Detailed view for Smp_172410

Basic information

TDR Targets ID: 289723
Schistosoma mansoni, serine/threonine protein kinase
Source Database / ID:  GeneDB

pI: 9.9558 | Length (AA): 1167 | MW (Da): 132604 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF03607   Doublecortin

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0007242   intracellular signaling cascade  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
122 202 5ip4 (D) 258 334 30.00 0 1 0.550609 -1.48
734 1167 1ym7 (A) 33 457 20.00 0 1 0.323994 0.59
901 1162 5jzj (A) 383 648 55.00 0 1 0.907207 -0.93
903 1165 2vz6 (A) 0 275 38.00 0 1 0.739564 -0.91
904 1162 1phk (A) 15 288 40.00 0 1 0.741137 -1.06
908 1051 4nt4 (A) 43 195 32.00 0.055 0.82 0.302093 0.63
909 1051 2cmw (A) 45 191 31.00 0.00015 0.95 0.380236 0.47

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_136044)

Species Accession Gene Product
Homo sapiens ENSG00000163673   doublecortin-like kinase 3
Mus musculus ENSMUSG00000032500   doublecortin-like kinase 3
Schistosoma japonicum Sjp_0063500   ko:K08805 doublecortin and CaM kinase-like 1, putative
Schistosoma japonicum Sjp_0063490   IPR003533,Doublecortin,domain-containing
Schistosoma mansoni Smp_172410   serine/threonine protein kinase
Schmidtea mediterranea mk4.000915.06   Serine/threonine-protein kinase DCLK3
Schmidtea mediterranea mk4.002011.01   Calcium/calmodulin-dependent protein kinase I
Schmidtea mediterranea mk4.009801.01   Serine/threonine-protein kinase DCLK3
Schmidtea mediterranea mk4.009801.02  
Schmidtea mediterranea mk4.012003.01   Serine/threonine-protein kinase DCLK3

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens doublecortin-like kinase 3 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 39.5% 157 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 24.5% 294 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 28.1% 285 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 28.4% 285 aa Compounds References
Zea mays Casein kinase II alpha 332 aa 25.8% 291 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 27.2% 290 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 27.0% 300 aa Compounds References
Patiria pectinifera Cdc2 300 aa 27.8% 281 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 29.2% 284 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 30.2% 278 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0004 0.5 0.5
0.0342803 0.270833 0.340755
0.0007 0.5 0.5
0.0360473 0.252628 0.318489
0.0032 0.5 0.5
0.0018 0.5 0.5
0.0375086 0.252628 0.318489
0.0026 0.5 0.5
0.0027 1 1
0.0012 0.5 0.5
0.0091 1 1
0.0061 0.6883 0.6656
0.0042 0.5 0.5
0.0347591 0.255305 0.322906
0.0093 0.8828 0
0.0007 0.5 0.5
0.0059 1 1
0.0039 0.5 0.5
0.0069 0.3067 0.3067
0.0022 0.5 0.5
0.0039 0.9485 1
0.0037 1 0.5
0.0007 0.5 0.5
0.0039 0.5 0.5
0.0056 1 1
0.0016 0.5 0.5
0.0067 0.5 0.5
0.0344144 0.252403 0.323972
0.0066 0.3101 0.9479
0.0088 0.4477 0.6337
0.0059 1 1
0.0011 1 1
0.0023 0.5 0.5
0.0213911 0.259898 0.332585
0.0063 1 1
0.0012 0.5 0.5
0.0081 0.5 0.5
0.0063 0.7244 0
0.0062 0.6935 0.7231
0.0354115 0.252628 0.318176
0.0012 0.5 0.5
0.0064 0.3377 0.9531
0.0059 1 1
0.0036 0.5 0.5
0.0081 1 1
0.0092 1 1
0.0008 0.5 0.5
0.0404131 0.264673 0.3309
0.0003 0.5 0.5
0.0033 1 1
0.0029 0.5 0.5
0.0098 0.3242 0.2614
0.0385505 0.252628 0.318489
0.0033 0.5 0.5
0.0016 0.5 0.5
0.0032 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_172410 (Schistosoma mansoni), serine/threonine protein kinase
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