Detailed view for Smp_005790

Basic information

TDR Targets ID: 288309
Schistosoma mansoni, GTP-binding protein (q) alpha-11 subunit gna11
Source Database / ID:  GeneDB

pI: 5.0415 | Length (AA): 353 | MW (Da): 41578 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00503   G-protein alpha subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0001664   G-protein-coupled receptor binding  
GO:0031683   G-protein beta/gamma-subunit binding  
GO:0005525   GTP binding  
GO:0004871   signal transducer activity  
GO:0003924   GTPase activity  
GO:0019001   guanyl nucleotide binding  
GO:0007186   G-protein coupled receptor protein signaling pathway  
GO:0007165   signal transduction  
GO:0006471   protein amino acid ADP-ribosylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 348 3ah8 (A) 13 354 76.00 0 1 1.91947 -1.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130780)

Species Accession Gene Product
Brugia malayi Bm1_28970   G-protein alpha subunit
Caenorhabditis elegans CELE_M01D7.7   Protein EGL-30, isoform A
Drosophila melanogaster Dmel_CG17759   G protein alpha q subunit
Echinococcus granulosus EgrG_000305900   expressed protein
Echinococcus granulosus EgrG_000306000   expressed protein
Echinococcus multilocularis EmuJ_000306000   expressed protein
Echinococcus multilocularis EmuJ_000305900   expressed protein
Homo sapiens ENSG00000088256   guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Homo sapiens ENSG00000156052   guanine nucleotide binding protein (G protein), q polypeptide
Homo sapiens ENSG00000156049   guanine nucleotide binding protein (G protein), alpha 14
Loa Loa (eye worm) LOAG_11472   hypothetical protein
Mus musculus ENSMUSG00000024639   guanine nucleotide binding protein, alpha q polypeptide
Mus musculus ENSMUSG00000024697   guanine nucleotide binding protein, alpha 14
Mus musculus ENSMUSG00000034781   guanine nucleotide binding protein, alpha 11
Schistosoma japonicum Sjp_0002770   Guanine nucleotide-binding protein G(q) subunit alpha, putative
Schistosoma japonicum Sjp_0040830   ko:K04634 guanine nucleotide binding protein (G protein), alpha q polypeptide, putative
Schistosoma mansoni Smp_005790   GTP-binding protein (q) alpha-11 subunit gna11
Schistosoma mansoni Smp_132750   GTP-binding protein (q) alpha-11 subunit gna11
Schmidtea mediterranea mk4.000503.01   GTP-binding protein
Schmidtea mediterranea mk4.001188.07   EGL-30
Schmidtea mediterranea mk4.000153.21  
Schmidtea mediterranea mk4.000503.02   GTP-binding protein
Schmidtea mediterranea mk4.001188.06   Putative gtp-binding protein

Essentiality

Smp_005790 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_M01D7.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_M01D7.7 Caenorhabditis elegans larval arrest wormbase
CELE_M01D7.7 Caenorhabditis elegans larval lethal wormbase
CELE_M01D7.7 Caenorhabditis elegans slow growth wormbase
CELE_M01D7.7 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_005790 (Schistosoma mansoni), GTP-binding protein (q) alpha-11 subunit gna11
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