pI: 7.6554 |
Length (AA): 657 |
MW (Da): 75610 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
40 | 111 | 2e73 (A) | 31 | 103 | 61.00 | 0 | 0.98 | 0.656389 | 1.14 |
43 | 84 | 2row (A) | 23 | 66 | 31.00 | 0.43 | 0.22 | 0.199527 | 1.39 |
108 | 654 | 3pfq (A) | 101 | 667 | 60.00 | 0 | 1 | 1.32627 | 0.5 |
118 | 158 | 2fnf (X) | 128 | 165 | 37.00 | 0.99 | 0.58 | 0.288005 | 1.15 |
321 | 654 | 4ra4 (A) | 332 | 664 | 63.00 | 0 | 1 | 1.21417 | -0.69 |
325 | 606 | 4nw6 (A) | 65 | 354 | 49.00 | 0 | 1 | 1.07982 | -0.88 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129482)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_31105 | Protein kinase c protein 2 |
Candida albicans | CaO19.5901 | protein kinase C similar to S. cerevisiae PKC1 (YBL105C) |
Candida albicans | CaO19.13322 | protein kinase C similar to S. cerevisiae PKC1 (YBL105C) |
Caenorhabditis elegans | CELE_E01H11.1 | Protein PKC-2, isoform D |
Drosophila melanogaster | Dmel_CG6622 | Protein C kinase 53E |
Drosophila melanogaster | Dmel_CG6518 | inactivation no afterpotential C |
Echinococcus granulosus | EgrG_001038500 | RNA directed DNA polymerase |
Echinococcus granulosus | EgrG_000632400 | Protein kinase C brain isozyme |
Echinococcus granulosus | EgrG_000696500 | protein kinase C gamma type |
Echinococcus multilocularis | EmuJ_000696500 | serine threonine protein kinase |
Echinococcus multilocularis | EmuJ_001038500 | telomerase reverse transcriptase subunit |
Echinococcus multilocularis | EmuJ_001039300 | RNA directed DNA polymerase |
Echinococcus multilocularis | EmuJ_000632400 | Protein kinase C, brain isozyme |
Homo sapiens | ENSG00000166501 | protein kinase C, beta |
Homo sapiens | ENSG00000126583 | protein kinase C, gamma |
Homo sapiens | ENSG00000154229 | protein kinase C, alpha |
Loa Loa (eye worm) | LOAG_06588 | AGC/PKC/ALPHA protein kinase |
Loa Loa (eye worm) | LOAG_15630 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10111 | hypothetical protein |
Mus musculus | ENSMUSG00000050965 | protein kinase C, alpha |
Mus musculus | ENSMUSG00000078816 | protein kinase C, gamma |
Mus musculus | ENSMUSG00000052889 | protein kinase C, beta |
Schistosoma japonicum | Sjp_0131180 | Protein kinase C gamma type, putative |
Schistosoma japonicum | Sjp_0317610 | Protein kinase C alpha type, putative |
Schistosoma japonicum | Sjp_0091490 | Protein kinase C alpha type, putative |
Schistosoma japonicum | Sjp_0088340 | IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing |
Schistosoma japonicum | Sjp_0056860 | Calcium-dependent protein kinase C, putative |
Schistosoma mansoni | Smp_176360 | serine/threonine protein kinase |
Schistosoma mansoni | Smp_128480 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.014385.00 | Protein kinase C, brain isozyme |
Schmidtea mediterranea | mk4.005601.01 | Protein kinase C, brain isozyme |
Schmidtea mediterranea | mk4.010109.02 | |
Schmidtea mediterranea | mk4.002813.01 | |
Schmidtea mediterranea | mk4.000718.00 | |
Schmidtea mediterranea | mk4.022647.00 | Protein kinase C, brain isozyme |
Schmidtea mediterranea | mk4.005601.00 | |
Schmidtea mediterranea | mk4.000091.04 | Protein kinase C-like 2 |
Schmidtea mediterranea | mk4.008612.01 | Protein kinase C-like 2 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Candida albicans | protein kinase C similar to S. cerevisiae PKC1 (YBL105C) | Compounds | References |
Homo sapiens | protein kinase C, beta | Compounds | References |
Homo sapiens | protein kinase C, alpha | Compounds | References |
Bos taurus | Protein kinase C alpha | Compounds | References |
Rattus norvegicus | Protein kinase C gamma | Compounds | References |
Mus musculus | protein kinase C, alpha | Compounds | References |
Rattus norvegicus | Protein kinase C alpha | Compounds | References |
Rattus norvegicus | Protein kinase C beta | Compounds | References |
Homo sapiens | protein kinase C, gamma | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Oryctolagus cuniculus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 38.4% | 305 aa | Compounds | References |
Xenopus laevis | Aurora kinase B-A | 361 aa | 33.6% | 298 aa | Compounds | References |
Bos taurus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 39.3% | 305 aa | Compounds | References |
Rattus norvegicus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 39.7% | 305 aa | Compounds | References |