pI: 9.2759 |
Length (AA): 2483 |
MW (Da): 279598 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2056 | 2423 | 4y83 (A) | 79 | 388 | 24.00 | 0 | 1 | -0.00139219 | 0.66 |
2091 | 2426 | 6fyl (A) | 145 | 482 | 68.00 | 0 | 1 | 1.03692 | -1.35 |
2096 | 2423 | 6ft8 (A) | 148 | 477 | 59.00 | 0 | 1 | 0.945698 | -1.37 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126990)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G32660 | protein kinase AME3 |
Arabidopsis thaliana | AT3G53570 | serine/threonine-protein kinase AFC1 |
Arabidopsis thaliana | AT4G24740 | LAMMER-type protein kinase AFC2 |
Babesia bovis | BBOV_IV001230 | protein serine/threonine kinase 1 |
Brugia malayi | Bm1_30560 | Protein kinase domain containing protein |
Candida albicans | CaO19.4979 | Serine/threonine protein kinase |
Candida albicans | CaO19.12446 | Serine/threonine protein kinase |
Caenorhabditis elegans | CELE_E02H4.3 | Protein TAG-172, isoform B |
Cryptosporidium hominis | Chro.50371 | serine/threonine kinase-1 |
Cryptosporidium parvum | cgd5_250 | serine/threonine kinase-1 |
Dictyostelium discoideum | DDB_G0281179 | CLK family protein kinase |
Drosophila melanogaster | Dmel_CG42320 | Darkener of apricot |
Echinococcus granulosus | EgrG_000340100 | hypothetical protein |
Echinococcus granulosus | EgrG_000482500 | dual specificity protein kinase clk2 |
Echinococcus multilocularis | EmuJ_000340100 | |
Echinococcus multilocularis | EmuJ_000482500 | dual specificity protein kinase clk2 |
Giardia lamblia | GL50803_92741 | Kinase, CMGC CLK |
Homo sapiens | ENSG00000013441 | CDC-like kinase 1 |
Homo sapiens | ENSG00000179335 | CDC-like kinase 3 |
Homo sapiens | ENSG00000113240 | CDC-like kinase 4 |
Homo sapiens | ENSG00000176444 | CDC-like kinase 2 |
Leishmania braziliensis | LbrM.09.0420 | protein kinase, putative |
Leishmania infantum | LinJ.09.0460 | protein kinase, putative |
Leishmania infantum | LinJ.09.0450 | protein kinase, putative |
Leishmania major | LmjF.09.0410 | protein kinase, putative |
Leishmania major | LmjF.09.0400 | protein kinase, putative |
Leishmania mexicana | LmxM.09.0400 | protein kinase, putative |
Leishmania mexicana | LmxM.09.0410 | |
Loa Loa (eye worm) | LOAG_05523 | hypothetical protein |
Loa Loa (eye worm) | LOAG_05522 | CMGC/CLK protein kinase |
Mus musculus | ENSMUSG00000032316 | CDC-like kinase 3 |
Mus musculus | ENSMUSG00000068917 | CDC-like kinase 2 |
Mus musculus | ENSMUSG00000020385 | CDC like kinase 4 |
Mus musculus | ENSMUSG00000026034 | CDC-like kinase 1 |
Neospora caninum | NCLIV_048210 | hypothetical protein |
Oryza sativa | 4326374 | Os01g0590900 |
Oryza sativa | 4327372 | Os01g0837900 |
Plasmodium berghei | PBANKA_1309200 | serine/threonine kinase-1, putative |
Plasmodium falciparum | PF3D7_1445400 | protein serine/threonine kinase-1 |
Plasmodium knowlesi | PKNH_1236900 | serine/threonine kinase-1, putative |
Plasmodium vivax | PVX_118220 | serine/threonine kinase-1, putative |
Plasmodium yoelii | PY06874 | protein serine/threonine kinase-1 |
Saccharomyces cerevisiae | YLL019C | Kns1p |
Schistosoma japonicum | Sjp_0013010 | expressed protein |
Schistosoma japonicum | Sjp_0080140 | Serine/threonine-protein kinase Doa, putative |
Schistosoma japonicum | Sjp_0019720 | ko:K08823 CDC-like kinase, putative |
Schistosoma mansoni | Smp_058620 | serine/threonine protein kinase |
Schistosoma mansoni | Smp_134560 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.020391.00 | Serine/threonine kinase |
Schmidtea mediterranea | mk4.044861.00 | Serine/threonine kinase |
Schmidtea mediterranea | mk4.002325.02 | Serine/threonine kinase |
Schmidtea mediterranea | mk4.002777.00 | |
Schmidtea mediterranea | mk4.015470.00 | Serine/threonine kinase |
Schmidtea mediterranea | mk4.025279.00 | Serine/threonine kinase |
Schmidtea mediterranea | mk4.000061.05 | Serine/threonine kinase |
Schmidtea mediterranea | mk4.003857.01 | Serine/threonine kinase |
Trypanosoma brucei gambiense | Tbg972.11.13870 | protein kinase, putative |
Trypanosoma brucei | Tb927.11.12410 | kinetoplastid kinetochore protein 10 |
Trypanosoma brucei | Tb927.11.12420 | kinetoplastid kinetochore protein 19 |
Trypanosoma congolense | TcIL3000.11.13030 | kinetoplastid kinetochore protein 10, putative |
Trypanosoma congolense | TcIL3000_0_20360 | kinetoplastid kinetochore protein, putative |
Trypanosoma congolense | TcIL3000_0_27770 | kinetoplastid kinetochore protein, putative |
Trypanosoma cruzi | TcCLB.511127.330 | kinetoplastid kinetochore protein 19, putative |
Trypanosoma cruzi | TcCLB.509027.60 | kinetoplastid kinetochore protein 10, putative |
Trypanosoma cruzi | TcCLB.511127.320 | kinetoplastid kinetochore protein 10, putative |
Trypanosoma cruzi | TcCLB.509027.70 | kinetoplastid kinetochore protein 19, putative |
Toxoplasma gondii | TGME49_224480 | cell-cycle-associated protein kinase CLK, putative |
Theileria parva | TP01_0149 | serine/threonine protein kinase, putative |
Trichomonas vaginalis | TVAG_246960 | CMGC family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.4250 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.4250 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.4250 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.4250 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb11.01.4230 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.4230 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.4230 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.4230 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1309200 | Plasmodium berghei | Essential | plasmo |
TGME49_224480 | Toxoplasma gondii | Essentiality uncertain | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | CDC-like kinase 3 | Compounds | References |
Homo sapiens | CDC-like kinase 4 | Compounds | References |
Mus musculus | CDC-like kinase 2 | Compounds | References |
Mus musculus | CDC like kinase 4 | Compounds | References |
Mus musculus | CDC-like kinase 1 | Compounds | References |
Homo sapiens | CDC-like kinase 3 | Compounds | References |
Homo sapiens | CDC-like kinase 2 | Compounds | References |
Homo sapiens | CDC-like kinase 1 | Compounds | References |