Detailed view for Smp_110860

Basic information

TDR Targets ID: 289808
Schistosoma mansoni, Replicative DNA helicase
Source Database / ID:  GeneDB

pI: 7.3837 | Length (AA): 483 | MW (Da): 54775 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00772   DnaB-like helicase N terminal domain
PF03796   DnaB-like helicase C terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0003678   DNA helicase activity  
GO:0003677   DNA binding  
GO:0006260   DNA replication  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
18 480 4esv (B) 8 444 35.00 0 1 1.26559 0.27
20 129 1jwe (A) 26 135 30.00 0 1 0.737043 -1.29
21 481 4esv (B) 11 445 38.00 0 1 1.32175 0.08
21 162 2r5u (A) 25 166 20.00 0 0.83 0.645296 -0.88
156 221 3ifq (A) 247 308 45.00 0.21 0.53 0.528246 0.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131890)

Species Accession Gene Product
Chlamydia trachomatis CT_497   replicative DNA helicase
Escherichia coli b4052   replicative DNA helicase
Mycobacterium leprae ML2680c   PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase
Mycobacterium tuberculosis Rv0058   Probable replicative DNA helicase DnaB
Mycobacterium ulcerans MUL_0075   replicative DNA helicase DnaB
Schistosoma mansoni Smp_110860   Replicative DNA helicase
Schmidtea mediterranea mk4.039420.00  
Treponema pallidum TP0058   replicative DNA helicase (dnaB)
Wolbachia endosymbiont of Brugia malayi Wbm0299   replicative DNA helicase

