Detailed view for LmjF.11.1100

Basic information

TDR Targets ID: 28984
Leishmania major, lanosterol 14-alpha-demethylase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.2281 | Length (AA): 479 | MW (Da): 54165 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00067   Cytochrome P450

Gene Ontology

Mouse over links to read term descriptions.
GO:0016705   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  
GO:0020037   heme binding  
GO:0009055   electron carrier activity  
GO:0005506   iron ion binding  
GO:0004497   monooxygenase activity  
GO:0055114   oxidation reduction  

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
24 476 1t2b (A) 11 400 15.00 0 1 0.99 -0.42
29 475 1z10 (A) 30 494 18.00 0 1 1.24 -1.43
32 476 1x8v (A) 6 449 30.00 0 1 1.32 -0.89
29 476 4c27 (A) 29 477 77.00 0 1 1.91568 -1.39
30 476 3l4d (A) 30 476 97.00 0 1 2.13639 -1.4

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 3L4D:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile metacyclic. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile amastigotes. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_129288)

Species Accession Gene Product
Arabidopsis thaliana AT1G11680   sterol 14-demethylase
Candida albicans CaO19.8538   cytochrome P450 lanosterol 14-alpha -demethylase
Candida albicans CaO19.922   cytochrome P450 lanosterol 14-alpha -demethylase
Dictyostelium discoideum DDB_G0279403   cytochrome P450 family protein
Homo sapiens ENSG00000001630   cytochrome P450, family 51, subfamily A, polypeptide 1
Leishmania braziliensis LbrM.11.0880   lanosterol 14-alpha-demethylase, putative
Leishmania donovani LdBPK_111100.1   Lanosterol 14-alpha demethylase
Leishmania infantum LinJ.11.1100   lanosterol 14-alpha-demethylase, putative
Leishmania major LmjF.11.1100   lanosterol 14-alpha-demethylase, putative
Leishmania mexicana LmxM.11.1100   lanosterol 14-alpha-demethylase, putative
Mus musculus ENSMUSG00000001467   cytochrome P450, family 51
Mycobacterium tuberculosis Rv0764c   Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)
Mycobacterium ulcerans MUL_0473   cytochrome P450 51B1 Cyp51B1
Oryza sativa 4350614   Os11g0525200
Oryza sativa 4338097   Os05g0211100
Saccharomyces cerevisiae YHR007C   sterol 14-demethylase
Trypanosoma brucei gambiense Tbg972.11.7000   lanosterol 14-alpha-demethylase,cytochrome P450 51A1, putative
Trypanosoma brucei Tb927.11.6210   Lanosterol 14-alpha demethylase
Trypanosoma congolense TcIL3000.11.6740   Lanosterol 14-alpha demethylase
Trypanosoma cruzi TcCLB.510101.50   Lanosterol 14-alpha demethylase
Trypanosoma cruzi TcCLB.506297.260   Lanosterol 14-alpha demethylase

