Detailed view for Smp_096020.1

Basic information

TDR Targets ID: 289587
Schistosoma mansoni, adenosylhomocysteinase
Source Database / ID:  GeneDB

pI: 7.2747 | Length (AA): 492 | MW (Da): 54293 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00670   S-adenosyl-L-homocysteine hydrolase, NAD binding domain
PF05221   S-adenosyl-L-homocysteine hydrolase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004013   adenosylhomocysteinase activity  
GO:0003824   catalytic activity  
GO:0005488   binding  
GO:0008152   metabolic process  
GO:0006730   one-carbon compound metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
94 489 3gvp (A) 179 574 72.00 0 1 1.73918 -1.21

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130931)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG8956   Adenosylhomocysteinase 89E
Drosophila melanogaster Dmel_CG9977   CG9977 gene product from transcript CG9977-RA
Homo sapiens ENSG00000168710   adenosylhomocysteinase-like 1
Homo sapiens ENSG00000158467   adenosylhomocysteinase-like 2
Mus musculus ENSMUSG00000029772   S-adenosylhomocysteine hydrolase-like 2
Mus musculus ENSMUSG00000027893   S-adenosylhomocysteine hydrolase-like 1
Schistosoma japonicum Sjp_0043030   IPR000043,S-adenosyl-L-homocysteine hydrolase,domain-containing
Schistosoma japonicum Sjp_0083290   Putative adenosylhomocysteinase 3, putative
Schistosoma japonicum Sjp_0207650   ko:K01251 adenosylhomocysteinase [EC3.3.1.1], putative
Schistosoma mansoni Smp_096020.3   adenosylhomocysteinase
Schistosoma mansoni Smp_096020.1   adenosylhomocysteinase
Schistosoma mansoni Smp_096020.2   adenosylhomocysteinase
Schmidtea mediterranea mk4.013301.00   Adenosylhomocysteinase
Schmidtea mediterranea mk4.001016.06  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens adenosylhomocysteinase-like 1 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Adenosylhomocysteinase 432 aa 50.9% 385 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0097 0.4444 0
0.0398 0.263 0.3477
0.0252 0.4842 0.1264
0.0082 0.4009 0.4425
0.0232 0.2675 0.2651
0.0255 0.3119 0.3672
0.1051 0.4873 0.6157
0.0097 0.4775 0.4775
0.0732 0.2771 0.2771
0.0623 0.6048 0.5999
0.0509 0.6123 0.6123
0.0841 0.5635 0.5635
0.1136 0.6161 0.6161
0.0592 0.5073 0.5073
0.0237 0.4444 0
0.0553 0.6077 0.6027
0.0097 0.4444 0
0.0195 1 1
0.0744 0.5556 0.6157
0.0796 0.5636 0.6177
0.0561 0.6139 0.6139
0.0552 0.5138 0.6111
0.04 0.5807 0.5593
0.0567 0.3425 0.6154
0.0471 0.308 0.308
0.0984 0.5601 0.6154
0.0428 0.2898 0.3841
0.057689 0.556329 0.556329
0.0977 0.6126 0.6099
0.1234 0.6109 0.6109
0.1033 0.5169 0.6162
0.6047 0.3206 0.6174
0.0156 0.3362 0.4836
0.0479 0.5954 0.5939
0.0314 0.3719 0.6129
0.0155 0.4444 0.396
0.0481 0.6045 0.6045
0.1334 0.6158 0.6158
0.1038 0.2826 0.2825
0.0822 0.3847 0.3847
0.1107 0.6158 0.6158
0.0482 0.5719 0.5719
0.0817 0.2742 0.2741
0.1013 0.6118 0.6118
0.0182 0.5712 0.5712
