3067 0.3067
0.0016 0.5 0.5
0.0029 0.5 0.5
0.0004 0.5 0.5
0.0023 0.5 0.5
0.0032 0.5 0.5
0.0012 0.5 0.5
0.0064 0.3377 0.9531
0.0032 0.5 0.5
0.0012 0.5 0.5
0.0016 0.5 0.5
0.0098 0.3242 0.2614
0.0081 1 1
0.0042 0.5 0.5
0.0061 0.6883 0.6656
0.0027 1 1
0.0007 0.5 0.5
0.0088 0.4477 0.6337
0.0092 1 1
0.0039 0.9485 1
0.0093 0.8828 0

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_140700 (Schistosoma mansoni), serine/threonine protein kinase
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