Essentiality

LmjF.11.1100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu779 Mycobacterium tuberculosis non-essential nmpdr
Tb11.02.4080 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.4080 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.4080 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.4080 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
YHR007C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania mexicana 6333   55811   68461  
Annotator: aaronjr@u.washington.edu. Comment: chemical inhibition with sterol 14-α-demethylase (1.14.13.70) inhibitors leads to slow growth of Leishmania sp. in cell assay; inhibitor D0870. References: 9124841
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania braziliensis 6333   55811   68461  
Annotator: aaronjr@u.washington.edu. Comment: chemical inhibition with sterol 14-α-demethylase (1.14.13.70) inhibitors leads to slow growth of Leishmania sp. in cell assay; inhibitor D0870. References: 9124841
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania mexicana 27007   55811  
Annotator: aaronjr@u.washington.edu. Comment: chemical inhibition with sterol 14-α-demethylase (1.14.13.70) inhibitors leads to slow growth of Leishmania sp. in cell assay; . References: 12739804
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 27007   55811  
Annotator: aaronjr@u.washington.edu. Comment: chemical inhibition with sterol 14-α-demethylase (1.14.13.70) inhibitors leads to slow growth of Leishmania sp. in cell assay; . References: 12739804
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania major 27007   55811  
Annotator: aaronjr@u.washington.edu. Comment: chemical inhibition with sterol 14-α-demethylase (1.14.13.70) inhibitors leads to slow growth of Leishmania sp. in cell assay; . References: 12739804
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania mexicana 6333   68461  
Annotator: aaronjr@u.washington.edu. Comment: Drug: (sodium stibogluconate) 16037-91-5. chemical inhibition with sterol 14-α-demethylase (1.14.13.70) inhibitors leads to slow growth of Leishmania sp. in vivo (human); Q2HWD2_LEIAM; . References: 1311351
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) host (GO:0018995) Leishmania braziliensis 6333   68461  
Annotator: aaronjr@u.washington.edu. Comment: Drug: (sodium stibogluconate) 16037-91-5. chemical inhibition with sterol 14-α-demethylase (1.14.13.70) inhibitors leads to slow growth of Leishmania sp. in vivo (human); Q2HWD2_LEIAM; . References: 1311351
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) host (GO:0018995) Leishmania mexicana 6333   68461  
Annotator: aaronjr@u.washington.edu. Comment: Drug: (sodium stibogluconate) 16037-91-5. chemical inhibition with sterol 14-α-demethylase (1.14.13.70) inhibitors leads to slow growth of Leishmania sp. in vivo (human); Q2HWD2_LEIAM; . References: 1311351
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania braziliensis 6333   68461  
Annotator: aaronjr@u.washington.edu. Comment: Drug: (sodium stibogluconate) 16037-91-5. chemical inhibition with sterol 14-α-demethylase (1.14.13.70) inhibitors leads to slow growth of Leishmania sp. in vivo (human); Q2HWD2_LEIAM; . References: 1311351
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania amazonensis No drug identifiers listed for this gene.
Annotator: aaronjr@u.washington.edu. Comment: Drug: (SCH 56592 posaconazole) 171228-49-2. chemical inhibition with sterol 14-α-demethylase (1.14.13.70) inhibitors leads to slow growth of Leishmania sp. in vivo (balb/c mouse); Q2HWD2_LEIAM; . References: 10582881
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) host (GO:0018995) Leishmania donovani No drug identifiers listed for this gene.
Annotator: aaronjr@u.washington.edu. Comment: Drug: (SCH 56592 posaconazole) 171228-49-2. chemical inhibition with sterol 14-α-demethylase (1.14.13.70) inhibitors leads to slow growth of Leishmania sp. in vivo (balb/c mouse); Q2HWD2_LEIAM; . References: 10582881
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) host (GO:0018995) Leishmania amazonensis No drug identifiers listed for this gene.
Annotator: aaronjr@u.washington.edu. Comment: Drug: (SCH 56592 posaconazole) 171228-49-2. chemical inhibition with sterol 14-α-demethylase (1.14.13.70) inhibitors leads to slow growth of Leishmania sp. in vivo (balb/c mouse); Q2HWD2_LEIAM; . References: 10582881
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania donovani No drug identifiers listed for this gene.
Annotator: aaronjr@u.washington.edu. Comment: Drug: (SCH 56592 posaconazole) 171228-49-2. chemical inhibition with sterol 14-α-demethylase (1.14.13.70) inhibitors leads to slow growth of Leishmania sp. in vivo (balb/c mouse); Q2HWD2_LEIAM; . References: 10582881
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) host (GO:0018995) Leishmania major 27007  
Annotator: aaronjr@u.washington.edu. Comment: chemical inhibition with sterol 14-α-demethylase (1.14.13.70) inhibitors leads to slow growth of Leishmania sp. in vivo (human); Q2HWD2_LEIAM; . References: 16445420
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania major 27007  
Annotator: aaronjr@u.washington.edu. Comment: chemical inhibition with sterol 14-α-demethylase (1.14.13.70) inhibitors leads to slow growth of Leishmania sp. in vivo (human); Q2HWD2_LEIAM; . References: 16445420

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

  • Validation: inhibition during in vitro culture
  • annotated by: aaronjr@u.washington.edu.
  • References: 12739804 9124841