0.0632 0.6136 0.6134
0.0984 0.5058 0.5027
0.033 0.3946 0.4649
0.0554 0.3664 0.6171
0.0637 0.6135 0.6128
0.0163 0.4444 0
0.0738 0.5468 0.6145
0.0182 0.6102 0.6093
0.0319 0.6072 0.6072
0.075 0.3482 0.3482
0.0182 0.4444 0
0.0083 0.4444 0
0.0817 0.2742 0.2741
0.1223 0.613 0.6107
0.1769 0.2993 0.6167
0.0934 0.5952 0.5952
0.1027 0.5133 0.6162
0.0414 0.5077 0.5982
0.0819 0.6127 0.6101
0.1192 0.6122 0.612
0.0741067 0.441973 0
0.0324 0.3615 0.6078
0.0156 0.4444 0.4016
0.0652 0.4821 0.6143
0.0505 0.6098 0.6028
0.0338 0.3799 0.6124
0.0505 0.6098 0.6028
0.0193 0.5968 0.5968
0.0237 0.4444 0
0.0591 0.5753 0.5753
0.0319 0.3597 0.6077
0.0733 0.5503 0.6143
0.0253 0.2996 0.6075
0.0326 0.3668 0.6136
0.024 0.5871 0.5871
0.0486 0.5866 0.6136
0.0398 0.3634 0.3634
0.0921 0.6172 0.6172
0.0603 0.988 0.9728
0.0632 0.6136 0.6134
0.0893 0.6136 0.6117
0.0654 0.4871 0.6144
0.033 0.547 0.547
0.0817 0.6143 0.6143
0.0893 0.5555 0.6154
0.1334 0.6158 0.6158
0.0713 0.3697 0.6152
0.065 0.6061 0.6061
0.0583 0.5737 0.5737
0.047 0.6029 0.5957
0.0326 0.6073 0.6073
0.0737 0.4462 0.6162
0.0505 0.6098 0.6028
0.0974 0.5006 0.6162
0.1038 0.2826 0.2825
0.0084 0.298 0.4363
0.0358 0.3619 0.6075
0.0497 0.353 0.6103
0.1899 0.5232 0.6181
0.05 0.6073 0.6071
0.0401 0.4444 0
0.0511 0.2673 0.3998
0.0489 0.5737 0.5737
0.0829 0.6109 0.6074
0.0435 0.4113 0.5863
0.0239 0.4444 0.4131
0.0087 0.2748 0.2748
0.0601 0.615 0.6149
0.0909 0.614 0.614
0.0955 0.3857 0.6138
0.1291 0.3876 0.6161
0.0241 0.253 0.335
0.0865 0.5047 0.6158
0.1136 0.6161 0.6161
0.1431 0.6159 0.6124
0.0477 0.2553 0.4484
0.0411 0.2925 0.3869
0.0732 0.2771 0.2771
0.0328 0.38 0.6124
0.0174 0.6071 0.6071
0.0554 0.6185 0.6185
0.1189 0.6156 0.6149
0.0741 0.5452 0.6148
0.0817 0.2742 0.2741
0.0437 0.2788 0.5976
0.0324 0.3615 0.6078
0.0947 0.6149 0.6149
0.0249 0.5726 0.5726
0.0893 0.5555 0.6154
0.0253 0.2996 0.6075
0.0374 0.4696 0.61
0.0243 0.2815 0
0.0493 0.6142 0.6141
0.0739 0.5595 0.6151
0.0817 0.2742 0.2741
0.0808 0.5609 0.6152
0.084 0.3051 0.6144
0.0453 0.4394 0.4531
0.121 0.6166 0.6166
0.0632 0.6136 0.6134
0.0569 0.4275 0.6135
0.0353 0.4038 0.6116
0.0651 0.3182 0.462
0.0632 0.6136 0.6134
0.0351 0.4184 0.513
0.1365 0.27 0.6158
0.0497 0.353 0.6103
0.075 0.3482 0.3482
0.1428 0.6554 0.6554
0.0647 0.4071 0.6155
0.0167 0.4444 0
0.0817 0.2742 0.2741
0.0578 0.6106 0.6106
0.0489 0.6046 0.6046
0.0414 0.2926 0.387
0.0086 0.4443 0.4443
0.0174 0.3233 0
0.0576 0.608 0.608
0.1222 0.6359 0.6359
0.0315 0.3095 0.3095
0.0317 0.3842 0.4518
0.1126 0.6154 0.6154
0.1107 0.6158 0.6158
0.1373 0.4444 0
0.0472 0.6105 0.5998
0.057 0.6122 0.6119
0.0753 0.6024 0.6024
0.1189 0.6156 0.6149
0.0157 0.5169 0.5069
0.0788 0.614 0.6117
0.0081 0.4444 0
0.6047 0.3206 0.6174
0.0651 0.3182 0.462
0.0992 0.6095 0.6095
0.0505 0.2677 0.4705
0.0345 0.3799 0.6124
0.0097 0.4444 0
0.0549 0.6124 0.6124
0.016 0.3009 0.3989
0.0651 0.3182 0.462
0.0733 0.5503 0.6143
