Detailed view for PF3D7_1458000

Basic information

TDR Targets ID: 2883
Plasmodium falciparum, cysteine proteinase falcipain 1

Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.6118 | Length (AA): 569 | MW (Da): 66914 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00112   Papain family cysteine protease
PF08246   Cathepsin propeptide inhibitor domain (I29)

Gene Ontology

Mouse over links to read term descriptions.
GO:0042540   hemoglobin catabolic process  
GO:0008234   cysteine-type peptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
215 568 1pci (A) 12 214 34.00 0 1 0.87 0.16
333 568 2act () 1 216 32.00 0 1 0.57 -0.41
19 187 4uos (A) 3 177 16.00 0.0047 0.04 0.525812 -1.39
208 568 4qrv (A) 5 317 31.00 0 1 0.722746 0.8
221 287 3f75 (P) 113 177 31.00 0.14 0.57 0.49835 -0.55
333 567 1fh0 (A) 1 218 39.00 0 1 0.767605 -0.46
334 567 1vsn (A) 2 209 42.00 0 1 0.664848 0.45
337 569 3bwk (A) 31 249 38.00 0.00000000038 1 0.83229 -0.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, merozoite, sporozoite, early ring, early trophozoite, late ring, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 24 hs, gametocyte, early schizont, late schizont, late trophozoite, Oocyst, Sporozoite. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Female Gametocyte, Male Gametocyte. Otto TD Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 32 hs. Otto TD
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_141501)

Species Accession Gene Product
Arabidopsis thaliana AT1G09850   papain-like cysteine peptidase
Drosophila melanogaster Dmel_CG6347   CG6347 gene product from transcript CG6347-RA
Drosophila melanogaster Dmel_CG4847   CG4847 gene product from transcript CG4847-RA
Oryza sativa 4339265   Os05g0508300
Plasmodium berghei PBANKA_1321700   berghepain-1
Plasmodium falciparum PF3D7_1458000   cysteine proteinase falcipain 1
Plasmodium knowlesi PKNH_1223800   knowpain-1
Plasmodium vivax PVX_240290   unspecified product
Plasmodium vivax PVX_117565   vivapain-1
Plasmodium vivax PVX_195290   unspecified product
Plasmodium yoelii PY00109   cysteine proteinase precursor
Schmidtea mediterranea mk4.000315.18  

Essentiality

PF3D7_1458000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1321700 Plasmodium berghei Slow plasmo
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) decreased time (PATO:0000716) multi-cellular organism (CARO:0000012) oocyst (PLO:0002) inferred from loss-of-function mutant phenotype (ECO:0000016) Plasmodium falciparum No drug identifiers listed for this gene.
Annotator: saralph@unimelb.edu.au. Comment: 012/Mar/09. References: 15225318
growth (GO:0040007) decreased time (PATO:0000716) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) inferred from RNAi experiment (ECO:0000019) Plasmodium falciparum No drug identifiers listed for this gene.
Annotator: saralph@unimelb.edu.au. Comment: 012/Mar/09. References: 12207693
cell morphogenesis (GO:0000902) abnormal (PATO:0000460) bloodstream stage (PLO:0040) inferred from RNAi experiment (ECO:0000019) Plasmodium falciparum No drug identifiers listed for this gene.
Annotator: saralph@unimelb.edu.au. Comment: 012/Mar/09. References: 12207693
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum 81384   576750  
Annotator: saralph@unimelb.edu.au. Comment: Drug: YA29-Eps(S,S). . References: 12207693 12471262 15225318 16041608