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.8

Known modulators for this target

Compound Source Reference
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) Compounds References
Sorghum bicolor Obtusifoliol 14-alpha demethylase Compounds References
Neosartorya fumigata 14-alpha sterol demethylase Compounds References
Trypanosoma cruzi Lanosterol 14-alpha demethylase Compounds References
Penicillium digitatum Cytochrome P450 14alpha-demethylase Compounds References
Trypanosoma cruzi Lanosterol 14-alpha demethylase Compounds References
Homo sapiens cytochrome P450, family 51, subfamily A, polypeptide 1 Compounds References
Penicillium digitatum P450 sterol 14-alpha-demethylase Compounds References
Rattus norvegicus Cytochrome P450 51 Compounds References
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSCA1100) (Aspergillus fumigatus) 14-alpha sterol demethylase Cyp51A Compounds References
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) Lanosterol 14-alpha demethylase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0023 0.5 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0007 0.5 0.5
0.0184 0.3352 0.5613
0.000396385 0.5 0.5
0.0103 0.4147 0.4139
0.0062 0.5 0.5
0.0154 0.3211 1
0.0267 0.27 0
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0163 0.4703 1
0.0202 0.2702 0.5108
0.0046 0.6591 1
0.00451124 0.405669 0
0.0462 0.6723 1
0.0166 0.2667 1
0.0159 0.2641 1
0.0011 0.5 0.5
0.0048 0.6597 0.6597
0.0046 0.2608 0.1859
0.1036 0.6182 1
0.0284 0.2924 0.419
0.0051 0.4977 0.5
0.0018 0.2637 0.5
0.0119 0.4458 0
0.0068 1 1
0.0513 0.3362 0.9086
0.00213675 0.269186 0
0.0183 0.6299 1
0.0361 0.4283 1
0.0151 0.4334 0.5
0.0018 1 0.5
0.0083 0.5 0.5
0.0004 0.5 0.5
0.0286 1 1
0.0044 0.2627 0.057
0.00184047 0.269186 0
0.036 0.2841 0.4156
0.0004 0.5 0.5
0.0048 1 0.5
0.007 1 1
0.0087 1 1
0.0019 0.271 0
0.0004 0.5 0.5
0.0051 0.3758 1
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0004 0.5 0.5
0.0075 0.2816 0.3367
0.00505219 0.5 0.5
0.000218985 0.5 0.5
0.1115 0.6699 0.5
0.0004 0.5 0.5
0.0291 0.2657 0.2657
0.0069 0.2847 0.4473
0.0639 0.6982 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0293 0.3401 0.5
0.0007 0.5 0.5
0.0448 0.2736 0.91
0.0106 0.2751 0.2411
0.0087 1 1
0.000376403 0.5 0.5
0.0696 0.8858 1
0.0042 0.5 0.5
0.03 0.3516 1
0.0092 1 1
0.0164 0.481 0.7545
0.0671 0.5362 1
0.0003 0.5 0.5
0.0004 0.5 0.5
0.0862 0.5975 1
0.0047 0.6638 0.6638
0.0171 0.9894 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0078 1 0.5
0.0045 0.5 0.5
0.1602 0.7591 1
0.1002 0.8022 1
0.0218 0.3052 1
0.0332 0.8911 1
0.0108 0.2733 0.2665
0.1062 0.8017 0.9656
0.062 0.6312 1
