Detailed view for Smp_011230

Basic information

TDR Targets ID: 288518
Schistosoma mansoni, glycosylphosphatidylinositol:protein transamidase (C13 family)

Source Database / ID:  SchistoDB.net  GeneDB

pI: 4.8644 | Length (AA): 245 | MW (Da): 27913 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Pfam domains

PF01650   Peptidase C13 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016255   attachment of GPI anchor to protein  
GO:0003923   GPI-anchor transamidase activity  
GO:0042765   GPI-anchor transamidase complex  
GO:0008233   peptidase activity  
GO:0004197   cysteine-type endopeptidase activity  
GO:0006508   proteolysis  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 185 4noj (A) 71 254 32.00 0 1 1.0791 0.25
1 221 4d3z (A) 74 290 27.00 0 1 1.21814 -0.15
1 239 5zbi (A) 88 334 25.00 0 1 1.26641 -0.24
1 244 4d3z (A) 74 309 28.00 0 1 1.31482 -0.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128053)

Species Accession Gene Product
Arabidopsis thaliana AT1G08750   putative glycosylphosphatidylinositol-anchor transamidase
Babesia bovis BBOV_I000200   conserved hypothetical protein
Brugia malayi Bm1_16030   GPI-anchor transamidase
Candida albicans CaO19.10317   similar to S. cerevisiae GPI8 (YDR331W) subunit of GPI transamidase complex
Candida albicans CaO19.2799   similar to S. cerevisiae GPI8 (YDR331W) subunit of GPI transamidase complex
Caenorhabditis elegans CELE_T05E11.6   Protein HPO-4
Cryptosporidium hominis Chro.10032   GPI-anchor transamidase (U32517) -related
Cryptosporidium parvum cgd1_220   glycosylphosphatidylinositol transamidase, involved in GPI anchor biosynthesis
Dictyostelium discoideum DDB_G0285461   phosphatidylinositol glycan, class K
Drosophila melanogaster Dmel_CG4406   CG4406 gene product from transcript CG4406-RA
Echinococcus granulosus EgrG_000869600   GPI anchor transamidase
Entamoeba histolytica EHI_092280   GPI-anchor transamidase, putative
Echinococcus multilocularis EmuJ_000869600   GPI anchor transamidase
Giardia lamblia GL50803_15267   GPI-anchor transamidase, putative
Homo sapiens ENSG00000142892   phosphatidylinositol glycan anchor biosynthesis, class K
Leishmania braziliensis LbrM.18.0380   GPI-anchor transamidase subunit 8 (GPI8), putative
Leishmania donovani LdBPK_180360.1   GPI-anchor transamidase subunit 8 (GPI8), putative
Leishmania infantum LinJ.18.0360   GPI-anchor transamidase subunit 8 (GPI8), putative
Leishmania major LmjF.18.0360   GPI-anchor transamidase subunit 8 (GPI8), putative
Leishmania mexicana LmxM.18.0360   GPI-anchor transamidase subunit 8 (GPI8), putative,cysteine peptidase, Clan CD, family C13, putative
Loa Loa (eye worm) LOAG_06136   hypothetical protein
Mus musculus ENSMUSG00000039047   phosphatidylinositol glycan anchor biosynthesis, class K
Neospora caninum NCLIV_007520   hypothetical protein
Oryza sativa 4328747   Os02g0219400
Plasmodium berghei PBANKA_0919500   GPI-anchor transamidase, putative
Plasmodium falciparum PF3D7_1128700   GPI-anchor transamidase, putative
Plasmodium knowlesi PKNH_0926800   GPI-anchor transamidase, putative
Plasmodium vivax PVX_092055   GPI-anchor transamidase, putative
Plasmodium yoelii PY03470   GPI8p transamidase-related
Saccharomyces cerevisiae YDR331W   Gpi8p
Schistosoma japonicum Sjp_0124340   ko:K05290 phosphatidylinositol glycan, class K, putative
Schistosoma japonicum Sjp_0074300   Putative GPI-anchor transamidase precursor, putative
Schistosoma mansoni Smp_011230 this record   glycosylphosphatidylinositol:protein transamidase (C13 family)
Schmidtea mediterranea mk4.003944.01   Putative GPI-anchor transamidase
Trypanosoma brucei gambiense Tbg972.10.17040   GPI-anchor transamidase subunit 8 (GPI8),cysteine peptidase, Clan CD, family C13, putative
Trypanosoma brucei Tb927.10.13860   GPI-anchor transamidase subunit 8 (GPI8)
Trypanosoma congolense TcIL3000_10_11820   GPI-anchor transamidase subunit 8 (GPI8)
Trypanosoma cruzi TcCLB.511277.450   cysteine peptidase, Clan CD, family C13, putative
Toxoplasma gondii TGME49_252440   peptidase c13 family protein
Theileria parva TP03_0846   GPI-anchor transamidase, putative
Trichomonas vaginalis TVAG_277470   Clan CD, family C13, legumain-like cysteine peptidase
Trichomonas vaginalis TVAG_035520   Clan CD, family C13, legumain-like cysteine peptidase
Trichomonas vaginalis TVAG_060430   Clan CD, family C13, legumain-like cysteine peptidase

Essentiality

Smp_011230 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.13860 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.13860 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.13860 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.13860 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
YDR331W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0919500 Plasmodium berghei Essential plasmo
TGME49_252440 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania major GPI-anchor transamidase subunit 8 (GPI8), putative Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_011230 (Schistosoma mansoni), glycosylphosphatidylinositol:protein transamidase (C13 family)
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