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3


Known modulators for this target

Compound Source Reference
ChEMBL23 References
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Curated by TDRTargets References
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Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Cathepsin K 329 aa 32.8% 348 aa Compounds References
Canis familiaris Cathepsin K 330 aa 33.0% 348 aa Compounds References
Rattus norvegicus Cathepsin B 339 aa 22.6% 283 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 29.1% 343 aa Compounds References
Rattus norvegicus Cathepsin S 330 aa 29.9% 354 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 29.4% 343 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 29.1% 343 aa Compounds References
Rattus norvegicus Cathepsin K 329 aa 33.1% 350 aa Compounds References
Rattus norvegicus Cathepsin L 334 aa 29.8% 359 aa Compounds References
Dermatophagoides pteronyssinus Peptidase 1 320 aa 25.2% 337 aa Compounds References
Capra hircus Cathepsin H 335 aa 30.7% 361 aa Compounds References
Leishmania donovani Cysteine protease 394 aa 28.7% 341 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 29.1% 343 aa Compounds References
Carica papaya Papain 345 aa 30.6% 376 aa Compounds References
Capra hircus Cathepsin B 335 aa 22.9% 297 aa Compounds References
Leishmania major cathepsin L-like protease 348 aa 28.6% 343 aa Compounds References
Bos taurus Cathepsin L 334 aa 29.5% 359 aa Compounds References
Leishmania major cysteine peptidase A (CPA) 354 aa 26.5% 347 aa Compounds References