0.0046 0.5 0.5
0.0094 0.2887 0.445
0.0324 0.2701 0.2701
0.0018 0.3602 0.5
0.0065 1 1
0.0168 0.259 1
0.0625 0.8811 1
0.0146 0.4079 1
0.0023 0.5 0.5
0.0033 0.2605 0.5
0.0073 0.5 0.5
0.0165 0.438 1
0.1465 0.3142 1
0.0004 0.5 0.5
0.0058 0.5 0.5
0.0055 0.2887 0.3593
0.0688 0.8671 1
0.0049 0.293 0.6642
0.0047 0.6638 0.6638
0.0503 0.7068 1
0.0008 0.5 0.5
0.0074 1 1
0.0711 0.5076 1
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0012 0.5 0.5
0.0155 0.2557 1
0.006 0.2795 0.4558
0.0072 0.3109 1
0.0331 0.3985 0.9211
0.0329 0.5818 0.5
0.0015 0.5 0.5
0.0063 0.5 0.5
0.0033 0.5 0.5
0.0153 0.5625 0.5
0.002 1 0.5
0.0018 0.2876 0.2876
0.003 0.3271 0.3271
0.0155 0.3457 1
0.0146 0.6654 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0003 0.5 0.5
0.005 1 1
0.0047 0.6689 0.6689
0.0996 0.802 1
0.0037 0.4283 0
0.0336 0.7111 1
0.0122 0.4249 0.4197
0.0011 0.5 0.5
0.0065 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0036 1 0.5
0.0078 0.3003 0.8731
0.0477 0.4965 1
0.0008 0.3317 0.2745
0.0747 0.7807 1
0.0012 1 0.5
0.0067 0.5 0.5
0.004 1 0.5
0.0183 0.2531 1
0.099 0.802 1
0.0159 0.2641 1
0.0004 0.5 0.5
0.0146 0.2926 1
0.0171 0.403 1
0.0312 0.3381 1
0.0303 0.2816 0.8375
0.0004 0.5 0.5
0.0093 0.3481 0.7056
0.1465 0.3142 1
0.0004 0.5 0.5
0.0217 0.2742 0
0.0004 0.5 0.5
0.0194 0.2564 1
0.016 0.2629 1
0.00777519 0.280873 0.259976
0.0702 0.3738 0.3738
0.0322 0.4757 1
0.0357 0.259 0.6203
0.0004 0.5 0.5
0.035 0.4558 1
0.0004 0.5 0.5
0.0124 0.2696 0.2696
0.0004 1 0.5
0.0331 0.3985 0.9211
0.0352 0.4849 1
0.0157 0.257 1
0.0004 0.5 0.5
0.0133 0.256 0.2574
0.0083 1 0.5
0.018 0.2527 1
0.0303 0.2816 0.8375
0.0004 0.5 0.5
0.0165 0.7594 1
0.1101 0.802 1
0.0004 0.5 0.5
0.0446 0.6487 1
0.0038 0.5102 1
0.0057 0.2766 1
0.0004 0.5 0.5
0.0018 0.5 0.5
0.0019 0.5 0.5
0.0032 0.5 0.5
0.0912 0.5939 1
0.1465 0.3142 1
0.0302 0.3303 1
0.0306412 1 1
0.0007 0.5 0.5
0.0007 0.5 0.5
0.0486 0.9107 0.9107
0.0023 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0154 0.2804 1
0.0004 0.5 0.5
0.0677 0.4744 1
0.0352 0.4849 1
0.0688 0.8671 1
0.0155 0.3457 1
0.0228 0.2829 0
0.0747 0.7807 1
0.0011 0.5 0.5
0.0019 0.5 0.5
0.1602 0.7591 1
0.1602 0.7591 1
0.016 0.2681 1
0.0513 0.3362 0.9086
0.015 0.2827 0.5383
0.1465 0.3142 1
0.0071 0.3514 0.5
0.0249 0.3082 0.6599
0.0213 0.3032 1
0.0672 0.886 1
0.0051 0.5 0.5
0.0314 0.2621 1
0.1153 0.6373 1
0.0335 0.3224 0.5
0.0032 1 0.5
0.0346 0.2559 0.4077
0.0284 0.2924 0.419
0.0075 0.3265 0.149
0.0157 0.2757 1
0.024 0.2897 0.7018
0.0348 0.7922 0.9124
0.0163 0.5876 0.8351
0.0004 0.5 0.5
0.015 0.7874 0.5
0.0003 0.5 0.5
0.0063 0.3886 0
0.0015 0.5 0.5
0.015 0.2827 0.5383
0.0054 1 1
