Detailed view for Smp_160620.2

Basic information

TDR Targets ID: 290368
Schistosoma mansoni, subfamily M12B unassigned peptidase (M12 family)
Source Database / ID:  GeneDB

pI: 8.1464 | Length (AA): 839 | MW (Da): 93144 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00200   Disintegrin
PF01421   Reprolysin (M12B) family zinc metalloprotease
PF08516   ADAM cysteine-rich

Gene Ontology

Mouse over links to read term descriptions.
GO:0008237   metallopeptidase activity  
GO:0004222   metalloendopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 443 3dsl (A) 118 417 38.00 0 1 0.333318 1.75
2 85 1qua (A) 115 196 39.00 0.0000037 0.54 0.494619 0.21
22 89 4q1l (A) 134 202 38.00 0.000046 0.53 0.475549 -0.1
25 469 3g5c (A) 367 703 37.00 0 1 0.400893 1.51
25 69 1yp1 (A) 137 181 47.00 0.017 0.97 0.560135 0.12
165 258 1l3x (A) 1 71 49.00 0.00000000012 1 0.305538 0.68
167 254 4r5r (A) 1 65 51.00 0.00000049 1 0.294387 0.22
430 481 2gy5 (A) 302 344 42.00 0.56 1 0.334479 0.39
614 715 2vuo (A) 336 441 27.00 0.61 0.32 0.335073 -0.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129483)

Species Accession Gene Product
Brugia malayi Bm1_53050   Reprolysin
Caenorhabditis elegans CELE_C04A11.4   Protein ADM-2
Drosophila melanogaster Dmel_CG7649   CG7649 gene product from transcript CG7649-RC
Echinococcus granulosus EgrG_000832900   subfamily M12B unassigned peptidase
Echinococcus multilocularis EmuJ_000832900   subfamily M12B unassigned peptidase
Homo sapiens ENSG00000148848   ADAM metallopeptidase domain 12
Homo sapiens ENSG00000149451   ADAM metallopeptidase domain 33
Homo sapiens ENSG00000135074   ADAM metallopeptidase domain 19
Loa Loa (eye worm) LOAG_08637   reprolysin
Mus musculus ENSMUSG00000054555   a disintegrin and metallopeptidase domain 12 (meltrin alpha)
Mus musculus ENSMUSG00000027318   a disintegrin and metallopeptidase domain 33
Mus musculus ENSMUSG00000011256   a disintegrin and metallopeptidase domain 19 (meltrin beta)
Schistosoma japonicum Sjp_0042280   ko:K08616 a disintegrin and metalloproteinase domain 33, putative
Schistosoma mansoni Smp_160620.1   subfamily M12B unassigned peptidase (M12 family)
Schistosoma mansoni Smp_160620.2   subfamily M12B unassigned peptidase (M12 family)
Schmidtea mediterranea mk4.018201.00  
Schmidtea mediterranea mk4.007325.01  
Schmidtea mediterranea mk4.002281.04  
Schmidtea mediterranea mk4.002281.03  
Schmidtea mediterranea mk4.026266.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ADAM metallopeptidase domain 33 Compounds References
Homo sapiens ADAM metallopeptidase domain 12 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0054 0.5739 0
0.0054 0.5739 0
0.0861 0.5473 1
0.06 0.4336 1
0.0137271 1 1
0.0116 0.3496 0.3496
0.0054 0.5739 0
0.0095 0.5131 0.5131
0.0429 0.2846 1
0.0548 1 1
0.0117 0.5492 0.5492
0.06 0.4336 1
0.0113 0.3124 1
0.0233 0.28 0.3291
0.0198 0.639 1
0.0402 0.6917 0.655
0.0054 0.5739 0
0.0121 0.2573 0.2561
0.0094 0.3686 0.1759
0.012 0.2815 0.2815
0.0094 0.3345 1
0.0054 0.5739 0
0.0137271 1 1
0.0198 1 1
0.0054 0.5739 0
0.0129 1 1
0.0129 1 1
0.0245 0.6007 0.6007
0.0094 0.3345 1
0.0202 0.655 0.655
0.0222 0.4073 0.4069
0.0142562 1 1
0.0054 0.5739 0
0.0142939 1 1
0.0054 0.5739 0
0.0751 0.2802 0.7378
0.0054 0.5739 0
0.0054 0.5739 0
0.0099 1 1
0.06 0.4336 1
0.0054 0.5739 0
0.0226 0.5694 0.5691
0.0226 0.4888 0.643
0.0054 0.5739 0
0.0641 1 1
0.0224 0.2691 0.4178
0.0751 0.2802 0.7378
0.0231 0.5875 0.5875
0.0423 0.2824 1
0.0054 0.5739 0
0.0245 0.2829 0.6867
0.06 0.4336 1
0.0245 0.2855 0.6825
0.0054 0.5739 0

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_160620.2 (Schistosoma mansoni), subfamily M12B unassigned peptidase (M12 family)
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