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.1156 0.3317 0.4054
0.0396 0.3677 0.4054
0.0267 0.3334 0
0.048 0.2568 0
0.0164 0.2757 0
0.0248 0.4054 0.4054
0.0448 0.5074 0.5074
0.0088 0.4473 0.4473
0.0925 0.5133 0.4054
0.0071 0.2927 0.4054
0.0437 0.4622 1
0.009 0.3467 0
0.0593 0.5137 0.5126
0.0176 0.4791 0.4996
0.0059 0.4687 0.4594
0.1245 0.2796 0.4107
0.0698 0.2664 0.5225
0.0569 0.5076 0.5069
0.0174 0.2529 0.4054
0.0591343 0.51384 0.513019
0.0226 0.2928 1
0.0262 0.3817 0.4054
0.0544 0.5046 0.4054
0.0285 0.4915 0.4054
0.0704 0.2766 0.4054
0.1048 0.2564 0.5306
0.0288 0.4054 0.4054
0.0036 0.3727 0.2982
0.0112 0.4548 1
0.0275 0.2676 0.4936
0.0267 0.4519 0.4054
0.0381 0.2532 0.5228
0.0334 0.441 0.4054
0.0175 0.2757 0
0.0815 0.3361 0.5077
0.0569 0.4881 0.5075
0.0282 0.3067 0.5012
0.0189 0.51 0.4987
0.0398 0.4186 0.7585
0.1114 0.2755 0.529
0.0224 0.4054 0.4054
0.0827 0.2953 0.4981
0.0634 0.5076 0.507
0.0484 0.3619 0.528
0.0569934 0.275676 0
0.0383 0.2735 0.5214
0.1114 0.2755 0.529
0.0432 0.5089 0.5069
0.0355 0.2636 0.5334
0.0154 0.3483 0.5069
0.0287 0.4379 0.4054
0.1306 0.2771 0.5334
0.0194 0.3257 0
0.0116 0.2909 1
0.045 0.3944 0.3927
0.0657 0.337 0.4524
0.014 0.2823 0.4821
0.0584 0.2706 1
0.0434 0.4139 0.4054
0.05 0.252 0.5334
0.0217 0.2985 1
0.042 0.4054 0.4054
0.0333 0.4068 1
0.053 0.3208 0.4054
0.0506 0.2719 0.4054
0.125994 0.422253 0.538898
0.0219 0.2701 1
0.0141 0.4054 0.4054
0.0226 0.2928 1
0.0289 0.3511 0.5108
0.0647 0.5102 0.5065
0.0042 0.2757 0
0.0303 0.3261 0.5055
0.0099 0.2504 0.4292
0.067 0.4287 0.4654
0.0141 0.4602 0.4054
0.018 0.376 0
0.0329 0.3993 0
0.0385 0.2781 0.5155
0.059 0.3088 0.4054
0.1282 0.2563 0.5407
0.0035 0.2757 0
0.0824 0.4193 0.5721
0.039 0.4054 0.4054
0.0134 0.4936 0.4054
0.0108 0.6536 1
0.0519 0.5067 0.504
0.0383 0.2822 0
0.0399 0.6187 1
0.0175 0.4983 0.4983
0.0104 0.4054 0.4054
0.0556 0.2602 0.4054
0.0246 0.2517 0.5284
0.0098 0.2747 0.439
0.0367 0.3536 0.5176
0.0081 0.4054 0.4054
0.0564 0.5082 0.5027
0.0208 0.518 1
0.051 0.2973 0.5269
0.0028 0.2757 0.2498
0.0433 0.2637 0
0.0039 0.2923 0
0.1368 0.2776 0.5387
0.0647 0.5102 0.5065
0.0045 0.3451 0
0.0676 0.9715 1
0.0489 0.4975 0.4681
0.0703 0.5031 0.4054
0.0223 0.2656 1
0.0189 0.4284 0.4207
0.0333 0.5044 0.5044
0.0235 0.2893 1
0.0117 0.9248 1
0.0124 0.4054 0.4054
0.0584 0.2706 1
0.0318 0.4832 0.4987
0.0462 0.5018 0.5018
0.0038 0.4346 0.4054
0.0124 0.4051 1
0.0048 0.2757 0
0.0369 0.3567 0.8235
0.0429 0.4054 0.4054
0.0141 0.4689 0.4421
0.0373 0.3602 0.4054
0.1145 0.2644 0.5379
0.0716 0.3134 0.5144
0.1424 0.543 0.5417
0.3132 0.4569 0.5375
0.0224 0.9284 1
0.0608 0.5101 0.5101
0.0121 0.424 0.4054
0.0121 0.4054 0.4054
0.0182 0.2737 0.4054
0.0011 0.2757 0
0.0093 0.4194 0.4194
0.1114 0.2755 0.529
0.0489 0.4975 0.4681
0.0202 0.2513 1
0.0328 0.2605 1
0.06 0.5024 0.5024
0.0351 0.4891 0.4842
0.0039 0.4841 0.4841