0.0018 0.5 0.5
0.0316 0.2652 0.2784
0.0162 0.2618 1
0.0004 0.5 0.5
0.0062 0.2905 0.4453
0.0217 0.8044 1
0.0023 0.9674 0.5
0.004 1 1
0.0004 1 0.5
0.0151 0.5924 0.5
0.0191 0.2612 1
0.0083 0.6735 0.5
0.0725 0.8863 1
0.0004 0.5 0.5
0.0403 0.6854 1
0.0004 0.5 0.5
0.0157 0.3541 0
0.0198 0.2637 1
0.0167 0.259 1
0.0152 0.3281 0.5
0.0028 0.5 0.5
0.0462 0.643 0.911
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0048 0.6634 0.6634
0.0172 0.2609 1
0.0553 0.8015 0.9078
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0151 0.2567 1
0.0512 0.7191 1
0.0021 0.4036 0
0.0056 0.3577 1
0.037 0.7605 1
0.0314 0.256 0.8612
0.0163 0.259 1
0.0053 1 1
0.0012 0.5 0.5
0.0004 0.5 0.5
0.004 1 0.5
0.0004 0.5 0.5
0.047 0.9106 0.9095
0.0004 0.5 0.5
0.0127 0.5337 0
0.0004 0.5 0.5
0.0158 0.4905 0.5
0.0004 0.5 0.5
0.0893 0.5804 1
0.0183 0.2531 1
0.0443 0.3118 0.6583
0.0004 0.5 0.5
0.0036 0.5 0.5
0.0158 0.254 1
0.0004 0.5 0.5
0.0079 0.2909 0.3548
0.008 1 0.5
0.0004 0.5 0.5
0.0388 0.2772 0.2713
0.0075 1 1
0.0033 0.5 0.5
0.0164 0.3784 0
0.0702 0.3738 0.3738
0.0004 0.5 0.5
0.0069 0.5 0.5
0.1602 0.7591 1
0.0022 0.5 0.5
0.0007 0.5 0.5
0.0752 0.6388 1
0.0672 0.886 1
0.0403 0.6854 1
0.0004 0.5 0.5
0.0071 0.5 0.5
0.0348 0.3555 1
0.0197 0.6846 0
0.0004 0.5 0.5
0.033112 0.607222 1
0.0301 0.3613 1
0.0348 0.7922 0.9124
0.1148 0.2878 1
0.0011 1 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0084 0.5 0.5
0.0157 0.5824 0
0.0173 0.302 1
0.0102 0.3061 0.3937
0.0605 0.2711 1
0.0004 0.5 0.5
0.0012 0.5 0.5
0.0284 0.2726 0.2726
0.0011 0.5 0.5
0.0007 0.5 0.5
0.0026 0.5 0.5
0.0155 0.253 1
0.0183 0.403 0.5968
0.0004 0.5 0.5
0.033 0.3723 0.5186
0.1465 0.3142 1
0.0004 0.5 0.5
0.003 0.3514 0.5
0.0361 0.4283 1
0.0364 0.3589 1
0.0148 0.2542 1
0.0268 0.2982 0.6893
0.0203 0.2689 0.2582
0.0069 1 1
0.015 0.3435 0
0.0071 0.5 0.5
0.008 0.5 0.5
0.0181 0.3169 0.5
0.0663 0.8858 1
0.0383 0.3887 1
0.026 0.251 0.2723
0.008 0.2582 0.6941
0.007 0.5713 0.5
0.0389 0.7819 1
0.015 0.3152 1
0.1465 0.3142 1
0.005 0.5 0.5
0.0004 0.5 0.5
0.0626 0.5952 1
0.0168 0.2591 1
0.0386 0.4085 1
0.0004 0.5 0.5
0.01 0.5 0.5
0.0004 0.5 0.5
0.0066 1 1
0.0004 0.5 0.5
0.031 0.6928 1
0.0509833 1 1
0.0038 0.5 0.5
0.0345 0.435 0.5
0.0059 0.6064 0.5
0.0184 0.3508 0
0.0026 0.5 0.5
0.0028 0.5 0.5
0.0153 0.3084 0.7961
0.0351 0.8286 0.5
0.0004 0.5 0.5
0.0542 0.9106 0.8739
0.1148 0.2878 1
0.0372 0.7857 1
0.0023 1 0.5
0.0081 0.5 0.5
0.0054 0.5 0.5
0.0341 0.2689 0.2287
0.0018 0.5 0.5
0.1465 0.3142 1
0.0004 0.5 0.5
0.007 1 1
0.0626 0.779 0.5
0.037851 1 1
0.0019 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.1068 0.8021 1
0.002 0.5 0.5
0.0376 0.4909 1
0.0721 0.4281 1
