Detailed view for Smp_050380

Basic information

TDR Targets ID: 288147
Schistosoma mansoni, protein kinase
Source Database / ID:  GeneDB

pI: 8.1978 | Length (AA): 1793 | MW (Da): 201709 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

Ubiquitin mediated proteolysis (KEGG)

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
128 511 4k6j (A) 670 1108 12.00 0 0.02 0.224666 -0.08
1201 1635 5mo4 (A) 122 527 22.00 0 1 0.26811 0.5
1288 1665 4wnk (A) 110 512 22.00 0 1 0.25682 0.26
1337 1760 4ysj (A) 9 440 23.00 0 1 0.386975 0.28
1351 1639 1u5q (A) 13 300 29.00 0 1 0.329182 -0.56
1355 1615 6e2m (B) 676 933 39.00 0 1 0.516266 -0.28
1358 1668 6bg2 (C) 356 665 22.00 0 1 0.261452 -0.26
1361 1712 3v5w (A) 190 534 28.00 0 1 0.264319 -0.06
1362 1628 4b6l (A) 62 322 31.00 0 1 0.368912 -0.58
1613 1704 4rwt (D) 401 492 34.00 0.39 0.11 0.0770107 2.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128416)

Species Accession Gene Product
Arabidopsis thaliana AT1G09000   mitogen-activated protein kinase kinase kinase ANP1
Arabidopsis thaliana AT3G06030   mitogen-activated protein kinase kinase kinase 3
Arabidopsis thaliana AT1G54960   NPK1-related protein kinase 2
Brugia malayi Bm1_11350   Protein kinase domain containing protein
Candida albicans CaO19.8464   likely MAPKKK similar to S. cerevisiae STE11 (YLR362W) MAPKKK of the pheromone response pathway
Candida albicans CaO19.844   likely MAPKKK similar to S. cerevisiae STE11 (YLR362W) MAPKKK of the pheromone response pathway
Dictyostelium discoideum DDB_G0283265   F-box-containing protein
Echinococcus granulosus EgrG_000389600   mitogen activated protein kinase kinase kinase
Echinococcus multilocularis EmuJ_000389600   mitogen activated protein kinase kinase kinase
Homo sapiens ENSG00000169967   mitogen-activated protein kinase kinase kinase 2
Homo sapiens ENSG00000198909   mitogen-activated protein kinase kinase kinase 3
Homo sapiens ENSG00000176601   mitogen-activated protein kinase kinase kinase 19
Loa Loa (eye worm) LOAG_05805   STE/STE11/MEKK2 protein kinase
Mus musculus ENSMUSG00000024383   mitogen-activated protein kinase kinase kinase 2
Mus musculus ENSMUSG00000020700   mitogen-activated protein kinase kinase kinase 3
Mus musculus ENSMUSG00000051590   mitogen-activated protein kinase kinase kinase 19
Oryza sativa 4345595   Os08g0421800
Oryza sativa 4346940   Os09g0383300
Onchocerca volvulus OVOC11755  
Saccharomyces cerevisiae YLR362W   Ste11p
Schistosoma japonicum Sjp_0018650   ko:K04416 mitogen-activated protein kinase kinase kinase 1, putative
Schistosoma mansoni Smp_050380   protein kinase
Schmidtea mediterranea mk4.012560.04   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.003911.08   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.000848.07   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.004421.00  
Schmidtea mediterranea mk4.001978.02   Serine/threonine-protein kinase PAK mbt
Schmidtea mediterranea mk4.009148.02   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.000265.07   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.000517.02   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.005767.00  
Schmidtea mediterranea mk4.001734.00  
Schmidtea mediterranea mk4.000652.08   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.017614.00  
Schmidtea mediterranea mk4.000165.17  
Schmidtea mediterranea mk4.000049.07   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.001445.01   Mitogen-activated protein kinase kinase kinase 19
Schmidtea mediterranea mk4.000848.08  
Schmidtea mediterranea mk4.002610.01  
Schmidtea mediterranea mk4.002795.01  
Schmidtea mediterranea mk4.001800.02   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.006618.00  
Schmidtea mediterranea mk4.001330.04   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.000239.01   Serine/threonine-protein kinase PAK mbt
Schmidtea mediterranea mk4.001605.00   Serine/threonine-protein kinase flr-4
Schmidtea mediterranea mk4.006212.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens mitogen-activated protein kinase kinase kinase 3 Compounds References
Homo sapiens mitogen-activated protein kinase kinase kinase 19 Compounds References
Homo sapiens mitogen-activated protein kinase kinase kinase 2 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 29.9% 284 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 27.7% 282 aa Compounds References
Patiria pectinifera Cdc2 300 aa 28.6% 269 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 25.9% 278 aa Compounds References
Zea mays CaM kinase I alpha 492 aa 24.0% 425 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0008 0.5 0.5
0.0063 0.7244 0
0.0056 1 1
0.0016 0.5 0.5
0.0069 0.3067 0.3067
0.0029 0.5 0.5
0.0022 0.5 0.5
0.0059 1 1
0.0036 0.5 0.5
0.0012 0.5 0.5
0.0081 0.5 0.5
0.0033 0.5 0.5
0.0061 0.6883 0.6656
0.0027 1 1
0.0007 0.5 0.5
0.0088 0.4477 0.6337
0.0092 1 1
0.0039 0.9485 1
0.0093 0.8828 0
0.0023 0.5 0.5
0.0004 0.5 0.5
0.0032 0.5 0.5
0.0012 0.5 0.5
0.0032 0.5 0.5
0.0064 0.3377 0.9531
0.0012 0.5 0.5
0.0016 0.5 0.5
0.0098 0.3242 0.2614
0.0081 1 1
0.0042 0.5 0.5
0.0067 0.5 0.5
0.0062 0.6935 0.7231
0.0059 1 1
0.0003 0.5 0.5
0.0033 1 1
0.0059 1 1
0.0007 0.5 0.5
0.0007 0.5 0.5
0.0011 1 1
0.0039 0.5 0.5
0.0018 0.5 0.5
0.0066 0.3101 0.9479
0.0037 1 0.5
0.0026 0.5 0.5
0.0039 0.5 0.5
0.0091 1 1
0.0063 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_050380 (Schistosoma mansoni), protein kinase
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