Detailed view for Smp_159890

Basic information

TDR Targets ID: 289361
Schistosoma mansoni, metallocarboxypeptidase D peptidase unit 2 (M14 family)
Source Database / ID:  GeneDB

pI: 6.9138 | Length (AA): 1693 | MW (Da): 191565 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00246   Zinc carboxypeptidase

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0004181   metallocarboxypeptidase activity  
GO:0004180   carboxypeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
54 433 1h8l (A) 8 380 49.00 0 1 0.876054 -1.04
57 350 2c1c (A) 10 309 17.00 0 1 0.295456 -0.8
58 457 1uwy (A) 4 403 40.00 0 1 0.692067 -0.68
144 345 1cpb (B) 93 304 19.00 0 0.12 -0.130885 1.74
349 435 5aq0 (A) 384 461 33.00 0 0.61 0.239188 0.15
427 1366 1z3h (A) 9 956 12.00 0 1 0.541027 0.46
1424 1505 5aq0 (A) 382 461 23.00 0.00016 0.63 0.304835 -0.68

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130608)

Species Accession Gene Product
Arabidopsis thaliana AT1G71696   putative Zn2+ carboxypeptidase
Caenorhabditis elegans CELE_T27A8.1   Protein CPD-2
Dictyostelium discoideum DDB_G0288963   peptidase M14 family protein
Drosophila melanogaster Dmel_CG4122   silver
Homo sapiens ENSG00000108582   carboxypeptidase D
Mus musculus ENSMUSG00000020841   carboxypeptidase D
Oryza sativa 4340100   Os06g0144600
Schistosoma japonicum Sjp_0013530   ko:K07752 carboxypeptidase D [EC3.4.17.22], putative
Schistosoma mansoni Smp_159890   metallocarboxypeptidase D peptidase unit 2 (M14 family)
Schmidtea mediterranea mk4.001424.07   Carboxypeptidase D
Schmidtea mediterranea mk4.001424.06   Carboxypeptidase D
Schmidtea mediterranea mk4.001424.03  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_159890 (Schistosoma mansoni), metallocarboxypeptidase D peptidase unit 2 (M14 family)
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