0.0383 0.3887 1
0.0012 0.5 0.5
0.0012 0.5 0.5
0.0008 0.5 0.5
0.0153 0.9262 0.5
0.0674 0.8786 1
0.0092 0.467 0
0.0635 0.4849 1
0.0462 0.6723 1
0.0387 0.7903 1
0.0004 0.5 0.5
0.0619 0.5956 1
0.0027 1 1
0.0059 0.6064 0.5
0.0114 1 1
0.0378 0.709 1
0.000376403 0.5 0.5
0.0156 0.2557 1
0.0004 0.5 0.5
0.0146 0.6069 0.5
0.0049 0.6682 0.6682
0.0632 0.2978 1
0.0004 0.5 0.5
0.000218985 0.5 0.5
0.0386 0.4085 1
0.0004 0.5 0.5
0.0681 0.8857 1
0.0881 0.4603 1
0.0149 0.8285 1
0.0051 0.5 0.5
0.0166 0.7812 1
0.0297 0.2564 1
0.1047 0.802 1
0.047 0.6203 0.9107
0.0366 0.7443 1
0.00139338 1 0.5
0.0004 0.5 0.5
0.033 0.602 1
0.0678 0.885 1
0.0736 0.8811 1
0.0063 0.5 0.5
0.016 0.2625 1
0.1131 0.299 1
0.0016 1 0.5
0.0004 0.5 0.5
0.0103 0.6953 0.898
0.0016 1 0.5
0.0068 0.4312 1
0.0035 0.4422 0.5
0.0775 0.7057 1
0.0007 0.5 0.5
0.0121 1 1
0.0314 0.2989 1
0.0297 0.6854 1
0.0018 0.5004 0
0.0358 0.5358 0.8182
0.0672 0.4583 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0098 0.4422 1
0.0152 0.3281 0.5
0.0004 0.5 0.5
0.0045 0.5 0.5
0.0624 0.8811 1
0.0063 0.2543 0.6677
0.0011 1 0.5
0.0368 0.2796 0.2661
0.025 0.2789 0
0.0314 0.2989 1
0.0159 0.2641 1
0.0004 0.5 0.5
0.0082 0.5 0.5
0.0038 1 0.5
0.0717 0.3119 1
0.0289 0.2916 0.389
0.0047 0.5 0.5
0.1074 0.802 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.015 0.7481 0.9651
0.0361 0.4283 1
0.0688 0.823 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.007 0.5 0.5
0.0032 1 0.5
0.0052 0.3769 0.5
0.0176 0.3425 0.4215
0.0004 0.5 0.5
0.0171 0.403 1
0.037 0.5474 0.9246
0.004 1 0.5
0.0067 0.5 0.5
0.0685 0.8856 1
0.0008 1 0.5
0.0195 0.6493 1
0.0015 0.5 0.5
0.0164 0.481 0.7545
0.007 0.3303 0.4717
0.0059 0.6064 0.5
0.0036 0.5 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0211 0.2733 0.3337
0.0323 0.2823 0.3349
0.0042 0.3378 0
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0082 0.5 0.5
0.0099 0.7062 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.047 0.9107 0.9107
0.0168 0.2591 1
0.0008 0.5 0.5
0.0153 0.3084 0.7961
0.0625 0.8808 1
0.0617 0.8811 1
0.0011 0.5 0.5
0.0338 0.5593 1
0.033 0.2943 0.5
0.0011 0.5 0.5
0.037 0.7605 1
0.1026 0.802 1
0.0158 0.2622 1
0.0164 0.2601 1
0.0193 0.2513 1
0.0154 0.3977 0.2788
0.0366 0.2672 0.4691
0.0157 0.732 1
0.0057 0.2766 1
0.1465 0.3142 1
0.0012 0.5 0.5
0.0004 0.5 0.5
0.1465 0.3142 1
0.0004 0.5 0.5
0.0157 0.2822 1
0.0353 0.4928 1
0.0004 0.5 0.5
0.0216 0.2583 0
0.00213675 0.269186 0
0.0004 0.5 0.5
0.0358 0.4134 1
0.0437 0.3909 0.4116
0.0004 0.5 0.5
0.034 0.2765 0
0.0004 0.5 0.5
0.0388 0.2772 0.2713
0.0082 0.5 0.5
0.0146 0.2926 1
0.0027 0.5 0.5
0.0193 0.311 0
0.0008 0.5 0.5
0.0033 0.5 0.5
0.0667 0.4457 1