0.0529 0.2614 0.5339
0.1282 0.2563 0.5407
0.1308 0.253 0.5417
0.0569 0.5076 0.5069
0.037 0.2521 0.5034
0.0297 0.5037 0.4664
0.0755 0.2754 0.541
0.0703 0.5031 0.4054
0.0337 0.4131 1
0.0833 0.5193 0.5131
0.02 0.4504 0.421
0.0604 0.2722 0.5177
0.0356 0.2541 0
0.0042 0.4083 0.4054
0.0566 0.3328 0.507
0.0312 0.3475 0.4922
0.1205 0.3279 0
0.0109 0.3648 0.4497
0.0107 0.3193 1
0.0566 0.2757 0
0.0275 0.2676 0.4936
0.0627 0.3975 0.5034
0.0135 0.4054 0.4054
0.0286 0.2584 0.5189
0.0058 0.2757 0
0.0292 0.3045 0.5071
0.0042 0.2757 0
0.0336 0.4198 1
0.0255 0.2866 0.5165
0.0244 0.2832 0.4583
0.0344 0.3295 0.5198
0.0305 0.2518 0
0.1137 0.3284 0.5313
0.1287 0.4385 0.4054
0.0485 0.2629 0
0.0468 0.5013 0.5013
0.0355 0.2636 0.5334
0.0601382 0.502154 0.405405
0.0224 0.2757 0
0.045 0.3944 0.3927
0.0568 0.2744 1
0.0415 0.2586 0.5019
0.0282 0.2767 0.482
0.0112 0.3526 1
0.0817 0.5239 0.4173
0.0268 0.4054 0.4054
0.0181 0.3056 0
0.0027 0.2913 0
0.0344 0.2738 0.5225
0.039 0.4054 0.4054
0.0292 0.2978 0.5008
0.0134 0.3516 1
0.0321 0.3614 0.4054
0.3132 0.4569 0.5375
0.0452 0.2683 0
0.0967638 0.341487 0.516571
0.0228 0.3208 0.4556
0.0138 0.3361 0.4054
0.0246 0.5055 0.4929
0.0139 0.4054 0.4054
0.023 0.8089 1
0.0734 0.4086 0.5583
0.0097 0.4054 0.4054
0.0125 0.2567 0.4054
0.0717 0.4051 0.5082
0.0489 0.4975 0.4681
0.0028 0.4054 0.4054
0.0519 0.5067 0.504
0.045 0.3944 0.3927
0.0405 0.4054 0.4054
0.0827 0.3354 0.532
0.0383 0.2735 0.5214
0.0353 0.4942 0.4054
0.0217 0.2771 1
0.012 0.2961 0
0.0257 0.2872 0.4054
0.1472 0.2676 0.5513
0.0216 0.2607 0.4054
0.0579 0.5068 0.4934
0.0288 0.4054 0.4054
0.0524 0.5128 0.5117
0.0423 0.2634 0.4054
0.0336 0.3732 0.4054
0.035 0.2612 0.4054
0.0558 0.5082 0.5031
0.0878 0.4674 0.4054
0.0512 0.2899 0.1868
0.0519 0.5067 0.504
0.0762 0.2787 0.5368
0.1025 0.2644 0.4054
0.0369 0.2509 0.506
0.0158 0.4054 0.4054
0.0502 0.5117 0.5048
0.0436 0.4744 0.4054
0.024 0.4213 0.42
0.0195 0.4787 0.4602
0.1085 0.3337 0.5106
0.0111 0.2559 1
0.0011 0.2757 0
0.0176 0.2757 0
0.0327 0.3187 0.5083
0.0014 0.2757 0
0.0409 0.5012 0.4054
0.0279 0.2886 0.4854
0.0478 0.3327 0.4054
0.0134 0.4054 0.4054
0.011 0.8209 1
0.0432 0.3152 0.4528
0.0684 0.4983 0.4365
0.1588 0.2816 0.5439
0.0601382 0.502154 0.405405
0.0591343 0.51384 0.513019
0.0123 0.2757 0
0.0386 0.2819 0
0.0141 0.4301 0.4054
0.0446 0.4753 0.5014
0.0827 0.3354 0.532
0.0334 0.3983 0.4994
0.0356 0.496 0.4142
0.0291 0.3474 0
0.0726 0.5134 0.5113
0.0447 0.2765 1
0.0217 0.286 0
0.0614 0.2968 0.4054
0.0014 0.2757 0
0.037 0.2521 0.5034
0.0716 0.3323 0.5068
0.038 0.4916 0.4916
0.1057 0.3287 0.5313
0.0497 0.2748 0.4054
0.0507 0.3373 0
0.0341 0.2997 0.527
0.0528 0.508 0.5027
0.0067 0.3432 0
0.0324 0.35 0.5057
0.039 0.4054 0.4054
0.06 0.5024 0.5024
0.1337 0.3311 0.5058
0.045 0.3944 0.3927
0.0314 0.4529 0.4054
0.0327 0.3027 0.4054
0.1282 0.2563 0.5407