Essentiality

Smp_110860 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu58 Mycobacterium tuberculosis essential nmpdr
b4052 Escherichia coli essential goodall
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Staphylococcus aureus DnaC helicase Compounds References
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB Compounds References
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) Replicative DNA helicase Compounds References
Bacillus anthracis Replicative DNA helicase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0778 1 1
0.2066 0.2699 0.2699
0.0632 0.8805 0.5
0.2066 0.2699 0.2699
0.0652 0.435 0.4347
0.0631 0.4439 0.9673
0.0778 0.3074 1
0.724 1 1
0.2066 0.2699 0.2699
0.866 1 1
0.2066 0.2699 0.2699
0.9461 1 1
0.3217 1 1
0.2066 0.2699 0.2699
0.2066 0.2699 0.2699
0.0652 0.3581 0.8022
0.2066 0.2699 0.2699
0.0627 0.3989 0.7042
0.7294 1 1
0.0635 0.3805 1
0.5601 1 1
0.0634 0.3005 0.9486
0.6544 1 1
0.0466 0.2974 0.3565
0.2066 0.2699 0.2699
0.0639 0.2511 0.8886
0.3217 1 1
0.6248 0.5722 1
0.6248 0.5722 1
0.3856 1 1
0.0718 0.3848 1
0.065 0.5046 1
1.0701 1 1
0.0639 0.2548 0.8906
0.0752 1 1
0.127 0.3805 1
0.2066 0.2699 0.2699
0.2066 0.2699 0.2699
0.6561 1 1
0.0654 0.2553 0.4471
0.1408 1 1
0.7991 1 1
0.2611 1 0.5
0.2065 1 1
0.6248 0.5722 1
0.6335 0.3969 0.7121
0.5268 1 1
0.2066 0.2699 0.2699
0.5174 1 1
0.4472 1 1
0.0466 0.2974 0.3565
1.2039 1 1
1.1016 1 1
0.1945 1 1
0.2066 0.2699 0.2699
0.1087 1 0.5
0.1948 0.6868 1
0.2635 1 1
0.1939 1 1
0.6864 0.3207 0.6662
0.0663 0.5022 0.8786
0.0698 0.3953 0.9513
0.8874 0.258 1
0.9871 0.7312 1
0.5454 1 1
0.2066 0.2699 0.2699
0.2066 0.2699 0.2699
0.9221 1 1
0.3217 1 1
0.3856 1 1
0.2043 1 1
0.6248 0.5722 1
0.1289 0.2609 1
0.6335 0.3305 0.9532
0.6561 1 1
0.6864 0.3207 0.6662
0.0778 1 0.5
0.0681 0.3618 1
0.7209 1 1
0.0466 0.2974 0.3565
0.0679 0.2698 0.2818
0.6248 0.5722 1
0.2066 0.2699 0.2699
0.2577 0.9343 1
0.1357 0.3277 0.9848
0.1266 0.9305 1
0.1986 1 1
0.5854 1 1
0.0658 0.2714 0.983
0.1987 0.3701 0.3701
0.2066 0.2699 0.2699
0.0622 1 1
0.2066 0.2699 0.2699
0.0642 0.3841 0.953
0.1363 0.5022 1
0.2066 0.2699 0.2699
0.2066 0.2699 0.2699
0.1987 0.3701 0.3701
0.2066 0.2699 0.2699
0.0662 0.5 0.5
0.2066 0.2699 0.2699
0.1294 0.3006 0.5
0.0698 0.3953 0.9513
0.1322 1 1
0.2012 1 1
0.1354 0.628 1
1.0473 1 1
0.0652 0.3581 0.8022
0.0624 0.2958 0.2954
0.07 0.7425 0.7425
0.0778 0.9295 1
0.1987 0.3701 0.3701
0.6561 1 1
0.1918 0.2719 1
1.0441 1 1
0.6427 1 1
0.2066 0.2699 0.2699
0.6248 0.5722 1
0.9342 0.329 1
0.0778 0.5 0.5
0.0646 0.4052 0.9533
0.2571 0.2541 1
0.2066 0.2699 0.2699
0.5454 1 1
0.5601 1 1
0.1922 1 1
0.2686 0.6368 1
0.3206 1 1
0.0634 0.3005 0.9486
1.0207 1 1
0.2611 1 1
0.07 0.7425 0.7425
0.0358 0.4629 0.8441
0.1073 0.3084 0.3081
0.2758 0.7824 1
0.2066 0.2699 0.2699
0.1922 0.3016 0.7073
0.1925 1 1
0.854 1 1
0.2066 0.2699 0.2699
0.3217 1 1
0.2589 0.888 0.5
0.2638 1 0.5
1.0333 1 1
0.0778 1 0.5
0.2066 0.2699 0.2699
0.1939 1 1
0.0633 0.4624 1
0.5903 1 1
0.0778 0.4729 1
0.2066 0.2699 0.2699
0.256 1 0.5
0.0652 0.435 0.4347
0.2708 0.9647 1
0.0782 0.287 0.2897
0.2742 0.9992 1
0.0778 0.6011 0.9379
0.9414 1 1
0.1879 0.6673 1
1.0577 1 1
0.6864 0.3207 0.6662
0.0624 0.2958 0.2954
0.6517 1 1
0.6561 1 1
0.2066 0.2699 0.2699
0.2066 0.2699 0.2699
0.0672 0.4582 1
0.0637 0.387 0.4588
0.2066 0.2699 0.2699
0.2066 0.2699 0.2699
0.0625 0.75 1
0.6248 0.5722 1
0.2066 0.2699 0.2699
0.1935 0.7907 1
0.0679 0.2698 0.2818
0.6248 0.5722 1
0.0628 0.7711 0.5
0.2587 0.2544 1
0.1916 0.788 1
0.2043 1 1
0.0723 0.5191 1
0.2066 0.2699 0.2699
0.2025 1 1
0.6561 1 1
0.5454 1 1
0.0635 0.3805 1
0.1087 0.2768 0.2905
0.0635 0.878 1
0.0635 0.5295 1
0.8658 0.2918 0.3261
0.1921 0.336 1
0.2066 0.2699 0.2699
0.0752 1 1
0.1268 0.9186 0.9186
0.2635 0.5184 1
0.9133 1 1
0.0421 0.7177 1
0.1265 1 1
0.6864 0.3207 0.6662
0.0633 0.3997 1
0.9523 1 1
0.0683 0.7211 1
0.0625 0.7524 1
0.0756 1 1
0.9542 1 1
0.0654 0.5584 1
0.652 1 1
0.1035 0.351 1
0.0778 1 0.5
0.2066 0.2699 0.2699
0.8555 1 1
0.056 1 1
0.0778 0.5 0.5
0.6248 0.5722 1
0.0654 0.5 0.5
0.6248 0.5722 1
0.9342 0.329 1
0.0707 0.4151 0.5
0.5903 1 1
0.1087 1 0.5
0.0645 0.6738 1
0.6561 1 1
0.2066 0.2699 0.2699
0.2066 0.2699 0.2699
1.0207 1 1
0.0687 1 1
0.6554 0.4737 0.4737
0.0627 1 0.5
0.0698 0.3953 0.9513
0.0622 1 1
0.0577 0.3428 0.6235
0.0665 0.3115 1
0.0703 0.3227 1
0.0637 0.387 0.4588
0.0476 1 1
0.2066 0.2699 0.2699
0.1916 0.788 1
0.2581 0.7032 1
0.2066 0.2699 0.2699
0.8821 1 1
0.1356 0.4925 1
0.0682 0.4152 1
1.0345 1 1
1.0334 1 1
0.1363 0.5022 1
0.3254 1 1
0.1278 1 1
0.0778 1 0.5
0.0721 1 1
0.656 1 1
0.2066 0.2699 0.2699
0.1073 0.3084 0.3081
0.5904 1 1
0.6582 1 1
0.2043 1 1
0.0853 1 1
0.0666 0.9171 0.9171
0.2066 0.2699 0.2699
0.2066 0.2699 0.2699
0.6864 0.3207 0.6662
0.0666 0.5009 0.9923
0.07 0.7425 0.7425
0.6295 1 0.5
0.07 0.7425 0.7425
0.6864 0.3207 0.6662
0.0622 0.8038 1
0.6864 0.3207 0.6662
0.0672 0.2676 0.9683
0.2066 0.2699 0.2699
0.2066 0.2699 0.2699
0.2066 0.2699 0.2699
0.2066 0.2699 0.2699
0.2449 1 1
0.2066 0.2699 0.2699
0.9235 1 1
0.0625 0.3466 1
0.0778 0.298 1
0.2066 0.2699 0.2699
0.2603 0.7676 1
0.6248 0.5722 1
0.2096 1 1
0.0778 0.7476 1
0.724 1 1
0.1035 0.351 1
0.0721 1 1
0.0666 0.5009 0.9923
0.9235 1 1
0.0628 0.8263 1
0.0778 0.9734 0.9734
0.2066 0.2699 0.2699
0.6441 1 1
0.1265 1 1
0.2066 0.2699 0.2699
0.0661 1 1
0.1289 0.2609 1
0.2066 0.2699 0.2699
0.0778 0.9685 1
0.1087 0.2768 0.2905
0.1962 1 1
0.1344 0.3118 1
0.0634 0.3005 0.9486
0.6864 0.3207 0.6662
0.2767 1 1
0.2066 0.2699 0.2699
0.3217 1 1
0.8152 1 1
0.2066 0.2699 0.2699
0.0624 0.2527 0.9259
0.9481 1 1
0.0652 0.435 0.4347
0.0472 0.6899 1
0.2066 0.2699 0.2699
0.1918 0.2719 1
0.0521 1 1
0.5746 1 1
0.7763 1 1
0.2066 0.2699 0.2699
0.7329 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_110860 (Schistosoma mansoni), Replicative DNA helicase
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