0.0418 0.3088 0.5798
0.0004 0.5 0.5
0.0173 0.3858 0
0.0372 0.7857 1
0.0019 0.5 0.5
0.0008 0.5 0.5
0.0341 0.6337 1
0.0044 0.4237 0.2755
0.0526 0.9107 0.9107
0.0337 0.4679 1
0.0059 0.5 0.5
0.0045 0.5 0.5
0.0025 0.5 0.5
0.0246 0.2667 0.2667
0.0012 0.5 0.5
0.0759 0.358 1
0.0046 0.6591 1
0.0353 0.4928 1
0.0319 0.3153 0.5
0.0032 0.5 0.5
0.0366 0.3188 1
0.0153 0.2876 0.3948
0.0004 0.5 0.5
0.0029 0.36 0.5
0.018 0.2527 1
0.0605 0.2711 1
0.0641 0.5566 0.5558
0.0071 0.9628 0.5
0.0073 1 1
0.0137 0.271 0.2294
0.0028 0.2972 0.6218
0.0007 1 0.5
0.0162 0.2769 0.9552
0.0261 0.3093 0.6969
0.0326 0.2819 0
0.0026 0.5 0.5
0.0172 0.3036 0.9384
0.0167 0.2978 0
0.0189 0.5524 0
0.0182845 1 1
0.1031 0.802 1
0.005 0.2698 0
0.0018 0.5004 0
0.0022 0.3789 0.5
0.0316 0.3317 0.5
0.0625 0.8811 1
0.0011 0.5 0.5
0.0015 0.5 0.5
0.0052 0.2829 0.0114
0.0007 0.5 0.5
0.0183 0.9338 1
0.0185 0.2528 0
0.004 1 0.5
0.0008 0.5 0.5
0.0368 0.2796 0.2661
0.0338 0.5593 1
0.0235 0.3192 0.3992
0.1068 0.802 1
0.0146 0.2894 1
0.0004 0.5 0.5
0.0133 0.2787 0.264
0.0261 0.3093 0.6969
0.0111 0.3549 1
0.0066 0.5 0.5
0.0008 0.5 0.5
0.0086 0.5 0.5
0.0178 0.2674 1
0.0034 0.337 0.337
0.0002 0.5 0.5
0.004 0.5565 0.5565
0.0004 0.5 0.5
0.0065 0.3393 0
0.0162 0.2618 1
0.0119 0.5 0.5
0.0532 0.9106 0.9093
0.0168 0.259 0.3448
0.1465 0.3142 1
0.0065 0.5 0.5
0.0386 0.4085 1
0.015 0.4728 0.7677
0.0004 0.5 0.5
0.0063 0.4653 0.5
0.0011 0.5 0.5
0.0059 0.6064 0.5
0.0033 0.3348 0.3348
0.0022 0.5 0.5
0.1721 0.4843 1
0.0752 0.802 1
0.0759 0.358 1
0.0187 0.3027 1
0.0641 0.5566 0.5558
0.0018 0.5 0.5
0.0553 0.8015 0.9078
0.0004 1 0.5
0.0004 0.5 0.5
0.0046 0.5 0.5
0.026 0.251 0.2723
0.0336 0.2847 0
0.0042 1 1
0.0151 0.9306 0
0.0056 0.6399 1
0.0341 0.6337 1
0.0055 0.5 0.5
0.1043 0.802 1
0.0073 1 1
0.0337 0.6068 0.5
0.033 0.3723 0.5186
0.0044 0.6112 0.6112
0.0022 0.3489 0.5
0.0004 0.5 0.5
0.0166 0.2888 0
0.0077 0.5 0.5
0.1465 0.3142 1
0.00213675 0.269186 0
0.033 0.3723 0.5186
0.037 0.5474 0.9246
0.0036 0.4353 0.4353
0.0569 0.2624 0.4601
0.0372 0.8285 0.8245
0.0032 0.5 0.5
0.0067 0.5 0.5
0.03 0.8036 0.5
0.0165 0.3847 1
0.0174 0.5119 1
0.0322 0.4757 1
0.0711 0.5076 1
0.0004 0.5 0.5
0.0093 0.5 0.5
0.0639 0.7064 1
0.0052 0.3825 1
0.1301 0.2826 1
0.0337 0.6068 0.5
0.06 0.7255 0.5
0.0004 0.5 0.5
0.0301 0.3324 0.9138
0.0004 0.5 0.5
0.0358 0.4134 1
0.017566 0.5 0.5
0.0011 1 0.5
0.0486 0.9107 0.9107
0.0759 0.358 1
0.0375 0.3534 1
0.0084 1 0.5
0.0119 0.4458 0
0.0076 1 1
0.0358 0.4134 1
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0294 0.2859 1
0.0213 0.3032 1
0.0071 0.2928 0.4724
0.0029 0.5 0.5
0.0072 1 1
0.0008 0.5 0.5
0.0448 0.7929 0.8739
