Detailed view for Smp_188980

Basic information

TDR Targets ID: 289121
Schistosoma mansoni, tubulin subunit alpha
Source Database / ID:  GeneDB

pI: 5.5529 | Length (AA): 169 | MW (Da): 18575 | Paralog Number: 2305

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00091   Tubulin/FtsZ family, GTPase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0043234   protein complex  
GO:0005874   microtubule  
GO:0005525   GTP binding  
GO:0005200   structural constituent of cytoskeleton  
GO:0005198   structural molecule activity  
GO:0003924   GTPase activity  
GO:0051258   protein polymerization  
GO:0007018   microtubule-based movement  
GO:0007017   microtubule-based process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 169 4i4t (A) 1 169 98.00 0 1 2.2675 -1.96

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Leishmania donovani Beta tubulin 43 aa 42.9% 42 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0563 0.2544 0.2544
0.0546 0.2545 0.2542
0.0085 0.3918 0.3496
0.0843 0.2537 0.2531
0.0043 0.4107 0.4063
0.0402 0.2538 0.2538
0.0401 0.2516 0.2516
0.0409 0.2544 0.2542
0.0069 0.3392 0.3392
0.0045 0.2537 0
0.0546 0.2544 0.2544
0.004 0.2973 0.2973
0.0054 0.2833 0.0845
0.0402 0.2538 0.2538
0.0302 0.2563 0.2538
0.0034 0.3051 0.3051
0.0848 0.2545 0.2538
0.0126 0.2524 0.2524
0.0046 0.2632 0.0226
0.0403 0.2536 0.2532
0.0102 0.3953 0.3953
0.0057 0.393 0.393
0.0538 0.2536 0.2536
0.0849 0.2532 0.2532
0.0051 0.3883 0.3883
0.0222 0.2501 0.2496
0.0068 0.2651 0.2651
0.0535 0.2519 0.2519
0.0072 0.4058 0.4058
0.0723 0.2529 0.2529
0.0551 0.2529 0.2529
0.0066 0.35 0
0.056 0.2514 0.2514
0.0101 0.3552 0.3552
0.0546 0.2545 0.2542
0.0402 0.2538 0.2538
0.0074 0.4006 0.385
0.0047 0.2592 0.0097
0.0083 0.2616 0.2616
0.0729 0.2541 0.2541
0.0026 0.2908 0.2908
0.0067 0.252 0
0.0265 0.2509 0.2509
0.0525 0.2545 0.2545
0.0719 0.2541 0.2541
0.0546 0.2544 0.2544
0.0561 0.2529 0.2529
0.0045 0.2572 0.003
0.0069 0.3392 0.3392
0.0525 0.2545 0.2545
0.0402 0.2538 0.2538
0.0841 0.2551 0.2551
0.0284 0.2518 0.2518
0.0428 0.2516 0.2516
0.04 0.2514 0.2514
0.0054 0.2826 0.0822
0.0546 0.2545 0.2542
0.0407 0.2502 0.2432
0.0092 0.4079 0.4079
0.0406 0.2514 0.2514
0.0045 0.3536 0.3536
0.0046 0.3108 0.3108
0.085 0.2537 0.253
0.0684 0.253 0.253

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_188980 (Schistosoma mansoni), tubulin subunit alpha
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