0.0297 0.2926 0.4979
0.013 0.4763 0.4224
0.0059 0.2795 0.4374
0.0151425 0.261895 0
0.0299 0.4679 0.4679
0.0369 0.2509 0.506
0.0492 0.2811 0
0.0115 0.2891 0.4674
0.0279 0.3196 0.3571
0.0111 0.3413 0.3413
0.0835 0.2934 0.5192
0.0535 0.4054 0.4054
0.0265 0.269 0.4722
0.1173 0.5336 0.5336
0.0058 0.4299 0.4241
0.0298 0.3403 0.5165
0.0014 0.2757 0
0.1859 0.3086 0.5268
0.0084 0.4453 0.4453
0.0269 0.2985 0.4596
0.0627 0.3975 0.5034
0.0422 0.2757 0
0.0319 0.3345 0.4054
0.0688 0.273 1
0.0185 0.4054 0.4054
0.0526 0.4054 0.4054
0.0319 0.2729 0.51
0.0553 0.2994 0.4054
0.035 0.5064 0.4912
0.0047 0.284 0.4054
0.0757 0.2709 0.4054
0.0179 0.3641 0.5048
0.0633 0.2645 0.5314
0.031 0.2831 0
0.0465 0.6026 1
0.0328 0.3663 0.7793
0.0302 0.4828 0.4054
0.0474 0.2526 0
0.0208 0.4054 0.4054
0.0388 0.2958 0.5256
0.0202 0.3546 0.4985
0.0493 0.4945 0.5175
0.0359 0.5131 0.513
0.0261 0.3713 0.4054
0.0478 0.3327 0.4054
0.1104 0.2725 0.5452
0.037 0.4729 0.4054
0.0708 0.4383 0.5077
0.0737501 0.499194 0.495196
0.0221 0.4267 0.9875
0.0293 0.2757 0
0.0458 0.2552 1
0.0446 0.265 0
0.0715 0.5017 0.4054
0.0982 0.5105 0.5085
0.0128 0.2757 0
0.0766 0.2549 0.5357
0.0084 0.4453 0.4453
0.0297 0.4585 0.4054
0.0423 0.3464 0
0.0166 0.4306 0.4054
0.0222 0.3068 0.4574
0.056 0.5067 0.5065
0.0827 0.3354 0.532
0.0425 0.2515 0.5135
0.03 0.267 0.4054
0.0925 0.5133 0.4054
0.0274 0.5038 0.5034
0.0355 0.3858 0.4054
0.0298 0.2904 0.4054
0.0268 0.2931 0.4054
0.0873 0.4551 0.4054
0.0087 0.2736 0
0.0377 0.359 0.4054
0.024 0.3344 1
0.0264 0.506 0.4054
0.0047 0.4054 0.4054
0.0594 0.5098 0.5067
0.0281 0.3047 0
0.0152 0.3045 0.484
0.0671 0.2717 1
0.0704 0.2766 0.4054
0.0553 0.2994 0.4054
0.0706 0.5087 0.5083
0.0011 0.2757 0
0.0426 0.4127 0.4054
0.0134 0.4489 0.4429
0.0255 0.5102 0.4054
0.0039 0.2757 0.1948
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0.0419 0.4162 0.4974
0.0058 0.2684 0.417
0.0134 0.8895 1
0.0113 0.2528 0
0.0255 0.2866 0.5165
0.0586 0.2957 0
0.0245 0.3276 1
0.0375 0.3274 0.4054
0.0046 0.2757 0
0.0243 0.2662 0.433
0.0110351 0.405405 0.405405
0.0222 0.4459 1
0.068 0.5087 0.5083
0.034 0.2804 0.5314
0.0771 0.2909 0.4054
0.0296 0.4388 0.4054
0.0154 0.3011 0.4054
0.0446 0.6188 1
0.0441 0.4054 0.4054
0.0432 0.5089 0.5069
0.0059 0.4054 0.4054
0.0395 0.3694 0.4054
0.1083 0.4982 0.4054

Assayability

Assay information

  • ChEMBL
  • Inhibition of Plasmodium falciparum W2 cysteine protease
  • ChEMBL
  • Inhibition of Plasmodium falciparum 3D7 falcipain-1 by fluorescence spectrophotometry

Reagent availability

No reagent availability information for this target.

Bibliographic References

4 literature references were collected for this gene.

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Gene identifier PF3D7_1458000 (Plasmodium falciparum), cysteine proteinase falcipain 1
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