0.0148 0.2848 0.4176
0.0004 0.5 0.5
0.0532 0.9106 0.9093
0.0486 0.9107 0.9107
0.0094 0.5 0.5
0.0174 0.2937 0
0.0316 0.2822 1
0.0027 1 0.5
0.0081 0.5 0.5
0.0004 0.5 0.5
0.0084 0.3462 0.8861
0.0004 0.5 0.5
0.0173 0.3457 0
0.0146 0.2926 1
0.0004 0.5 0.5
0.0824 0.4047 1
0.0569 0.2624 0.4601
0.0194 0.2538 1
0.0316 0.2652 0.2784
0.0004 0.5 0.5
0.0324 0.3254 1
0.0148 0.489 1
0.0004 0.5 0.5
0.0059 0.5 0.5
0.1465 0.3142 1
0.0378 0.709 1
0.0154 0.3977 0.2788
0.0004 0.5 0.5
0.0297 0.2564 1
0.0725 0.8863 1
0.0681 0.8857 1
0.0008 0.3317 0.2745
0.0152 0.3281 0.5
0.0004 0.5 0.5
0.0012 0.5 0.5
0.0158 0.26 1
0.1068 0.802 1
0.0371 0.7931 1
0.0072 1 1
0.0296 0.3528 0.5
0.0004 0.5 0.5
0.0647 0.8811 1
0.0332 0.8911 1
0.0703 0.2998 1
0.0151 0.4822 1
0.0004 0.5 0.5
0.0173 0.2618 1
0.0068 0.5 0.5
0.0261 0.3093 0.6969
0.0004 0.5 0.5
0.0592 0.8811 1
0.037 0.7973 1
0.0004 0.5 0.5
0.0104 0.5 0.5
0.0004 0.5 0.5
0.0323 0.3673 0.849
0.0477 0.4965 1
0.0654 0.3016 1
0.0314 0.2989 1
0.0641 0.5566 0.5558
0.0513 0.9107 0.9107
0.0376 0.8532 1
0.0361 0.2704 0
0.0007 1 0.5
0.0364 0.3589 1
0.0235 0.2812 0.4163
0.037 0.5474 0.9246
0.0004 0.5 0.5
0.0067 0.5 0.5
0.0156 0.4244 0.4244
0.0019 0.2756 0.5
0.0015 0.5 0.5
0.1465 0.3142 1
0.0166 0.5366 0
0.0701 0.3075 1
0.0361 0.4283 1
0.0194 0.2564 1
0.0168 0.2601 1
0.00213675 0.269186 0
0.049 0.8862 1
0.0004 0.5 0.5
0.0038 0.525 0
0.0297 0.333 0.5
0.0314 0.2989 1
0.0114 1 1
0.0004 0.5 0.5
0.0641 0.5566 0.5558
0.0501 0.2598 1
0.0167 0.2616 1
0.0004 0.5 0.5
0.0262 0.3083 0.7125
0.0019 0.271 0
0.005 0.3622 0.5
0.0099 0.7122 0.5
0.0029 1 1
0.008 0.2556 0.84
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0625 0.8808 1
0.0004 0.5 0.5
0.0294 0.9754 0.9752
0.0692 0.8857 1
0.0158 0.2725 1
0.0703 0.2998 1
0.0157 0.3856 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.041 0.3921 0.4129
0.0011 0.5 0.5
0.0011 0.5 0.5
0.0118 0.3485 0
0.1062 0.8017 0.9656
0.0004 0.5 0.5
0.0025 0.5 0.5
0.0145 0.7126 0.5
0.0014 0.5 0.5
0.0011 0.5 0.5
0.0156 0.2557 1
0.0016 0.5 0.5
0.0004 0.5 0.5
0.0319 0.3153 0.5
0.0348 0.7922 0.9124
0.0912 0.5939 1
0.0364 0.3589 1
0.00109509 1 0.5
0.1465 0.3142 1
0.0666 0.4778 0.9349
0.0167 0.259 1
0.0037 0.2694 1
0.1089 0.802 1
0.0759 0.358 1
0.0446 0.6487 1
0.0091 0.2951 0.4172
0.1602 0.7591 1
0.0314 0.2641 1
0.0378 0.709 1
0.0103 1 0.5
0.0021 0.5 0.5
0.0018 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

5 literature references were collected for this gene.

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Gene identifier LmjF.11.1100 (Leishmania major), lanosterol 14-alpha-demethylase, putative
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