0.065 0.5717 0.5455
0.0272 0.2686 0.361
0.0926 0.6164 0.6164
0.0696 0.604 0.604
0.1148 0.6169 0.6169
0.0082 0.4444 0
0.0359 0.5763 0.5169
0.0817 0.2742 0.2741
0.0193 0.5968 0.5968
0.0312 0.5358 0.5358
0.0754 0.6103 0.6103
0.0732 0.2771 0.2771
0.0377 0.3365 0.3365
0.0251 0.4444 0
0.0697 0.4444 0
0.0832 0.5915 0.5915
0.0559 0.4706 0.4706
0.0317 0.3842 0.4518
0.0331 0.3938 0.6105
0.0743 0.555 0.555
0.0332 0.3322 1
0.1059 0.6161 0.6161
0.048 0.6063 0.6007
0.6047 0.3206 0.6174
0.0421 0.8323 0.8323
0.1802 0.4965 0.618
0.0725 0.6064 0.6007
0.0652 0.5314 0.5303
0.0521 0.2957 0.4551
0.075 0.3482 0.3482
0.0414 0.5077 0.5982
0.1365 0.27 0.6158
0.0832 0.5915 0.5915
0.6698 0.3141 0.6179
0.0569 0.4444 0
0.0079 0.4444 0
0.1794 0.2702 0.6174
0.0097 0.3642 0.5222
0.057 0.6122 0.6119
0.6047 0.3206 0.6174
0.0097 0.3642 0.5222
0.0174 0.3233 0
0.1046 0.6167 0.6167
0.0155 0.2946 0.5562
0.0078 0.4444 0
0.0734 0.5703 0.6152
0.0473 0.5705 0.5705
0.0332 0.3322 1
0.0906 0.5566 0.6154
0.0195 1 1
0.0253 0.2996 0.6075
0.0356 0.3618 0.6074
0.0316 0.3778 0.444
0.0807 0.593 0.593
0.1363 0.6115 0.6115
0.0719 0.5964 0.5964
0.0414 0.2935 0.377
0.1046 0.6167 0.6167
0.0945 0.4444 0
0.1333 0.6173 0.6168
0.057 0.3168 0.6144
0.0732 0.6028 0.6028
0.1365 0.27 0.6158
0.0314 0.5921 0.5921
0.0578 0.6106 0.6106
0.0086 0.4443 0.4443
0.0817 0.2742 0.2741
0.0374 0.4696 0.61
0.0588 0.5869 0.5869
0.0428 0.29 0.3843
0.0251 0.511 0.5923
0.0314 0.3781 0.4443
0.0481 0.6045 0.6045
0.075 0.3482 0.3482
0.1295 0.6156 0.6156
0.0678 0.6046 0.6046
0.0182 0.5712 0.5712
0.1133 0.5221 0.6159
0.0898 0.5459 0.6163
0.0804 0.4875 0.6165
0.041 0.5572 0.5572
0.0605 0.615 0.6149
0.0081 0.4069 0.4069
0.1189 0.6156 0.6149
0.0317 0.3842 0.4518
0.1047 0.6147 0.6095
0.0727 0.4026 0.6148
0.0242 0.3107 0
0.00702812 0.362512 0.499101
0.0565 0.4246 0.6135
0.0155 0.4444 0
0.1871 0.6161 0.6149
0.0921 0.6172 0.6172
0.0163 0.5708 0.5708
0.0637 0.6135 0.6128
0.049 0.3512 0.3512
0.1135 0.586 0.6157
0.0082 0.4009 0.4425
0.0863 0.6121 0.6109
0.0883 0.3348 0.5955
0.1027 0.5077 0.6162
0.0097 0.4444 0
0.0822 0.3847 0.3847
0.1289 0.5911 0.6163
0.0931 0.6117 0.6117
0.0193 0.5968 0.5968
0.089 0.6102 0.6099
0.097 0.6111 0.6108
0.0511 0.2673 0.4021
0.0377 0.3365 0.3365
0.115 0.6169 0.6169
0.0505 0.6098 0.6028
0.0268 0.5773 0.5773
0.0509 0.2677 0.4706
0.6374 0.3189 0.618
0.075 0.3482 0.3482
0.0349 0.365 0.6122
0.0084 0.2557 0.2123
0.1189 0.6156 0.6149
0.0921 0.6102 0.6102
0.1059 0.6161 0.6161
0.0394 0.5574 0.5566
0.034 0.3799 0.6124
0.0652 0.3617 0.615
0.0581 0.4444 0
0.0645 0.5821 0.5821
0.0588 0.5869 0.5869
0.0505 0.6098 0.6028
0.0077 0.4444 0
0.0957 0.4758 0.616
0.0243 0.3216 0
0.084 0.6017 0.5928
0.0079 0.4444 0
0.0195 1 1
0.0822 0.3847 0.3847
0.0632 0.6136 0.6134
0.0738 0.5468 0.6145
0.0097 0.4444 0
0.0595 0.3079 0.4672
0.0728 0.3999 0.6155
0.075 0.3482 0.3482
0.0349 0.3773 0.6117
0.0332 0.3322 1
0.0244 0.5877 0.5877
