pI: 7.8968 |
Length (AA): 1024 |
MW (Da): 114930 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 9
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
56 | 952 | 2o9j (A) | 34 | 854 | 21.00 | 0 | 1 | 0.854177 | 1.13 |
371 | 448 | 3c0w (A) | 111 | 186 | 30.00 | 0.22 | 0.12 | 0.252672 | 0.79 |
414 | 665 | 1mo7 (A) | 383 | 593 | 19.00 | 0 | 0.78 | 0.0372938 | 0.98 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127596)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_IV003630 | phospholipid-translocating P-type ATPase, putative |
Brugia malayi | Bm1_27560 | potential phospholipid-transporting ATPase IIB, putative |
Candida albicans | CaO19.8405 | ATPase |
Candida albicans | CaO19.783 | ATPase |
Caenorhabditis elegans | CELE_F36H2.1 | Protein TAT-5, isoform C |
Caenorhabditis elegans | CELE_F02C9.3 | Protein TAT-6 |
Cryptosporidium hominis | Chro.20257 | ATPas, class II, type 9B; ATPase, class 2, member b; ATPase 9B, p type; ATPase 9B, class II |
Cryptosporidium parvum | cgd2_2400 | ATPase, class II, type 9B, putative |
Dictyostelium discoideum | DDB_G0270870 | ATPase, class II, type 9B |
Drosophila melanogaster | Dmel_CG31729 | CG31729 gene product from transcript CG31729-RB |
Echinococcus granulosus | EgrG_000172600 | phospholipid transporting ATPase IIB |
Entamoeba histolytica | EHI_197300 | phospholipid-transporting ATPase Neo1, putative |
Entamoeba histolytica | EHI_049640 | phospholipid-transporting P-type ATPase, putative |
Entamoeba histolytica | EHI_168260 | phospholipid-transporting P-type ATPase, putative |
Echinococcus multilocularis | EmuJ_000172600 | phospholipid transporting ATPase IIB |
Giardia lamblia | GL50803_16958 | Phospholipid-transporting ATPase IA, putative |
Giardia lamblia | GL50803_137725 | Phospholipid-transporting ATPase IIB, putative |
Giardia lamblia | GL50803_101810 | Phospholipid-transporting ATPase IIB, putative |
Giardia lamblia | GL50803_88438 | ATPase |
Giardia lamblia | GL50803_38104 | Phospholipid-transporting ATPase IIB, putative |
Homo sapiens | ENSG00000166377 | ATPase, class II, type 9B |
Homo sapiens | ENSG00000054793 | ATPase, class II, type 9A |
Leishmania donovani | LdBPK_343000.1 | aminophospholipid translocase, putative |
Leishmania infantum | LinJ.34.3000 | aminophospholipid translocase, putative |
Leishmania major | LmjF.34.3220 | aminophospholipid translocase, putative |
Leishmania mexicana | LmxM.33.3220 | aminophospholipid translocase, putative |
Loa Loa (eye worm) | LOAG_13053 | transbilayer Amphipath transporters family member |
Loa Loa (eye worm) | LOAG_02497 | transbilayer Amphipath transporters family member |
Mus musculus | ENSMUSG00000024566 | ATPase, class II, type 9B |
Mus musculus | ENSMUSG00000027546 | ATPase, class II, type 9A |
Neospora caninum | NCLIV_048370 | phospholipid-transporting ATPase, P-type, putative |
Plasmodium berghei | PBANKA_1438300 | phospholipid-transporting ATPase, putative |
Plasmodium falciparum | PF3D7_1223400 | phospholipid-transporting ATPase, putative |
Plasmodium knowlesi | PKNH_1442600 | phospholipid-transporting ATPase, putative |
Plasmodium vivax | PVX_123800 | phospholipid-transporting ATPase, putative |
Plasmodium yoelii | PY06483 | similar to ATPase, class II, type 9A |
Saccharomyces cerevisiae | YIL048W | putative aminophospholipid-translocating P4-type ATPase NEO1 |
Schistosoma japonicum | Sjp_0130010 | Probable phospholipid-transporting ATPase IIB, putative |
Schistosoma japonicum | Sjp_0052350 | ko:K01530 phospholipid-translocating ATPase [EC3.6.3.1], putative |
Schistosoma japonicum | Sjp_0052370 | ko:K01530 phospholipid-translocating ATPase [EC3.6.3.1], putative |
Schistosoma mansoni | Smp_091650 | cation-transporting ATPase |
Schmidtea mediterranea | mk4.001013.07 | Putative cation-transporting ATPase |
Schmidtea mediterranea | mk4.001013.09 | Putative cation-transporting ATPase |
Schmidtea mediterranea | mk4.001013.08 | |
Schmidtea mediterranea | mk4.001013.06 | Putative cation-transporting ATPase |
Trypanosoma brucei gambiense | Tbg972.4.1360 | phospholipid-translocating ATPase, putative |
Trypanosoma brucei | Tb927.4.1510 | phospholipid-translocating ATPase, putative |
Trypanosoma cruzi | TcCLB.511003.10 | phospholipid-translocating ATPase, putative |
Trypanosoma cruzi | TcCLB.504057.11 | phospholipid-translocating ATPase, putative |
Toxoplasma gondii | TGME49_224190 | cation-transporting atpase family protein |
Theileria parva | TP02_0772 | phospholipid-transporting ATPase, putative |
Trichomonas vaginalis | TVAG_119100 | cation-transporting ATPase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.1510 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.1510 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.1510 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.4.1510 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F36H2.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F36H2.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F36H2.1 | Caenorhabditis elegans | sterile | wormbase |
YIL048W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1438300 | Plasmodium berghei | Slow | plasmo |
TGME49_224190 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 994 aa | 22.1% | 850 aa | Compounds | References |
Oryctolagus cuniculus | Sarcoplasmic/endoplasmic reticulum calcium ATP-ase | 1001 aa | 22.2% | 847 aa | Compounds | References |