0.0683 0.9009 0.9009
0.057 0.3168 0.6144
0.0652 0.5314 0.5303
0.1789 0.6157 0.6147
0.1389 0.4444 0
0.1291 0.3876 0.6161
0.0488 0.3679 0.6123
0.0906 0.5539 0.6167
0.0338 0.3908 0.5853
0.05 0.6073 0.6071
0.035 0.3785 0.6073
0.0255 0.4509 0.5895
0.0716 0.6087 0.6087
0.0632 0.6136 0.6134
0.0817 0.2742 0.2741
0.024 0.5871 0.5871
0.0411 0.4444 0
0.0331 0.364 0.6127
0.0155 0.4444 0
0.0183 0.3594 0.592
0.0351 0.3258 0.6076
0.0641 0.3782 0.6138
0.1095 0.5752 0
0.0679 0.3815 0.5314
0.0502 0.6142 0.6136
0.0737 0.4462 0.6162
0.00702812 0.362512 0.499101
0.043 0.6103 0.6103
0.0906 0.5566 0.6154
0.1428 0.6554 0.6554
0.0822 0.612 0.6113
0.0235 0.4444 0
0.0672 0.5779 0.5779
0.0239 0.2652 0.472
0.042 0.2918 0.386
0.0359 0.361 0.6086
0.0578 0.6106 0.6106
0.0087 0.276 0.276
0.1046 0.6167 0.6167
0.05 0.6073 0.6071
0.1579 0.6151 0.6116
0.04 0.5807 0.5593
0.0655 0.3964 0.6159
0.0253 0.3428 0.6053
0.1212 0.6152 0.6107
0.0549 0.6124 0.6124
0.0081 0.5114 0.5114
0.0817 0.2742 0.2741
0.1095 0.5752 0
0.1428 0.6554 0.6554
0.0097 0.4444 0
0.0744 0.5556 0.6157
0.1053 0.6163 0.6163
0.0651 0.3182 0.462
0.1428 0.6554 0.6554
0.0722 0.4337 0.6162
0.0487 0.3528 0.6184
0.0193 0.5477 0
0.0696 0.604 0.604
0.0962 0.444 0.6154
0.0088 0.4444 0.0589
0.0817 0.2742 0.2741
0.057 0.6122 0.6119
0.1072 0.613 0.6129
0.0488708 0.341047 0.590593
0.0331 0.4444 0
0.0696 0.604 0.604
0.0801 0.6103 0.6092
0.0236 0.5375 0.5375
0.1005 0.6029 0.6029
0.0175 0.6016 0.6016
0.0157 0.3353 0.3353
0.0578 0.6106 0.6106
0.0244 0.5877 0.5877
0.0508 0.2673 0.4005
0.1365 0.27 0.6158
0.0817 0.2742 0.2741
0.0078 0.4444 0
0.043 0.6103 0.6103
0.1044 0.5497 0.6162
0.0097 0.4775 0.4775
0.0318 0.604 0.6003
0.035 0.3785 0.6073
0.0905 0.6136 0.6125
0.0253 0.3428 0.6053
0.0269 0.4444 0
0.0907 0.6018 0.6018
0.0739 0.5595 0.6151
0.0326 0.954 0.8518
0.0084 0.298 0.4363
0.0366 0.6057 0.5886
0.0079 0.4444 0
0.0953 0.521 0.6162
0.0195 0.4222 0.4218
0.0496 1 1
0.0347 0.3798 0.6124
0.1036 0.4018 0.6155
0.0155 0.4444 0.396
0.0672 0.5779 0.5779
0.0097 0.4872 0.3405
0.1107 0.6158 0.6158
0.0406 0.2907 0.3857
0.0081 0.4444 0
0.0555 0.5618 0.5618
0.0345 0.3798 0.6124
0.0487 0.6184 0.6184
0.0808 0.5867 0.5867
0.1209 0.285 0.6162
0.0377 0.3365 0.3365
0.0909 0.614 0.614
0.0453 0.4394 0.4531
0.0338 0.3908 0.5853
0.0399 0.5853 0.5853
0.0732 0.5406 0.6141
0.0691 0.5847 0.5847
0.0724 0.6134 0.6067
0.0157 0.4444 0.3479
0.0351 0.4029 0.6108
0.6047 0.3206 0.6174
0.0738 0.6132 0.6062
0.1365 0.6016 0.6016
0.0156 0.3188 0.3682
0.1866 0.616 0.6148
0.0632 0.6136 0.6134
0.008 0.5383 0.5161
0.6374 0.3189 0.618
0.1186 0.3573 0.6159
0.0195 1 1
0.0668 0.7636 0.7636
0.084 0.3051 0.6144
0.0545 0.6148 0.613
0.0732 0.2771 0.2771
0.0909 0.614 0.614
0.0716 0.5997 0.5997

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_096020.1 (Schistosoma mansoni), adenosylhomocysteinase
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